دورية أكاديمية
Water-soluble Moringa oleifera Seed Lectin Exhibits Monoaminergic Pathway-linked Anti-depressive-like Effects in Mice.
| العنوان: | Water-soluble Moringa oleifera Seed Lectin Exhibits Monoaminergic Pathway-linked Anti-depressive-like Effects in Mice. |
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| المؤلفون: | de Siqueira Patriota LL; Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Brazil., de Lima BRF; Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Brazil., de Oliveira Marinho A; Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Brazil., da Costa JA; Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Brazil., Barroso Coelho LCB; Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Brazil., de Melo Rêgo MJB; Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino (NUPIT), Universidade Federal de Pernambuco, Recife, Brazil., da Rocha Pitta MG; Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino (NUPIT), Universidade Federal de Pernambuco, Recife, Brazil., Paiva PMG; Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Brazil., Pereira MC; Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino (NUPIT), Universidade Federal de Pernambuco, Recife, Brazil.; Departamento de Fisiologia e Farmacologia, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Brazil., Napoleão TH; Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Brazil., da Rosa MM; Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Brazil.; Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino (NUPIT), Universidade Federal de Pernambuco, Recife, Brazil. |
| المصدر: | Protein and peptide letters [Protein Pept Lett] 2023; Vol. 30 (12), pp. 1048-1057. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: Netherlands NLM ID: 9441434 Publication Model: Print Cited Medium: Internet ISSN: 1875-5305 (Electronic) Linking ISSN: 09298665 NLM ISO Abbreviation: Protein Pept Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hilversum, The Netherlands : Bentham Science Publishers Original Publication: Schiphol, The Netherlands : Bentham Science Publishers, c1994- |
| مواضيع طبية MeSH: | Lectins* , Moringa oleifera*, Animals ; Mice ; Water ; Caseins ; Seeds |
| مستخلص: | Objectives: The present study investigated the anti-depressive-like (anti-immobility) effect of a lectin from Moringa oleifera seeds (WSMoL) in mice. Methods: To evaluate an acute effect, the animals were treated with WSMoL (1, 2, and 4 mg/kg, i.p.) 30 min before the tail suspension test (TST). To investigate the involvement of monoaminergic and nitrergic signaling, the mice were pre-treated with selective antagonists. The role of the WSMoL carbohydrate-recognizing domain (CRD) was verified using previous blockage with casein (0.5 mg/mL). The subacute anti-immobility effect was also evaluated by administering WSMoL (1, 2, and 4 mg/kg, i.p.) once a day for 7 d. Finally, an open field test (OFT) was performed to identify possible interferences of WSMoL on animal locomotory behavior. Results: WSMoL reduced the immobility time of mice in the TST at all doses, and combined treatment with fluoxetine (5 mg/kg, i.p.) and WSMoL (1 mg/kg) was also effective. The CRD appeared to be involved in the anti-immobility effect since the solution of WSMoL (4 mg/kg) pre-incubated with casein showed no activity. The lectin effect was prevented by the pre-treatment of mice with ketanserin, yohimbine, and SCH 23390, thereby demonstrating the involvement of monoaminergic pathways. In contrast, pre-treatment with L-NAME, aminoguanidine, and L-arginine did not interfere with lectin action. WSMoL exhibited a subacute effect in the TST, thereby reducing immobility time and increasing agitation time even on the seventh day. OFT data revealed that the anti-immobility effect was not caused by interference with locomotor behavior. Conclusion: WSMoL elicits an anti-depressant-like effect that is dependent on monoaminergic signaling. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| معلومات مُعتمدة: | 407192/2018-2,407192/2018-2 Conselho Nacional de Desenvolvimento Científico e Tecnológico; 001,001 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; 0108-2.08/14,0108-2.08/14 Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco |
| فهرسة مساهمة: | Keywords: Moringa oleifera; anti-immobility effect; lectin; monoaminergic signaling; nitrergic signaling.; tail suspension test |
| المشرفين على المادة: | 0 (Lectins) 059QF0KO0R (Water) 0 (Caseins) |
| تواريخ الأحداث: | Date Created: 20231129 Date Completed: 20240108 Latest Revision: 20240108 |
| رمز التحديث: | 20240108 |
| DOI: | 10.2174/0109298665270366231031052629 |
| PMID: | 38018205 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1875-5305 |
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| DOI: | 10.2174/0109298665270366231031052629 |