دورية أكاديمية
Association of the Complement System with Subclinical Atherosclerosis in Psoriasis: Findings from an Observational Cohort Study.
| العنوان: | Association of the Complement System with Subclinical Atherosclerosis in Psoriasis: Findings from an Observational Cohort Study. |
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| المؤلفون: | Mourino-Alvarez L; Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, SESCAM, Toledo, Spain; Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, IDISCAM, Toledo, Spain., Perales-Sanchez I; Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, SESCAM, Toledo, Spain; Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, IDISCAM, Toledo, Spain., Berna-Rico E; Department of Dermatology, Hospital Universitario Ramon y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain., Abbad-Jaime de Aragon C; Department of Dermatology, Hospital Universitario Ramon y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain., Corbacho-Alonso N; Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, SESCAM, Toledo, Spain; Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, IDISCAM, Toledo, Spain., Sastre-Oliva T; Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, SESCAM, Toledo, Spain; Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, IDISCAM, Toledo, Spain., Juarez-Alia C; Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, SESCAM, Toledo, Spain; Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, IDISCAM, Toledo, Spain., Ballester-Martinez A; Department of Dermatology, Hospital Universitario Ramon y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain., Castellanos-Gonzalez M; Department of Dermatology, Hospital del Sureste, Madrid, Spain., Llamas-Velasco M; Department of Dermatology, Hospital Universitario de la Princesa, Madrid, Spain., Jaen P; Department of Dermatology, Hospital Universitario Ramon y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain., Solis J; Department of Cardiology, Hospital Universitario Doce de Octubre, Madrid, Spain; Atria Clinic, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain., Fernandez-Friera L; Atria Clinic, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain; HM Hospitales-Centro Integral de Enfermedades Cardiovasculares HM-CIEC, Madrid, Spain., Mehta NN; Department of Cardiology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA., Gelfand JM; Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Barderas MG; Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, SESCAM, Toledo, Spain; Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, IDISCAM, Toledo, Spain. Electronic address: megonzalezb@sescam.jccm.es., Gonzalez-Cantero A; Department of Dermatology, Hospital Universitario Ramon y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain; Faculty of Medicine, Universidad Francisco de Vitoria, Madrid, Spain. Electronic address: alvarogc261893@hotmail.com. |
| المصدر: | The Journal of investigative dermatology [J Invest Dermatol] 2024 May; Vol. 144 (5), pp. 1075-1087.e2. Date of Electronic Publication: 2023 Nov 29. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1747 (Electronic) Linking ISSN: 0022202X NLM ISO Abbreviation: J Invest Dermatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : New York : Elsevier Original Publication: Baltimore, Williams & Wilkins. |
| مواضيع طبية MeSH: | Psoriasis*/immunology , Psoriasis*/complications , Psoriasis*/blood , Atherosclerosis*/immunology, Humans ; Male ; Female ; Middle Aged ; Adult ; Proteomics/methods ; Complement System Proteins/metabolism ; Cohort Studies ; Complement Activation ; Computational Biology ; Aged ; Biomarkers/blood |
| مستخلص: | Psoriasis is a chronic and inflammatory disease that affects the skin and joints and is associated with multiple comorbidities and cardiovascular risk factors. Consequently, patients with psoriasis have an increased risk of cardiovascular diseases such as atherosclerosis, a chronic pathology that shares common inflammatory and immune-response mechanisms with psoriasis, including vascular inflammation and complement activation. To better understand the relationship between atherosclerosis and psoriasis, a proteomics study followed by a bioinformatics analysis was carried out, with a subsequent validation step using ELISA and western blotting. When the plasma from patients with psoriasis alone was compared with that from patients with psoriasis and atherosclerosis, 31 proteins of interest related to the complement system and oxygen transport were identified. After the validation phase, 11 proteins appeared to define the presence of subclinical atherosclerosis in patients with psoriasis, indicating the importance of complement cascades in the development of atherosclerotic plaques in individuals with psoriasis. These results are a step forward in understanding the pathological pathways implicated in the cardiovascular risk associated with this population, which may represent an interesting starting point for developing predictive tools that improve the follow-up of these patients and design more effective therapies. (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cardiovascular diseases; Inflammation; Mass spectrometry; Proteomics; Vascular biology |
| المشرفين على المادة: | 9007-36-7 (Complement System Proteins) 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20231130 Date Completed: 20240423 Latest Revision: 20240508 |
| رمز التحديث: | 20240508 |
| DOI: | 10.1016/j.jid.2023.10.031 |
| PMID: | 38036288 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1523-1747 |
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| DOI: | 10.1016/j.jid.2023.10.031 |