دورية أكاديمية
Exploring the neuroprotective potential of antimicrobial peptides from Dinoponera quadriceps venom against pentylenetetrazole-induced seizures in vivo.
| العنوان: | Exploring the neuroprotective potential of antimicrobial peptides from Dinoponera quadriceps venom against pentylenetetrazole-induced seizures in vivo. |
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| المؤلفون: | Paes LCF; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Universidade Federal Do Ceará, Fortaleza, 60430372, Ceará, Brazil., Lima DB; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Universidade Federal Do Ceará, Fortaleza, 60430372, Ceará, Brazil. Electronic address: danya.dbl@gmail.com., Silva DMAD; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Universidade Federal Do Ceará, Fortaleza, 60430372, Ceará, Brazil., Valentin JT; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Universidade Federal Do Ceará, Fortaleza, 60430372, Ceará, Brazil., Aquino PEA; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, 60430-275, Ceará, Brazil., García-Jareño AB; Targeted Therapies on Cancer and Inflammation Lab and Peptide Synthesis Platform, Centro de Investigación Príncipe Felipe, Valencia, 46012, Spain., Orzaéz M; Targeted Therapies on Cancer and Inflammation Lab and Peptide Synthesis Platform, Centro de Investigación Príncipe Felipe, Valencia, 46012, Spain., Fonteles MMF; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Universidade Federal Do Ceará, Fortaleza, 60430372, Ceará, Brazil; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, 60430-275, Ceará, Brazil., Martins AMC; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Universidade Federal Do Ceará, Fortaleza, 60430372, Ceará, Brazil; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, 60430-275, Ceará, Brazil. Electronic address: martinsalice@gmail.com. |
| المصدر: | Toxicon : official journal of the International Society on Toxinology [Toxicon] 2024 Jan; Vol. 237, pp. 107538. Date of Electronic Publication: 2023 Nov 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 1307333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3150 (Electronic) Linking ISSN: 00410101 NLM ISO Abbreviation: Toxicon Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford ; New York : Pergamon Press, c1962- |
| مواضيع طبية MeSH: | Ants* , Epilepsy*, Humans ; Mice ; Animals ; Male ; Antimicrobial Peptides ; Pentylenetetrazole/toxicity ; Venoms/toxicity ; Seizures/chemically induced ; Seizures/drug therapy ; Seizures/prevention & control ; Anticonvulsants/pharmacology ; Anticonvulsants/therapeutic use ; Peptides/chemistry |
| مستخلص: | Epilepsy affects around 50 million people worldwide and 30% of patients have difficulty controlling the disease. The search for substances that can fill the existing gaps in the treatment of epilepsy is of great importance. Arthropod venoms are promising sources for this purpose due to the presence of small peptides that modulate the activity of ion channels and neuron receptors. The aim of this study was to investigate dinoponeratoxins from the Dinoponera quadriceps ant venom (M-PONTX-Dq3a, M-PONTX-Dq3b and M-PONTX-Dq3c) as potential anticonvulsants. We evaluated them in a seizure model induced by pentylenetetrazole (PTZ) in male swiss mice. Interestingly, intraperitoneal treatment with each peptide increased the time until the first seizure and the percentage of survival, with M-PONTX-Dq3b showing the best results. M-PONTX-Dq3a was discarded due to the appearance of some signs of toxicity with the increase in malondialdehyde (MDA) levels in the striatum. Both, M-PONTX-Dq3b and M-PONTX-Dq3c decreased iNOS and TNF-α in the hippocampus. Notably, M-PONTX-Dq3c treatment decreased the levels of MDA and nitrite in the cortex and hippocampus. Our results indicate that, M-PONTX-Dq3b and M-PONTX-Dq3c have anticonvulsant activity and exhibit anti-inflammatory effects in epilepsy, offering new perspectives for biopharmaceutical development. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Arthropod venom; Dinoponera quadriceps; Epilepsy; Pentylenetetrazole; Peptides; Seizure |
| المشرفين على المادة: | 0 (Antimicrobial Peptides) WM5Z385K7T (Pentylenetetrazole) 0 (Venoms) 0 (Anticonvulsants) 0 (Peptides) |
| تواريخ الأحداث: | Date Created: 20231129 Date Completed: 20231225 Latest Revision: 20231225 |
| رمز التحديث: | 20231225 |
| DOI: | 10.1016/j.toxicon.2023.107538 |
| PMID: | 38030096 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-3150 |
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| DOI: | 10.1016/j.toxicon.2023.107538 |