دورية أكاديمية
أعرض في EDS

Serum β-synuclein, neurofilament light chain and glial fibrillary acidic protein as prognostic biomarkers in moderate-to-severe acute ischemic stroke.

التفاصيل البيبلوغرافية
العنوان: Serum β-synuclein, neurofilament light chain and glial fibrillary acidic protein as prognostic biomarkers in moderate-to-severe acute ischemic stroke.
المؤلفون: Barba L; Department of Neurology, Martin-Luther-University of Halle-Wittenberg, Ernst-Grube Strasse 40, 06120, Halle (Saale), Germany., Vollmuth C; Department of Neurology, University of Würzburg, Würzburg, Germany., Abu-Rumeileh S; Department of Neurology, Martin-Luther-University of Halle-Wittenberg, Ernst-Grube Strasse 40, 06120, Halle (Saale), Germany., Halbgebauer S; Department of Neurology, University of Ulm, Ulm, Germany., Oeckl P; Department of Neurology, University of Ulm, Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE E.V.), Ulm, Germany., Steinacker P; Department of Neurology, Martin-Luther-University of Halle-Wittenberg, Ernst-Grube Strasse 40, 06120, Halle (Saale), Germany., Kollikowski AM; Department of Neuroradiology, University of Würzburg, Würzburg, Germany., Schultz C; Department of Neurology, University of Würzburg, Würzburg, Germany., Wolf J; Department of Neurology, University of Würzburg, Würzburg, Germany., Pham M; Department of Neuroradiology, University of Würzburg, Würzburg, Germany., Schuhmann MK; Department of Neurology, University of Würzburg, Würzburg, Germany., Heuschmann PU; Institute for Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany., Haeusler KG; Department of Neurology, University of Würzburg, Würzburg, Germany., Stoll G; Department of Neurology, University of Würzburg, Würzburg, Germany., Neugebauer H; Department of Neurology, University of Würzburg, Würzburg, Germany., Otto M; Department of Neurology, Martin-Luther-University of Halle-Wittenberg, Ernst-Grube Strasse 40, 06120, Halle (Saale), Germany. markus.otto@uk-halle.de.
المصدر: Scientific reports [Sci Rep] 2023 Nov 28; Vol. 13 (1), pp. 20941. Date of Electronic Publication: 2023 Nov 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Ischemic Stroke* , Stroke*/therapy, Adult ; Humans ; beta-Synuclein ; Biomarkers ; Glial Fibrillary Acidic Protein ; Infarction, Middle Cerebral Artery ; Intermediate Filaments ; Neurofilament Proteins ; Prognosis
مستخلص: We aimed to assess the prognostic value of serum β-synuclein (β-syn), neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in patients with moderate-to-severe acute ischemic stroke. We measured β-syn, GFAP and NfL in serum samples collected one day after admission in 30 adult patients with moderate-to-severe ischemic stroke due to middle cerebral artery (MCA) occlusion. We tested the associations between biomarker levels and clinical and radiological scores (National Institute of Health Stroke Scale scores, NIHSS, and Alberta Stroke Program Early CT Score, ASPECTS), as well as measures of functional outcome (modified Rankin Scale, mRS). Serum biomarkers were significantly associated with ASPECTS values (β-syn p = 0.0011, GFAP p = 0.0002) but not with NIHSS scores at admission. Patients who received mechanical thrombectomy and intravenous thrombolysis showed lower β-syn (p = 0.029) und NfL concentrations (p = 0.0024) compared to patients who received only mechanical thrombectomy. According to median biomarker levels, patients with high β-syn, NfL or GFAP levels showed, after therapy, lower clinical improvement (i.e., lower 24-h NIHSS change), higher NIHSS scores during hospitalization and higher mRS scores at 3-month follow-up. Elevated serum concentrations of β-syn (p = 0.016), NfL (p = 0.020) or GFAP (p = 0.010) were significantly associated with 3-month mRS of 3-6 vs. 0-2 even after accounting for age, sex and renal function. In patients with moderate-to-severe acute ischemic stroke, serum β-syn, NfL and GFAP levels associated with clinical and radiological scores at different timepoints and were able to predict short- and middle-term clinical outcomes.
(© 2023. The Author(s).)
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معلومات مُعتمدة: Project No. 413657723 German Research Council (Deutsche Forschungsgemeinschaft, DFG); No. CS22/06 Medical Faculty of Halle University (Clinician Scientist-Programme)
المشرفين على المادة: 0 (beta-Synuclein)
0 (Biomarkers)
0 (Glial Fibrillary Acidic Protein)
0 (Neurofilament Proteins)
0 (GFAP protein, human)
0 (SNCB protein, human)
تواريخ الأحداث: Date Created: 20231128 Date Completed: 20231201 Latest Revision: 20231220
رمز التحديث: 20231220
مُعرف محوري في PubMed: PMC10684607
DOI: 10.1038/s41598-023-47765-7
PMID: 38017278
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-023-47765-7