دورية أكاديمية
أعرض في EDS

Modeling of cerebellar transcranial electrical stimulation effects on hand tremor in Parkinson's disease.

التفاصيل البيبلوغرافية
العنوان: Modeling of cerebellar transcranial electrical stimulation effects on hand tremor in Parkinson's disease.
المؤلفون: Rahimi S; Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.; Department of Neuroscience, University of Montreal, Montreal, QC, Canada., Towhidkhah F; Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran., Baghdadi G; Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran., Forogh B; Neuromusculoskeletal Research Center, Iran University of Medical Sciences, Tehran, Iran., Saadat P; Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran., Soleimani G; Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran., Habibi SA; Department of Neurology, Hazrat Rasool Hospital, Iran University of Medical Sciences, Tehran, Iran.
المصدر: Frontiers in aging neuroscience [Front Aging Neurosci] 2023 Nov 13; Vol. 15, pp. 1187157. Date of Electronic Publication: 2023 Nov 13 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101525824 Publication Model: eCollection Cited Medium: Print ISSN: 1663-4365 (Print) Linking ISSN: 16634365 NLM ISO Abbreviation: Front Aging Neurosci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Research Foundation
مستخلص: Introduction: Parkinson's disease (PD) is a neurodegenerative disorder with different motor and neurocognitive symptoms. Tremor is a well-known symptom of this disease. Increasing evidence suggested that the cerebellum may substantially contribute to tremors as a clinical symptom of PD. However, the theoretical foundations behind these observations are not yet fully understood.
Methods: In this study, a computational model is proposed to consider the role of the cerebellum and to show the effectiveness of cerebellar transcranial alternating current stimulation (tACS) on the rest tremor in participants with PD. The proposed model consists of the cortex, cerebellum, spinal circuit-muscular system (SC-MS), and basal ganglia blocks as the most critical parts of the brain, which are involved in generating rest tremors. The cortex, cerebellum, and SC-MS blocks were modeled using Van der Pol oscillators that interacted through synchronization procedures. Basal ganglia are considered as a regulator of the coupling weights defined between oscillators. In order to evaluate the global behavior of the model, we applied tACS on the cerebellum of fifteen PD patients for 15 min at each patient's peak frequency of their rest tremors. A tri-axial accelerometer recorded rest tremors before, during, and after the tACS.
Results and Discussion: The simulation of the model provides a suggestion for the possible role of the cerebellum on rest tremors and how cerebellar tACS can affect these tremors. Results of human experiments also showed that the online and offline effects of cerebellar tACS could lead to the reduction of rest tremors significantly by about %76 and %68, respectively. Our findings suggest that the cerebellar tACS could serve as a reliable, therapeutic technique to suppress the PD tremor.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Rahimi, Towhidkhah, Baghdadi, Forogh, Saadat, Soleimani and Habibi.)
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فهرسة مساهمة: Keywords: cerebellum; computational modeling; oscillators; rest tremor; transcranial alternating electrical stimulation
تواريخ الأحداث: Date Created: 20231129 Latest Revision: 20231201
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10679529
DOI: 10.3389/fnagi.2023.1187157
PMID: 38020756
قاعدة البيانات: MEDLINE
الوصف
تدمد:1663-4365
DOI:10.3389/fnagi.2023.1187157