دورية أكاديمية
The influence of pharmacological mineralocorticoid and glucocorticoid receptor blockade on the cortisol response to psychological stress.
| العنوان: | The influence of pharmacological mineralocorticoid and glucocorticoid receptor blockade on the cortisol response to psychological stress. |
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| المؤلفون: | Deuter CE; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Klinik für Psychiatrie und Psychotherapie, Campus Benjamin Franklin, Berlin, Germany. Electronic address: christian.deuter@charite.de., Kaczmarczyk M; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Klinik für Psychiatrie und Psychotherapie, Campus Benjamin Franklin, Berlin, Germany., Hellmann-Regen J; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Klinik für Psychiatrie und Psychotherapie, Campus Benjamin Franklin, Berlin, Germany; DZPG (German Center for Mental Health), Germany., Kuehl LK; Medical School Berlin, Germany., Wingenfeld K; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Klinik für Psychiatrie und Psychotherapie, Campus Benjamin Franklin, Berlin, Germany; DZPG (German Center for Mental Health), Germany., Otte C; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Klinik für Psychiatrie und Psychotherapie, Campus Benjamin Franklin, Berlin, Germany; DZPG (German Center for Mental Health), Germany. |
| المصدر: | Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2024 Feb 08; Vol. 129, pp. 110905. Date of Electronic Publication: 2023 Dec 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 8211617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4216 (Electronic) Linking ISSN: 02785846 NLM ISO Abbreviation: Prog Neuropsychopharmacol Biol Psychiatry Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford ; New York : Pergamon Press, c1982- |
| مواضيع طبية MeSH: | Spironolactone*/pharmacology , Spironolactone*/metabolism , Mifepristone*/pharmacology , Mifepristone*/metabolism, Male ; Humans ; Hydrocortisone/metabolism ; Mineralocorticoids/metabolism ; Mineralocorticoids/pharmacology ; Receptors, Glucocorticoid/metabolism ; Mineralocorticoid Receptor Antagonists/pharmacology ; Mineralocorticoid Receptor Antagonists/metabolism ; Hypothalamo-Hypophyseal System/metabolism ; Receptors, Mineralocorticoid/metabolism ; Stress, Psychological/drug therapy |
| مستخلص: | The glucocorticoid cortisol is the end product of the hypothalamic-pituitary-adrenal (HPA) axis and crucial for the stress response in humans. Cortisol regulates numerous biological functions by binding to two different types of receptors: the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR). Both receptors are found in the brain where they are crucially involved in various mental functions and in feedback inhibition of cortisol release. The precise role of both receptors in the human stress response is not completely understood. In this study, we examined the effects of pharmacological blockade of the MR or the GR on stress-induced cortisol release in a sample of 318 healthy young men (M = 25.42, SD = 5.01). Participants received the MR antagonist spironolactone (300 mg), the GR antagonist mifepristone (600 mg), or a placebo and were subjected 90 min later to a social-evaluative stressor (Trier Social Stress Test) or a non-stressful control condition. We found significantly higher stress-induced cortisol release in the spironolactone group, whereas participants after mifepristone administration did not differ from the control groups. These results suggest that MR blockade results in attenuated fast negative feedback processes and emphasize the important role of the MR during the early phase of the stress response. Competing Interests: Declaration of Competing Interest No conflicts of interest. (Copyright © 2023. Published by Elsevier Inc.) |
| فهرسة مساهمة: | Keywords: Cortisol; Glucocorticoid receptor; HPA axis; Mifepristone; Mineralocorticoid receptor; Spironolactone; Stress; Trier social stress test |
| المشرفين على المادة: | 27O7W4T232 (Spironolactone) 320T6RNW1F (Mifepristone) WI4X0X7BPJ (Hydrocortisone) 0 (Mineralocorticoids) 0 (Receptors, Glucocorticoid) 0 (Mineralocorticoid Receptor Antagonists) 0 (Receptors, Mineralocorticoid) |
| تواريخ الأحداث: | Date Created: 20231203 Date Completed: 20231219 Latest Revision: 20231219 |
| رمز التحديث: | 20231219 |
| DOI: | 10.1016/j.pnpbp.2023.110905 |
| PMID: | 38043634 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-4216 |
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| DOI: | 10.1016/j.pnpbp.2023.110905 |