دورية أكاديمية
Melt crystallization and thermal degradation profile of the antichagasic drug nifurtimox.
| العنوان: | Melt crystallization and thermal degradation profile of the antichagasic drug nifurtimox. |
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| المؤلفون: | Gross IP; Laboratory of Food, Drug, and Cosmetics (LTMAC), School of Health Sciences, University of Brasilia, 70.910-900 Brasília, DF, Brazil. Electronic address: gross.idejan@gmail.com., Lima AL; Laboratory of Food, Drug, and Cosmetics (LTMAC), School of Health Sciences, University of Brasilia, 70.910-900 Brasília, DF, Brazil., Bedogni GR; Pharmaceutical Technical Area, Department of Pharmacy, Faculty of Biochemical and Pharmaceutical Sciences, National University of Rosario, Rosario, Argentina; National Council for Scientific and Technical Research, Godoy Cruz, Argentina., Sa-Barreto L; Laboratory of Food, Drug, and Cosmetics (LTMAC), School of Health Sciences, University of Brasilia, 70.910-900 Brasília, DF, Brazil., Gratieri T; Laboratory of Food, Drug, and Cosmetics (LTMAC), School of Health Sciences, University of Brasilia, 70.910-900 Brasília, DF, Brazil., Gelfuso GM; Laboratory of Food, Drug, and Cosmetics (LTMAC), School of Health Sciences, University of Brasilia, 70.910-900 Brasília, DF, Brazil., Salomon CJ; Pharmaceutical Technical Area, Department of Pharmacy, Faculty of Biochemical and Pharmaceutical Sciences, National University of Rosario, Rosario, Argentina; National Council for Scientific and Technical Research, Godoy Cruz, Argentina., Cunha-Filho M; Laboratory of Food, Drug, and Cosmetics (LTMAC), School of Health Sciences, University of Brasilia, 70.910-900 Brasília, DF, Brazil. Electronic address: marciliofarm@hotmail.com. |
| المصدر: | Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2024 Feb 15; Vol. 239, pp. 115878. Date of Electronic Publication: 2023 Nov 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2006->: London : Elsevier Science Original Publication: Oxford ; New York : Pergamon Press, c1983- |
| مواضيع طبية MeSH: | Nifurtimox*/metabolism , Nifurtimox*/therapeutic use , Nitrofurans*, Crystallization ; Nitrogen Dioxide ; Pharmaceutical Preparations |
| مستخلص: | Despite nifurtimox (NFX) being a traditional drug for treating Chagas disease, some of its physicochemical properties are still unknown, especially its thermal behavior, which brings important outcomes regarding stability and compatibility. In this work, a comprehensive study of NFX's thermal properties was conducted to assist incremental innovations that can improve the efficacy of this drug in novel pharmaceutical products. For this purpose, thermal analyses associated with spectroscopy and spectrometry techniques were used. DSC analyses revealed that the melt crystallization of the NFX led to its amorphous form with the possible formation of a minor fraction of a different crystalline phase. Coats-Redfern method using TGA results indicated the activation energy of NFX non-isothermal degradation as 348.8 ± 8.2 kJ mol -1 , which coincides with the C-NO Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Amorphous state; Nifurtimox; Thermal degradation |
| المشرفين على المادة: | M84I3K7C2O (Nifurtimox) S7G510RUBH (Nitrogen Dioxide) 0 (Nitrofurans) 0 (Pharmaceutical Preparations) |
| تواريخ الأحداث: | Date Created: 20231201 Date Completed: 20240105 Latest Revision: 20240105 |
| رمز التحديث: | 20240105 |
| DOI: | 10.1016/j.jpba.2023.115878 |
| PMID: | 38039869 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-264X |
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| DOI: | 10.1016/j.jpba.2023.115878 |