دورية أكاديمية
Circulation of human respiratory syncytial virus and new ON1 genotype in northern Viet Nam, 2017-2020.
| العنوان: | Circulation of human respiratory syncytial virus and new ON1 genotype in northern Viet Nam, 2017-2020. |
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| المؤلفون: | Trang UTH; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Viet Nam.; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Phuong HVM; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Hoang NH; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Viet Nam.; Institute of Genome Research, Vietnam Academy of Science and Technology, Hanoi, Viet Nam., Son NV; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Thanh LT; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Hang NLK; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Cuong VD; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Huong TTT; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Hien NT; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Anh NP; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Mai LQ; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam. |
| المصدر: | Western Pacific surveillance and response journal : WPSAR [Western Pac Surveill Response J] 2023 Oct 16; Vol. 14 (4), pp. 1-9. Date of Electronic Publication: 2023 Oct 16 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: World Health Organization, Regional Office for the Western Pacific Country of Publication: Philippines NLM ID: 101558993 Publication Model: eCollection Cited Medium: Internet ISSN: 2094-7313 (Electronic) Linking ISSN: 20947321 NLM ISO Abbreviation: Western Pac Surveill Response J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Manila, Philippines : World Health Organization, Regional Office for the Western Pacific, c2010- |
| مواضيع طبية MeSH: | Respiratory Syncytial Virus, Human*/genetics , Respiratory Syncytial Virus Infections*/epidemiology, Child ; Humans ; Infant ; Phylogeny ; Vietnam/epidemiology ; Genotype ; Nucleotides |
| مستخلص: | Objective: Human respiratory syncytial virus (RSV) is a primary cause of paediatric severe acute respiratory infection (SARI) worldwide, especially in developing countries. We investigated the genetic characteristics of RSV in northern Viet Nam to determine the prevalence and distribution of subtypes as well as the diversity and transmission patterns of genotypes. Methods: In two facilities, from January 2017 to December 2020, 1563 clinical specimens were collected from paediatric patients hospitalized with SARI and tested for RSV. Selected positive samples underwent sequencing analysis targeting the second hypervariable region of the G gene using next-generation sequencing. Results: The RSV positivity rate was 28.02% (438/1563 samples), and prevalence was highest in children aged < 1 year (43.84%; 192/438). Subtype RSV-A accounted for 53.42% (234/438) of cases, RSV-B for 45.89% (201/438), and there was coinfection in 0.68% (3/438). Both subtypes cocirculated and peaked during August-September in each year of the study. Phylogenetic analysis showed that RSV-A samples belonged to the ON1 genotype, which has three subgenotypes: ON1.1, ON1.2 and ON1.3. However, we did not find the 72-nucleotide duplication in the second hypervariable region of the G gene, a characteristic of genotype ON1, in any RSV-A samples. RSV-B samples belonged to genotype BA9. Discussion: Our results provide additional molecular characterization of RSV infections in Viet Nam. Specially, our study is the first to report the absence of the 72-nucleotide duplication in the G gene of RSV-A genotype ON1 in Viet Nam, which may help in understanding the genetic evolution of RSV and be useful for vaccine development in the future. Competing Interests: The authors have no conflicts of interest to declare. ((c) 2023 The authors; licensee World Health Organization.) |
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| المشرفين على المادة: | 0 (Nucleotides) |
| تواريخ الأحداث: | Date Created: 20231129 Date Completed: 20231201 Latest Revision: 20231201 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10646430 |
| DOI: | 10.5365/wpsar.2023.14.4.990 |
| PMID: | 38021214 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2094-7313 |
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| DOI: | 10.5365/wpsar.2023.14.4.990 |