دورية أكاديمية
Maternal exercise during pregnancy modulates genotoxicity caused by high fructose consumption in mice offspring.
| العنوان: | Maternal exercise during pregnancy modulates genotoxicity caused by high fructose consumption in mice offspring. |
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| المؤلفون: | Magenis ML; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, SC, Brazil., Damiani AP; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, SC, Brazil., Monteiro IO; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, SC, Brazil., Dagostin LS; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, SC, Brazil., Silva NDS; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, SC, Brazil., Scussel R; Laboratory of Experimental Pathophysiology, Graduate Program of Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, SC, Brazil., Nagashima S; Laboratory of Experimental Pathology, Pontifical Catholic University of Paraná-PUCPR, Paraná, SC, Brazil., Langie SAS; Department of Pharmacology & Toxicology, School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, The Netherlands., Pinho RA; Laboratory of Biochemistry Exercise Health, Pontifical Catholic University of Paraná-PUCPR, Paraná, SC, Brazil., de Andrade VM; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, SC, Brazil. |
| المصدر: | Mutagenesis [Mutagenesis] 2024 Mar 12; Vol. 39 (2), pp. 119-140. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 8707812 Publication Model: Print Cited Medium: Internet ISSN: 1464-3804 (Electronic) Linking ISSN: 02678357 NLM ISO Abbreviation: Mutagenesis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1995- : Swansea, UK : Oxford University Press Original Publication: Oxford ; Washington, DC : Published for the United Kingdom Environmental Mutagen Society by IRL Press, [1986- |
| مواضيع طبية MeSH: | Fructose*/adverse effects , Prenatal Exposure Delayed Effects*/metabolism, Pregnancy ; Mice ; Male ; Female ; Animals ; Humans ; Obesity ; Body Weight ; Adiposity ; Lactation |
| مستخلص: | Pregnancy is a period that is characterized by several metabolic and physiological changes and requires special attention, especially with regard to the relationship between feeding and foetal development. Therefore, the objective of this study was to evaluate whether the practice of voluntary physical exercise (VPE) in combination with chronic consumption of fructose (FRU) from the beginning of life and/or until the gestational period causes genotoxic changes in pregnant females and in their offspring. Seventy Swiss female mice received FRU in the hydration bottle and/or practiced VPE for 8 weeks (prepregnancy/pregnancy). After the lactation period, the offspring groups were separated by sex. It was observed that the consumption of FRU affected the food consumption, serum concentration of FRU, and glycemic profile in the mothers and that the VPE decreases these parameters. In addition, FRU was genotoxic in the mothers' peripheral tissues and VPE had a preventive effect on these parameters. The offspring showed changes in food consumption, serum FRU concentration, and body weight, in addition to an increase in the adiposity index in male offspring in the FRU (FRU) group and a decrease in the FRU + VPE group. FRU leads to hepatic steatosis in the offspring and VPE was able to decrease the area of steatosis. In addition, FRU led to genotoxicity in the offspring and VPE was able to modulate this effect, reducing damages. In conclusion, we observed that all interventions with VPE had nutritional, genetic, and biochemical benefits of the mother and her offspring. (© The Author(s) 2023. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| فهرسة مساهمة: | Keywords: foetal programming; fructose; genotoxicity; mutagenicity; physical exercise |
| المشرفين على المادة: | 30237-26-4 (Fructose) |
| تواريخ الأحداث: | Date Created: 20231129 Date Completed: 20240313 Latest Revision: 20240313 |
| رمز التحديث: | 20240313 |
| DOI: | 10.1093/mutage/gead035 |
| PMID: | 38019677 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1464-3804 |
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| DOI: | 10.1093/mutage/gead035 |