دورية أكاديمية
أعرض في EDS

Association of Postural Blood Pressure Response With Disease Severity in Primary Open Angle Glaucoma.

التفاصيل البيبلوغرافية
العنوان: Association of Postural Blood Pressure Response With Disease Severity in Primary Open Angle Glaucoma.
المؤلفون: Ameen Ismail A; Department of Ophthalmology, Fayoum University, Al Fayoum, Egypt., Sadek SH, Kamal MA, Hatata RM
المصدر: Journal of glaucoma [J Glaucoma] 2024 Apr 01; Vol. 33 (4), pp. 225-239. Date of Electronic Publication: 2023 Nov 28.
نوع المنشور: Observational Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 9300903 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-481X (Electronic) Linking ISSN: 10570829 NLM ISO Abbreviation: J Glaucoma Subsets: MEDLINE
أسماء مطبوعة: Publication: <2015- > : Philadelphia, PA : Wolters Kluwer Health, Inc.
Original Publication: New York, N.Y. : Raven Press, c1992-
مواضيع طبية MeSH: Glaucoma, Open-Angle*/drug therapy , Glaucoma*/complications , Optic Nerve Diseases*/complications, Humans ; Intraocular Pressure ; Blood Pressure/physiology ; Visual Fields ; Patient Acuity ; Tomography, Optical Coherence
مستخلص: Prcis: Patients with primary open angle glaucoma (POAG) demonstrated exaggerated postural blood pressure dip in recumbency that was positively correlated with the severity of glaucomatous optic neuropathy (GON). Postural dip testing can be used clinically as a marker of systemic vascular dysregulation in GON risk assessment.
Objective: To investigate whether patients with POAG demonstrated abnormal postural blood pressure response to recumbency and whether such abnormal postural response correlated with GON severity.
Patients and Methods: This is a prospective observational study where 47 patients with POAG underwent intraocular pressure and systemic arterial blood pressure, systolic blood pressure (SBP) and diastolic blood pressure (DBP), measurement in seated and after 20-minute recumbency positions. Mean arterial blood pressure (MABP) was calculated for seated and recumbent positions. The percentage difference between seated and recumbent SBP, DBP, and MABP was calculated according to which participants were divided into 3 groups, that is, nondippers, normal dippers, and exaggerated dippers with percentage dips of <10%, ≥10%≤20%, >20%, respectively. Participants underwent optical coherence tomography of optic nerve head to measure retinal nerve fiber layer thickness (RNFLT) which was used as a structural biomarker of GON.
Results: RNFLT was lower in exaggerated dippers than in nondippers and normal dippers. There was a negative correlation between postural dip and average RNFLT. Linear regression showed that postural dip was associated with lower RNFLT independent of age and intraocular pressure. The χ 2 independence test demonstrated a strong relation among corresponding dip groups for SBP, DBP, and MABP. However, it showed no significant relation between hypertension and postural dip. Fisher exact test showed no relation between antihypertensive medication and postural dip.
Conclusions: Patients with POAG demonstrated abnormal postural blood pressure response comprising exaggerated recumbent dip which was positively correlated with disease severity. Postural dip assessment may serve as a simple clinic-based test of systemic vascular dysregulation as part of GON risk evaluation.
Competing Interests: Disclosure: The authors declare no conflict of interest.
(Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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تواريخ الأحداث: Date Created: 20231130 Date Completed: 20240321 Latest Revision: 20240321
رمز التحديث: 20240321
DOI: 10.1097/IJG.0000000000002342
PMID: 38031288
قاعدة البيانات: MEDLINE
الوصف
تدمد:1536-481X
DOI:10.1097/IJG.0000000000002342