دورية أكاديمية
أعرض في EDS

Cognitive, Functional, and Quality of Life Outcomes 6 Months After Mechanical Ventilation for Bronchiolitis: A Secondary Analysis of Data From the Randomized Evaluation of Sedation Titration for Respiratory Failure Trial ( RESTORE ).

التفاصيل البيبلوغرافية
العنوان: Cognitive, Functional, and Quality of Life Outcomes 6 Months After Mechanical Ventilation for Bronchiolitis: A Secondary Analysis of Data From the Randomized Evaluation of Sedation Titration for Respiratory Failure Trial ( RESTORE ).
المؤلفون: Fischer M; School of Medicine, Case Western Reserve University, Cleveland, OH., Ngendahimana DK; Department of Pediatrics, Rainbow Babies and Children's Hospital, Cleveland, OH., Watson RS; Department of Pediatrics, University of Washington, Seattle, WA., Schwarz AJ; Department of Pediatrics, Critical Care Division, CHOC Children's Hospital, Orange, CA., Shein SL; School of Medicine, Case Western Reserve University, Cleveland, OH.; Department of Pediatrics, Rainbow Babies and Children's Hospital, Cleveland, OH.; Division of Pediatric Critical Care Medicine, Rainbow Babies and Children's Hospital, Cleveland, OH.
المصدر: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies [Pediatr Crit Care Med] 2024 Mar 01; Vol. 25 (3), pp. e129-e139. Date of Electronic Publication: 2023 Dec 01.
نوع المنشور: Randomized Controlled Trial; Multicenter Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 100954653 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-7535 (Print) Linking ISSN: 15297535 NLM ISO Abbreviation: Pediatr Crit Care Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Baltimore, MD : Lippincott Williams & Wilkins, c2000-
مواضيع طبية MeSH: Respiratory Insufficiency*/therapy , Respiratory Insufficiency*/complications , Bronchiolitis*/therapy , Bronchiolitis*/complications, Infant ; Child ; Humans ; Child, Preschool ; Respiration, Artificial ; Quality of Life ; Aftercare ; Patient Discharge ; Intensive Care Units, Pediatric ; Cognition
مستخلص: Objectives: To describe rates and associated risk factors for functional decline 6 months after critical bronchiolitis in a large, multicenter dataset.
Design: Nonprespecified secondary analysis of existing 6-month follow-up data of patients in the Randomized Evaluation of Sedation Titration for Respiratory Failure trial ( RESTORE , NCT00814099).
Setting: Patients recruited to RESTORE in any of 31 PICUs in the United States, 2009-2013.
Patients: Mechanically ventilated PICU patients under 2 years at admission with a primary diagnosis of bronchiolitis.
Interventions: There were no interventions in this secondary analysis; in the RESTORE trial, PICUs were randomized to protocolized sedation versus usual care.
Measurements and Main Results: "Functional decline," defined as worsened Pediatric Overall Performance Category and/or Pediatric Cerebral Performance Category (PCPC) scores at 6 months post-PICU discharge as compared with preillness baseline. Quality of life was assessed using Infant Toddler Quality of Life Questionnaire (ITQOL; children < 2 yr old at follow-up) or Pediatric Quality of Life Inventory (PedsQL) at 6 months post-PICU discharge. In a cohort of 232 bronchiolitis patients, 28 (12%) had functional decline 6 months postdischarge, which was associated with unfavorable quality of life in several ITQOL and PedsQL domains. Among 209 patients with normal baseline functional status, 19 (9%) had functional decline. In a multivariable model including all subjects, decline was associated with greater odds of worse baseline PCPC score and longer PICU length of stay (LOS). In patients with normal baseline status, decline was also associated with greater odds of longer PICU LOS.
Conclusions: In a random sampling of RESTORE subjects, 12% of bronchiolitis patients had functional decline at 6 months. Given the high volume of mechanically ventilated patients with bronchiolitis, this observation suggests many young children may be at risk of new morbidities after PICU admission, including functional and/or cognitive morbidity and reduced quality of life.
Competing Interests: Dr. Watson’s institution received funding from the National Institutes of Health (NIH); he received support for article research from the NIH. Dr. Shein received funding from Ceribell and Hill Ward Henderson. The remaining authors have disclosed that they do not have any potential conflicts of interest.
