دورية أكاديمية
Risk Profile of High-grade Cervical Lesions and Cervical Cancer Considering the Combination of Cytology, HPV Genotype, and Age among Women Undergoing Colposcopy.
| العنوان: | Risk Profile of High-grade Cervical Lesions and Cervical Cancer Considering the Combination of Cytology, HPV Genotype, and Age among Women Undergoing Colposcopy. |
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| عنوان ترانسليتريتد: | Perfil de risco de lesões cervicais de alto grau e câncer cervical considerando a combinação de citologia, genótipo do HPV e idade entre mulheres submetidas a colposcopia. |
| المؤلفون: | Possati-Resende JC; Prevention Department, Hopital do Câncer de Barretos, SP, Brazil., Fritsch TZ; Research and Education Institute, Hospital do Câncer de Barretos, Barretos, SP, Brazil., Souza KCB; Research and Education Institute, Hospital do Câncer de Barretos, Barretos, SP, Brazil. |
| المصدر: | Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia [Rev Bras Ginecol Obstet] 2023 Nov; Vol. 45 (11), pp. e689-e698. Date of Electronic Publication: 2023 Nov 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Federação das Sociedades de Ginecologia e Obstetrícia Country of Publication: Brazil NLM ID: 9214757 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1806-9339 (Electronic) Linking ISSN: 01007203 NLM ISO Abbreviation: Rev Bras Ginecol Obstet Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2024- : São Paulo : Federação das Sociedades de Ginecologia e Obstetrícia Original Publication: [São Paulo, Brazil] : Medisa Editora |
| مواضيع طبية MeSH: | Uterine Cervical Neoplasms*/diagnosis , Uterine Cervical Neoplasms*/epidemiology , Uterine Cervical Neoplasms*/pathology , Uterine Cervical Dysplasia*/pathology , Papillomavirus Infections*/epidemiology, Pregnancy ; Female ; Humans ; Aged ; Adolescent ; Adult ; Colposcopy ; Human papillomavirus 16 ; Cross-Sectional Studies ; Retrospective Studies ; Human papillomavirus 18 ; Papillomaviridae/genetics ; Genotype ; Early Detection of Cancer/methods |
| مستخلص: | Objective: The present study aims to establish a risk profile for high-grade cervical lesions and cervical cancer (CIN2 + ) in women undergoing colposcopy at the Hospital do Câncer de Barretos, through the analysis of Human Papillomavirus (HPV) infection, cervical cytology, and patient's age. Methods: Retrospective cross-sectional study based on a computerized database of women aged ≥ 18 years old who underwent colposcopy at the Prevention Department of the Hospital do Câncer de Barretos from 2017 to 2019. Results: A total of 3,411 women were included, 58.0% were positive for high-risk-HPV test, with a higher prevalence of CIN2+ for HPV16 (30.3%) and other HPV (45.0%). Cytological findings that suggest invasive cervical cancer (squamous cells or adenocarcinoma), regardless of the status of HPV test, showed 100% diagnosis of CIN2 + , while atypias that suggest high-grade lesions, HSIL and ASC-H, positive for HPV test, showed in 86 and 55.2%, respectively, diagnosis of CIN2 + . ASC-H cytological results among women aged > 40 years old and negative HPV were mainly associated with benign findings. We observed that ≤ CIN1 has a higher prevalence among older women with negative HPV, while for high-grade lesions there is an increase among young women HPV16- and/or 18-positive. In cancer diagnosis, we observed a predominance of HPV 16/18 regardless of the age group. Conclusion: The highest risks of precursor lesions and cervical cancer were found among women with positive HPV 16/18 tests and severe cytological atypia in population screening tests. In addition, cytological findings of ASC-H HPV negative in women > 40 years old usually represent benign findings in histological investigation. Competing Interests: The authors have no conflict of interests to declare. (Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).) |
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| فهرسة مساهمة: | Local Abstract: [Publisher, Portuguese] Estabelecer um perfil de risco de lesões intraepiteliais de alto grau e câncer do colo do útero (NIC2 + ) em mulheres submetidas a colposcopia considerando-se a infecção pelo papilomavírus humano (HPV), citologia cervical e idade. MéTODOS: Estudo retrospectivo transversal em banco de dados informatizado de mulheres com idade ≥ 18 anos que realizaram colposcopia no departamento de Prevenção de Câncer no Hospital do Câncer de Barretos/SP no período de 2017 a 2019. [Publisher, Portuguese] Foram incluídas 3.411 mulheres, sendo 58,0% positivas para HPV de alto risco, e maior prevalência de NIC2+ para HPV16 (30,3%) e outros HPV (45,0%). Resultados citológicos sugestivos de lesões invasivas (epidermoide ou adenocarcinoma), independente do teste de HPV, apresentaram 100% de diagnóstico NIC2 + , enquanto atipias sugestivas de lesões de alto grau, HSIL e ASC-H, associados a HPV positivo, apresentaram 86 e 55,2%, respectivamente. Resultados citológicos de ASC-H entre mulheres > 40 anos e HPV negativo foram associados principalmente a achados benignos. Observamos que ≤ NIC1 apresenta uma maior prevalência entre mulheres mais velhas com HPV negativo, enquanto para lesões de alto grau, há um aumento entre mulheres mais jovens positivas para HPV16/18. Para diagnóstico de câncer, observamos que há um predomínio de HPV16/18 independente da faixa etária. CONCLUSãO: Foi identificado maior risco de lesões precursoras e câncer entre mulheres com HPV 16/18 positivo e atipias citológicas graves em testes de rastreio populacional. Além disso, resultados citológicos de ASC-H quando associados a HPV negativo com idade > 40 anos habitualmente representam achados benignos em investigação histológica. |
| تواريخ الأحداث: | Date Created: 20231129 Date Completed: 20231201 Latest Revision: 20231202 |
| رمز التحديث: | 20231202 |
| مُعرف محوري في PubMed: | PMC10686761 |
| DOI: | 10.1055/s-0043-1772483 |
| PMID: | 38029771 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1806-9339 |
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| DOI: | 10.1055/s-0043-1772483 |