دورية أكاديمية
أعرض في EDS

Prognosis of spontaneous bacterial peritonitis in patients with hepatocellular carcinoma.

التفاصيل البيبلوغرافية
العنوان: Prognosis of spontaneous bacterial peritonitis in patients with hepatocellular carcinoma.
المؤلفون: Abdel-Samiee M; Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt., Awad SM; Clinical Microbiology and Immunology and Molecular Microbiology in Liver and GIT Department, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt., Mohamed AA; Benha Fever Hospital, Benha, Egypt., Abdelsameea E; Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt. Electronic address: dreman555@liver.menofia.edu.eg., Taha HA; Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt.
المصدر: The American journal of the medical sciences [Am J Med Sci] 2024 Mar; Vol. 367 (3), pp. 171-180. Date of Electronic Publication: 2023 Dec 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0370506 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-2990 (Electronic) Linking ISSN: 00029629 NLM ISO Abbreviation: Am J Med Sci Subsets: MEDLINE
أسماء مطبوعة: Publication: 2016- : New York : Elsevier
Original Publication: Philadelphia : J. B. Lippincott
مواضيع طبية MeSH: Carcinoma, Hepatocellular*/complications , Liver Neoplasms*/complications , Bacterial Infections*/epidemiology , Peritonitis*/complications , Peritonitis*/microbiology, Humans ; Male ; Female ; Adult ; Middle Aged ; Aged ; Prognosis ; Liver Cirrhosis/complications ; Liver Cirrhosis/microbiology ; Ascites/complications
مستخلص: Background: Hepatocellular carcinoma (HCC) is the fourth leading cause of death from cancer worldwide. Spontaneous bacterial peritonitis (SBP) is associated with poor prognosis. This study aimed to evaluate risk factors, differences in clinical characteristics and prognosis of SBP in patients with HCC in comparison with non-HCC patients.
Methods: This study was conducted on patients with cirrhosis who were admitted to hospital with SBP. The patients were divided into two groups: SBP group with HCC (n = 150) and SBP group without HCC (n = 250).
Results: Men and women accounted for 72% and 28% (n = 108 and 42, respectively) of the population in SBP group with HCC with mean age 55.8 ± 13.1 years. They accounted for 68.4% and 31.6% (n = 171 and 79, respectively) in the SBP group without HCC with mean age 56.8 ± 10.5 years. In-hospital mortality was 25.3% in the SBP group with HCC and 18.8% in SBP group without HCC. Gastrointestinal bleeding was the most common cause of death in both groups. No significant difference was observed in patient outcomes between the two studied groups. The deceased patients had significantly higher levels of leukocytes and neutrophils in ascitic fluid as well as a higher frequency of positive culture results than in patients who survived (p < 0.001). However, there was no significant difference in protein level in ascitic fluid or causative organism between patients who survived and those who died (p = 0.63 and 0.19, respectively).
Conclusions: Prognosis of SBP in patients with HCC seemed similar to that in patients without HCC.
Competing Interests: Declaration of Competing Interest The authors declare that there is no conflict of interest regarding the publication of this paper.
(Copyright © 2023 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Bacterial; Hepatocellular carcinoma; Peritonitis
تواريخ الأحداث: Date Created: 20231202 Date Completed: 20240209 Latest Revision: 20240812
رمز التحديث: 20240813
DOI: 10.1016/j.amjms.2023.11.022
PMID: 38042406
قاعدة البيانات: MEDLINE
الوصف
تدمد:1538-2990
DOI:10.1016/j.amjms.2023.11.022