دورية أكاديمية
Differences in Absorption and Metabolism between Structured 1,3-Oleate-2-palmitate Glycerol and 1-Oleate-2-palmitate-3-linoleate Glycerol on C57BL/6J Mice.
| العنوان: | Differences in Absorption and Metabolism between Structured 1,3-Oleate-2-palmitate Glycerol and 1-Oleate-2-palmitate-3-linoleate Glycerol on C57BL/6J Mice. |
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| المؤلفون: | Wei T; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, Jiangxi 330047, China., Tan D; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, Jiangxi 330047, China., Zhong S; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, Jiangxi 330047, China., Zhang H; Wilmar (Shanghai) Biotechnology Research & Development Center Co. Ltd., Shanghai 200137, China., Deng Z; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, Jiangxi 330047, China., Li J; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, Jiangxi 330047, China. |
| المصدر: | Journal of agricultural and food chemistry [J Agric Food Chem] 2023 Dec 13; Vol. 71 (49), pp. 19610-19621. Date of Electronic Publication: 2023 Dec 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, American Chemical Society. |
| مواضيع طبية MeSH: | Oleic Acid*/metabolism , Linoleic Acid*/metabolism, Humans ; Mice ; Animals ; Palmitates ; Glycerol ; Cholesterol, LDL ; Mice, Inbred C57BL ; Triglycerides/metabolism ; Linoleic Acids |
| مستخلص: | This study investigated differences in absorption and metabolism between 1,3-oleate-2-palmitate glycerol (OPO) and 1-oleate-2-palmitate-3-linoleate glycerol (OPL) using C57BL/6J mice. OPL was associated with higher postprandial plasma total triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-C) concentrations, and the ratio of LDL-C to high-density lipoprotein cholesterol (HDL-C) compared to those of OPO ( p > 0.05). OPO significantly increased postprandial oleic acid (OA) concentrations compared to OPL over the entire monitoring period ( p < 0.05), while OPL significantly elevated linoleic acid (LA) levels compared to OPO ( p < 0.05). After 1 month of feeding, the mice in both OPO and OPL groups showed lower final weight, weight gain, and liver TG, LDL-C, and LDL/HDL concentrations compared to the control (soybean oil) group. Lipidomics results showed that OPO increased the biosynthesis of very long-chain fatty acids and decreased the abundance of AcCa (16:1), AcCa (18:2), AcCa (18:1), AcCa (16:0), CarE (16:0), and CarE (16:1) relative to OPL. These lipid metabolites were positively correlated with liver TG, LDL-C, and LDL/HDL levels and negatively related to peroxisome proliferator-activated receptors α (PPARα) and acyl-CoA oxidase (ACOX1) expression. This study showed differences in physiologic functions between OPO and OPL and provided support for the future application of OPL in infant formula. |
| فهرسة مساهمة: | Keywords: 1,3-oleate-2-palmitate glycerol; 1-oleate-2-palmitate-3-linoleate glycerol; chemical synthesis of OPO; lipid metabolism; lipidomics |
| المشرفين على المادة: | 2UMI9U37CP (Oleic Acid) 9KJL21T0QJ (Linoleic Acid) 0 (Palmitates) PDC6A3C0OX (Glycerol) 0 (Cholesterol, LDL) 0 (Triglycerides) 0 (Linoleic Acids) |
| تواريخ الأحداث: | Date Created: 20231201 Date Completed: 20231216 Latest Revision: 20231216 |
| رمز التحديث: | 20231217 |
| DOI: | 10.1021/acs.jafc.3c07234 |
| PMID: | 38038963 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-5118 |
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| DOI: | 10.1021/acs.jafc.3c07234 |