دورية أكاديمية
أعرض في EDS

MET-receptor targeted fluorescent imaging and spectroscopy to detect multifocal papillary thyroid cancer.

التفاصيل البيبلوغرافية
العنوان: MET-receptor targeted fluorescent imaging and spectroscopy to detect multifocal papillary thyroid cancer.
المؤلفون: Metman MJH; Department of Surgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands., Jonker PKC; Department of Surgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.; Department of Endocrine Surgery and Surgical Oncology, Royal North Shore Hospital, St Leonards, Australia., Sondorp LHJ; Department of Surgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.; Department of Biomedical Sciences of Cell & Systems - Section Molecular Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., van Hemel BM; Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Sywak MS; Department of Endocrine Surgery and Surgical Oncology, Royal North Shore Hospital, St Leonards, Australia., Gill AJ; NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital, St Leonards, Australia.; Sydney Medical School, University of Sydney, Sydney, Australia.; Cancer Diagnosis and Pathology Group Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, Australia., Jansen L; Department of Surgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands., van Diest PJ; Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins, Baltimore, USA., van Ginhoven TM; Department of Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands., Löwik CWGM; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands., Nguyen AH; Department of Pathology, Erasmus MC, Rotterdam, the Netherlands., Robinson DJ; Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands., van Dam GM; Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; AxelaRx/TRACER B.V, Groningen, the Netherlands., Links TP; Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Coppes RP; Department of Biomedical Sciences of Cell & Systems - Section Molecular Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Fehrmann RSN; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Kruijff S; Department of Surgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands. s.kruijff@umcg.nl.; Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. s.kruijff@umcg.nl.
المصدر: European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2024 Jul; Vol. 51 (8), pp. 2384-2394. Date of Electronic Publication: 2023 Nov 29.
نوع المنشور: Journal Article; Clinical Trial, Phase I
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Berlin Country of Publication: Germany NLM ID: 101140988 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1619-7089 (Electronic) Linking ISSN: 16197070 NLM ISO Abbreviation: Eur J Nucl Med Mol Imaging Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin : Springer-Verlag Berlin, 2002-
مواضيع طبية MeSH: Thyroid Cancer, Papillary*/diagnostic imaging , Thyroid Neoplasms*/diagnostic imaging , Thyroid Neoplasms*/pathology , Proto-Oncogene Proteins c-met*/metabolism, Humans ; Male ; Female ; Middle Aged ; Adult ; Optical Imaging/methods ; Aged ; Carcinoma, Papillary/diagnostic imaging
مستخلص: Purpose: Multifocal disease in PTC is associated with an increased recurrence rate. Multifocal disease (MD) is underdiagnosed with the current gold standard of pre-operative ultrasound staging. Here, we evaluate the use of EMI-137 targeted molecular fluorescence-guided imaging (MFGI) and spectroscopy as a tool for the intra-operative detection of uni- and multifocal papillary thyroid cancer (PTC) aiming to improve disease staging and treatment selection.
Methods: A phase-1 study (NCT03470259) with EMI-137 was conducted to evaluate the possibility of detecting PTC using MFGI and quantitative fiber-optic spectroscopy.
Results: Fourteen patients underwent hemi- or total thyroidectomy (TTX) after administration of 0.09 mg/kg (n = 1), 0.13 mg/kg (n = 8), or 0.18 mg/kg (n = 5) EMI-137. Both MFGI and spectroscopy could differentiate PTC from healthy thyroid tissue after administration of EMI-137, which binds selectively to MET in PTC. 0.13 mg/kg was the lowest dosage EMI-137 that allowed for differentiation between PTC and healthy thyroid tissue. The smallest PTC focus detected by MFGI was 1.4 mm. MFGI restaged 80% of patients from unifocal to multifocal PTC compared to ultrasound.
Conclusion: EMI-137-guided MFGI and spectroscopy can be used to detect multifocal PTC. This may improve disease staging and treatment selection between hemi- and total thyroidectomy by better differentiation between unifocal and multifocal disease.
Trial Registration: NCT03470259.
(© 2023. The Author(s).)
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معلومات مُعتمدة: project number 10851 KWF Kankerbestrijding
فهرسة مساهمة: Keywords: Molecular fluorescence–guided imaging; Multifocality; Papillary thyroid cancer; Spectroscopy
سلسلة جزيئية: ClinicalTrials.gov NCT03470259
المشرفين على المادة: EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
تواريخ الأحداث: Date Created: 20231128 Date Completed: 20240614 Latest Revision: 20240726
رمز التحديث: 20240727
مُعرف محوري في PubMed: PMC11178647
DOI: 10.1007/s00259-023-06525-5
PMID: 38017325
قاعدة البيانات: MEDLINE
الوصف
تدمد:1619-7089
DOI:10.1007/s00259-023-06525-5