دورية أكاديمية
أعرض في EDS

Zucker Diabetic-Sprague Dawley Rats Have Impaired Peri-Implant Bone Formation, Matrix Composition, and Implant Fixation Strength.

التفاصيل البيبلوغرافية
العنوان: Zucker Diabetic-Sprague Dawley Rats Have Impaired Peri-Implant Bone Formation, Matrix Composition, and Implant Fixation Strength.
المؤلفون: Anderson KD; Department of Anatomy and Cell Biology Rush University Medical Center Chicago IL USA., Beckmann C; Department of Orthopedic Surgery Rush University Medical Center Chicago IL USA., Heermant S; Department of Orthopedic Surgery Rush University Medical Center Chicago IL USA., Ko FC; Department of Anatomy and Cell Biology Rush University Medical Center Chicago IL USA.; Department of Orthopedic Surgery Rush University Medical Center Chicago IL USA., Dulion B; Department of Anatomy and Cell Biology Rush University Medical Center Chicago IL USA., Tarhoni I; Department of Anatomy and Cell Biology Rush University Medical Center Chicago IL USA., Borgia JA; Department of Anatomy and Cell Biology Rush University Medical Center Chicago IL USA., Virdi AS; Department of Anatomy and Cell Biology Rush University Medical Center Chicago IL USA.; Department of Orthopedic Surgery Rush University Medical Center Chicago IL USA., Wimmer MA; Department of Orthopedic Surgery Rush University Medical Center Chicago IL USA., Sumner DR; Department of Anatomy and Cell Biology Rush University Medical Center Chicago IL USA.; Department of Orthopedic Surgery Rush University Medical Center Chicago IL USA., Ross RD; Department of Anatomy and Cell Biology Rush University Medical Center Chicago IL USA.; Department of Orthopedic Surgery Rush University Medical Center Chicago IL USA.; Department of Microbial Pathogens and Immunity Rush University Medical Center Chicago IL USA.
المصدر: JBMR plus [JBMR Plus] 2023 Oct 11; Vol. 7 (11), pp. e10819. Date of Electronic Publication: 2023 Oct 11 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 101707013 Publication Model: eCollection Cited Medium: Internet ISSN: 2473-4039 (Electronic) Linking ISSN: 24734039 NLM ISO Abbreviation: JBMR Plus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2024- : Oxford : Oxford University Press
Original Publication: [Chichester, West Sussex, UK] : John Wiley & Sons, [2017]-
مستخلص: An increasing number of patients with type 2 diabetes (T2DM) will require total joint replacement (TJR) in the next decade. T2DM patients are at increased risk for TJR failure, but the mechanisms are not well understood. The current study used the Zucker Diabetic-Sprague Dawley (ZDSD) rat model of T2DM with Sprague Dawley (SPD) controls to investigate the effects of intramedullary implant placement on osseointegration, peri-implant bone structure and matrix composition, and fixation strength at 2 and 10 weeks post-implant placement. Postoperative inflammation was assessed with circulating MCP-1 and IL-10 2 days post-implant placement. In addition to comparing the two groups, stepwise linear regression modeling was performed to determine the relative contribution of glucose, cytokines, bone formation, bone structure, and bone matrix composition on osseointegration and implant fixation strength. ZDSD rats had decreased peri-implant bone formation and reduced trabecular bone volume per total volume compared with SPD controls. The osseointegrated bone matrix of ZDSD rats had decreased mineral-to-matrix and increased crystallinity compared with SPD controls. Osseointegrated bone volume per total volume was not different between the groups, whereas implant fixation was significantly decreased in ZDSD at 2 weeks but not at 10 weeks. A combination of trabecular mineral apposition rate and postoperative MCP-1 levels explained 55.6% of the variance in osseointegration, whereas cortical thickness, osseointegration mineral apposition rate, and matrix compositional parameters explained 69.2% of the variance in implant fixation strength. The results support the growing recognition that both peri-implant structure and matrix composition affect implant fixation and suggest that postoperative inflammation may contribute to poor outcomes after TJR surgeries in T2DM patients. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
(© 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.)
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معلومات مُعتمدة: T32 AR073157 United States AR NIAMS NIH HHS
فهرسة مساهمة: Keywords: ANIMAL MODELS; BIOMECHANICS; BONE MATRIX; DIABETES; IMPLANTS
تواريخ الأحداث: Date Created: 20231129 Latest Revision: 20240130
رمز التحديث: 20240130
مُعرف محوري في PubMed: PMC10652173
DOI: 10.1002/jbm4.10819
PMID: 38025036
قاعدة البيانات: MEDLINE
الوصف
تدمد:2473-4039
DOI:10.1002/jbm4.10819