(Copyright © 2023 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.)
References: Pediatr Crit Care Med. 2014 Sep;15(7):640-8. (PMID: 25072478)
Crit Care Med. 2000 Apr;28(4):1173-9. (PMID: 10809301)
Pediatr Crit Care Med. 2021 Dec 1;22(12):1013-1025. (PMID: 34261946)
Pediatr Crit Care Med. 2002 Jan;3(1):1-5. (PMID: 12793913)
Transl Pediatr. 2021 Oct;10(10):2858-2874. (PMID: 34765507)
Chest. 2021 Aug;160(2):529-537. (PMID: 33727033)
Pediatrics. 2006 Nov;118(5):2101-8. (PMID: 17079584)
Med Care. 2001 Aug;39(8):800-12. (PMID: 11468499)
Crit Care Explor. 2019 Aug 01;1(8):e0026. (PMID: 32166268)
Pediatr Crit Care Med. 2021 Jan 1;22(1):27-39. (PMID: 33027242)
Pediatr Crit Care Med. 2006 Mar;7(2):107-14. (PMID: 16446601)
Crit Care. 2020 Jun 16;24(1):347. (PMID: 32546247)
Pediatr Crit Care Med. 2018 Feb;19(2):145-154. (PMID: 29394221)
J Pediatr. 1992 Jul;121(1):68-74. (PMID: 1625096)
Qual Life Res. 2007 Apr;16(3):445-60. (PMID: 17111231)
Pediatrics. 2019 Dec;144(6):. (PMID: 31699829)
Eur J Pediatr. 2019 Feb;178(2):155-160. (PMID: 30368599)
J Pediatr Intensive Care. 2020 Sep 18;10(4):282-288. (PMID: 34745702)
JAMA. 2022 Mar 1;327(9):836-845. (PMID: 35230393)
Proc Natl Acad Sci U S A. 2013 May 28;110(22):9112-7. (PMID: 23650398)
Lancet Child Adolesc Health. 2021 Oct;5(10):739-750. (PMID: 34370979)
Am J Respir Crit Care Med. 2018 Jun 1;197(11):1457-1467. (PMID: 29313710)
JAMA Pediatr. 2014 Jul;168(7):671-6. (PMID: 24862461)
Pediatr Crit Care Med. 2010 Sep;11(5):549-55. (PMID: 20124947)
JAMA. 2015 Jan 27;313(4):379-89. (PMID: 25602358)
Health Qual Life Outcomes. 2007 Jan 03;5:2. (PMID: 17201923)
Pediatr Crit Care Med. 2017 Dec;18(12):1106-1113. (PMID: 28930814)
Respir Care. 2017 Jun;62(6):718-731. (PMID: 28546374)
Crit Care Med. 2012 Apr;40(4):1309-16. (PMID: 22202709)
Pediatr Crit Care Med. 2009 Jan;10(1):41-4. (PMID: 19057434)
Pediatr Crit Care Med. 2014 Mar;15(3):189-96. (PMID: 24366510)
Intensive Care Med. 2008 Jun;34(6):1076-82. (PMID: 18357437)
Eur J Pediatr. 2023 Jan;182(1):403-409. (PMID: 36374303)
JAMA Netw Open. 2022 Mar 1;5(3):e224584. (PMID: 35357460)
Ambul Pediatr. 2003 Nov-Dec;3(6):329-41. (PMID: 14616041)
Children (Basel). 2021 Mar 24;8(4):. (PMID: 33805106)
J Community Health. 2014 Aug;39(4):753-9. (PMID: 24488647)
معلومات مُعتمدة: U01 HL086622 United States HL NHLBI NIH HHS
سلسلة جزيئية: ClinicalTrials.gov NCT00814099
تواريخ الأحداث: Date Created: 20231201 Date Completed: 20240308 Latest Revision: 20240314
رمز التحديث: 20240314
مُعرف محوري في PubMed: PMC10932893
DOI: 10.1097/PCC.0000000000003405
PMID: 38038620
قاعدة البيانات: MEDLINE
الوصف
تدمد:1529-7535
DOI:10.1097/PCC.0000000000003405