Divergent molecular networks program functionally distinct CD8 + skin-resident memory T cells.

التفاصيل البيبلوغرافية
العنوان:	Divergent molecular networks program functionally distinct CD8 ⁺ skin-resident memory T cells.
المؤلفون:	Park SL; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Christo SN; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Wells AC; Metaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, USA., Gandolfo LC; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.; School of Mathematics and Statistics, The University of Melbourne, Melbourne, VIC, Australia.; Walter and Eliza Hall Institute for Medical Research, Parkville, VIC, Australia., Zaid A; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Alexandre YO; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Burn TN; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Schröder J; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Collins N; Metaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, USA., Han SJ; Metaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, USA., Guillaume SM; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Evrard M; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Castellucci C; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Davies B; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Osman M; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Obers A; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., McDonald KM; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Wang H; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Mueller SN; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Kannourakis G; Institute of Innovation, Science and Sustainability, Federation University Australia, Ballarat, VIC, Australia.; Fiona Elsey Cancer Research Institute, Ballarat, VIC, Australia., Berzins SP; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.; Institute of Innovation, Science and Sustainability, Federation University Australia, Ballarat, VIC, Australia.; Fiona Elsey Cancer Research Institute, Ballarat, VIC, Australia., Mielke LA; Olivia Newton-John Cancer Research Institute, La Trobe University School of Cancer Medicine, Heidelberg, VIC, Australia., Carbone FR; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Kallies A; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Speed TP; School of Mathematics and Statistics, The University of Melbourne, Melbourne, VIC, Australia.; Walter and Eliza Hall Institute for Medical Research, Parkville, VIC, Australia., Belkaid Y; Metaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, USA.; NIAID Microbiome Program, NIAID, National Institutes of Health, Bethesda, MD, USA., Mackay LK; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
المصدر:	Science (New York, N.Y.) [Science] 2023 Dec; Vol. 382 (6674), pp. 1073-1079. Date of Electronic Publication: 2023 Nov 30.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
أسماء مطبوعة:	Publication: : Washington, DC : American Association for the Advancement of Science Original Publication: New York, N.Y. : [s.n.] 1880-
مواضيع طبية MeSH:	CD8-Positive T-Lymphocytes/immunology , Immunologic Memory , Memory T Cells/immunology , Skin/immunology, Humans ; Th17 Cells/immunology ; Inducible T-Cell Co-Stimulator Ligand/metabolism ; Proto-Oncogene Proteins c-maf/metabolism ; Interleukin-7/metabolism
مستخلص:	Skin-resident CD8 ⁺ T cells include distinct interferon-γ-producing [tissue-resident memory T type 1 (T RM 1)] and interleukin-17 (IL-17)-producing (T RM 17) subsets that differentially contribute to immune responses. However, whether these populations use common mechanisms to establish tissue residence is unknown. In this work, we show that T RM 1 and T RM 17 cells navigate divergent trajectories to acquire tissue residency in the skin. T RM 1 cells depend on a T-bet-Hobit-IL-15 axis, whereas T RM 17 cells develop independently of these factors. Instead, c-Maf commands a tissue-resident program in T RM 17 cells parallel to that induced by Hobit in T RM 1 cells, with an ICOS-c-Maf-IL-7 axis pivotal to T RM 17 cell commitment. Accordingly, by targeting this pathway, skin T RM 17 cells can be ablated without compromising their T RM 1 counterparts. Thus, skin-resident T cells rely on distinct molecular circuitries, which can be exploited to strategically modulate local immunity.
المشرفين على المادة:	0 (ICOS protein, human) 0 (Inducible T-Cell Co-Stimulator Ligand) 0 (MAF protein, human) 0 (Proto-Oncogene Proteins c-maf) 0 (IL7 protein, human) 0 (Interleukin-7)
تواريخ الأحداث:	Date Created: 20231130 Date Completed: 20231219 Latest Revision: 20231219
رمز التحديث:	20231220
DOI:	10.1126/science.adi8885
PMID:	38033053
قاعدة البيانات:	MEDLINE

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تدمد:	1095-9203
DOI:	10.1126/science.adi8885