دورية أكاديمية
Outcomes of ABO-Incompatible Living Donor Kidney Transplantation Compared to Waiting or Deceased Donor Kidney Transplantation.
| العنوان: | Outcomes of ABO-Incompatible Living Donor Kidney Transplantation Compared to Waiting or Deceased Donor Kidney Transplantation. |
|---|---|
| المؤلفون: | Koo TY; Department of Internal Medicine, Korea University Anam Hospital, Seoul, Republic of Korea., Lee J; Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.; The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Republic of Korea., Lee Y; Department of Internal Medicine, Hanyang University Guri Hospital, Gyeonggi-do, Republic of Korea., Kim HW; Division of Nephrology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Republic of Korea., Kim BS; Division of Nephrology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Republic of Korea., Huh KH; Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.; The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Republic of Korea., Yang J; Division of Nephrology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Republic of Korea. |
| المصدر: | American journal of nephrology [Am J Nephrol] 2024; Vol. 55 (2), pp. 235-244. Date of Electronic Publication: 2023 Nov 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 8109361 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1421-9670 (Electronic) Linking ISSN: 02508095 NLM ISO Abbreviation: Am J Nephrol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel ; New York : Karger, [1981- |
| مواضيع طبية MeSH: | Kidney Transplantation*, Humans ; Living Donors ; Blood Group Incompatibility ; Graft Rejection/epidemiology ; Kidney ; ABO Blood-Group System ; Graft Survival |
| مستخلص: | Introduction: ABO-incompatible (ABOi) living donor kidney transplantation (LDKT) is considered only for patients who do not have an ABO-compatible (ABOc) LD. Therefore, a clinically practical question is whether to proceed with ABOi LDKT or remain on dialysis while waiting for ABOc deceased donor kidney transplantation (DDKT). However, this issue has not been addressed in Asian countries, where ABOi LDKT programs are more active than DDKT programs. Methods: A total of 426 patients underwent ABOi-LDKT between 2010 and 2020 at Seoul National University Hospital and Severance Hospital, Korea. We compared outcomes between the ABOi-LDKT and the propensity-matched control groups (waiting-list-only group, n = 1,278; waiting-list-or-ABOc-DDKT group, n = 1,278). Results: The ABOi-LDKT group showed a significantly better patient survival rate than the waiting-list-only group (p = 0.001) and the waiting-list-or-ABOc-DDKT group (p = 0.048). When the ABOi-LDKT group was categorized into a high-titer group (peak anti-ABO titer ≥1:128) and a low-titer group (peak anti-ABO titer ≤1:64), the low-titer group showed better patient survival rates than those of the waiting-list-or-ABOc-DDKT group (p = 0.046) or the waiting-list-only group (p = 0.004). In contrast, the high-titer ABOi-LDKT group showed no significant benefit in patient survival compared to the waiting-list-or-ABOc-DDKT group. Death-censored graft survival in the ABOi-LDKT group was not significantly different from that in the ABOc-DDKT group (p = 0.563). Conclusion: The ABOi-LDKT group has better outcomes than the waiting-list-or-ABOc-DDKT group in a country with a long waiting time. (© 2023 S. Karger AG, Basel.) |
| فهرسة مساهمة: | Keywords: ABO-incompatible transplantation; Anti-ABO antibody titer; Deceased donor; Kidney transplantation |
| المشرفين على المادة: | 0 (ABO Blood-Group System) |
| تواريخ الأحداث: | Date Created: 20231130 Date Completed: 20240404 Latest Revision: 20240404 |
| رمز التحديث: | 20240404 |
| DOI: | 10.1159/000535583 |
| PMID: | 38035562 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1421-9670 |
|---|---|
| DOI: | 10.1159/000535583 |