دورية أكاديمية
Optic Disc and Retinal Architecture Changes in Patients with Spinocerebellar Ataxia Type 2.
| العنوان: | Optic Disc and Retinal Architecture Changes in Patients with Spinocerebellar Ataxia Type 2. |
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| المؤلفون: | Rezende Filho FM; Division of General Neurology and Ataxia Unit, Department of Neurology, Universidade Federal de São Paulo, Sao Paulo, Brazil., Jurkute N; Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom.; Institute of Ophthalmology, University College London, London, United Kingdom.; The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, United Kingdom., de Andrade JBC; Division of General Neurology and Ataxia Unit, Department of Neurology, Universidade Federal de São Paulo, Sao Paulo, Brazil., Marianelli BF; Department of Ophthalmology, Universidade Federal de São Paulo, Sao Paulo, Brazil., de Lima FD; Department of Neurology, School of Medical Sciences-University of Campinas (UNICAMP), São Paulo, Brazil., França MC Jr; Department of Neurology, School of Medical Sciences-University of Campinas (UNICAMP), São Paulo, Brazil., Sallum JMF; Department of Ophthalmology, Universidade Federal de São Paulo, Sao Paulo, Brazil., Yu-Wai-Man P; Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom.; Institute of Ophthalmology, University College London, London, United Kingdom.; Department of Clinical Neurosciences, Cambridge Centre for Brain Repair and MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, United Kingdom.; Cambridge Eye Unit, Addenbrooke's Hospital, Cambridge University Hospitals, Cambridge, United Kingdom., Barsottini OGP; Division of General Neurology and Ataxia Unit, Department of Neurology, Universidade Federal de São Paulo, Sao Paulo, Brazil., Pedroso JL; Division of General Neurology and Ataxia Unit, Department of Neurology, Universidade Federal de São Paulo, Sao Paulo, Brazil. |
| المصدر: | Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2024 Jan; Vol. 39 (1), pp. 203-209. Date of Electronic Publication: 2023 Nov 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8610688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8257 (Electronic) Linking ISSN: 08853185 NLM ISO Abbreviation: Mov Disord Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2001->: New York, NY : Wiley-Liss Original Publication: [New York, N.Y.] : Raven Press, [c1986- |
| مواضيع طبية MeSH: | Optic Disk*/pathology , Macula Lutea*/pathology, Humans ; Retinal Ganglion Cells/pathology ; Retina/diagnostic imaging ; Retina/pathology ; Tomography, Optical Coherence/methods |
| مستخلص: | Background: ATXN2 is the causative gene of spinocerebellar ataxia type 2 (SCA2) and has been implicated in glaucoma pathogenesis. Therefore, studying ocular changes in SCA2 could uncover clinically relevant changes. Objective: The aim was to investigate optic disc and retinal architecture in SCA2. Methods: We evaluated 14 patients with SCA2 and 26 controls who underwent intraocular pressure measurement, fundoscopy, and macular and peripapillary spectral domain optical coherence tomography (SD-OCT). We compared SD-OCT measurements in SCA2 and controls, and the frequency of glaucomatous changes among SCA2, controls, and 76 patients with other SCAs (types 1, 3, 6, and 7). Results: The macula, peripapillary retinal nerve fiber and inner plexiform layers were thinner in SCA2 than in controls. Increased cup-to-disc ratio was more frequent in SCA2 than in controls and other SCAs. Conclusions: Ocular changes are part of SCA2 phenotype. Future studies should further investigate retinal and optic nerve architecture in this disorder. (© 2023 International Parkinson and Movement Disorder Society.) |
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| فهرسة مساهمة: | Keywords: ataxia; biomarkers; optical coherence tomography; retina; spinocerebellar ataxia type 2 |
| تواريخ الأحداث: | Date Created: 20231201 Date Completed: 20240201 Latest Revision: 20240201 |
| رمز التحديث: | 20240201 |
| DOI: | 10.1002/mds.29675 |
| PMID: | 38037516 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1531-8257 |
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| DOI: | 10.1002/mds.29675 |