دورية أكاديمية
أعرض في EDS

Associations between metals and metabolomic profiles related to diabetes among adults in a rural region.

التفاصيل البيبلوغرافية
العنوان: Associations between metals and metabolomic profiles related to diabetes among adults in a rural region.
المؤلفون: Debertin JG; Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA; Mayo Clinic Alix School of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. Electronic address: juliadebertin@gmail.com., Holzhausen EA; Department of Integrative Physiology, University of Colorado, Boulder, CO, USA., Walker DI; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA., Pacheco BP; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA., James KA; Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA., Alderete TL; Department of Integrative Physiology, University of Colorado, Boulder, CO, USA., Corlin L; Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA; Department of Civil and Environmental Engineering, Tufts University School of Engineering, Medford, MA, USA.
المصدر: Environmental research [Environ Res] 2024 Feb 15; Vol. 243, pp. 117776. Date of Electronic Publication: 2023 Dec 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0147621 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0953 (Electronic) Linking ISSN: 00139351 NLM ISO Abbreviation: Environ Res Subsets: MEDLINE
أسماء مطبوعة: Publication: <2000- > : Amsterdam : Elsevier
Original Publication: New York, Academic Press.
مواضيع طبية MeSH: Diabetes Mellitus, Type 2*/epidemiology , Arsenic*/toxicity , Metals, Heavy*, Adult ; Humans ; Female ; Middle Aged ; Male ; Manganese ; Cadmium ; Tungsten ; Cross-Sectional Studies ; Cobalt
مستخلص: Introduction: Exposure to metals is associated with increased risk of type 2 diabetes (T2D). Potential mechanisms for metals-T2D associations involve biological processes including oxidative stress and disruption of insulin-regulated glucose uptake. In this study, we assessed whether associations between metal exposure and metabolite profiles relate to biological pathways linked to T2D.
Materials and Methods: We used data from 29 adults rural Colorado residents enrolled in the San Luis Valley Diabetes Study. Urinary concentrations of arsenic, cadmium, cobalt, lead, manganese, and tungsten were measured. Metabolic effects were evaluated using untargeted metabolic profiling, which included 61,851 metabolite signals detected in serum. We evaluated cross-sectional associations between metals and metabolites present in at least 50% of samples. Primary analyses adjusted urinary heavy metal concentrations for creatinine. Metabolite outcomes associated with each metal exposure were evaluated using pathway enrichment to investigate potential mechanisms underlying the relationship between metals and T2D.
Results: Participants had a mean age of 58.5 years (standard deviation = 9.2), 48.3% were female, 48.3% identified as Hispanic/Latino, 13.8% were current smokers, and 65.5% had T2D. Of the detected metabolites, 455 were associated with at least one metal, including 42 associated with arsenic, 22 with cadmium, 10 with cobalt, 313 with lead, 66 with manganese, and two with tungsten. The metabolic features were linked to 24 pathways including linoleate metabolism, butanoate metabolism, and arginine and proline metabolism. Several of these pathways have been previously associated with T2D, and our results were similar when including only participants with T2D.
Conclusions: Our results support the hypothesis that metals exposure may be associated with biological processes related to T2D, including amino acid, co-enzyme, and sugar and fatty acid metabolism. Insight into biological pathways could influence interventions to prevent adverse health outcomes due to metal exposure.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
References: BMC Bioinformatics. 2013 Jan 16;14:15. (PMID: 23323971)
J Environ Sci (China). 2023 Feb;124:42-49. (PMID: 36182150)
Public Health. 2012 Oct;126(10):813-20. (PMID: 22922043)
Nutrients. 2022 Oct 13;14(20):. (PMID: 36296955)
J Expo Sci Environ Epidemiol. 2012 Mar-Apr;22(2):182-90. (PMID: 21878987)
Interdiscip Toxicol. 2014 Jun;7(2):60-72. (PMID: 26109881)
Oxid Med Cell Longev. 2018 Apr 5;2018:7580707. (PMID: 29849912)
Environ Res. 2016 May;147:356-64. (PMID: 26945432)
Nat Rev Endocrinol. 2014 Dec;10(12):723-36. (PMID: 25287287)
Environ Int. 2021 Oct;155:106609. (PMID: 33965767)
BMJ Open. 2021 Mar 4;11(3):e039541. (PMID: 33664065)
Rev Environ Health. 2009 Jan-Mar;24(1):15-45. (PMID: 19476290)
Environ Res. 2018 Oct;166:444-451. (PMID: 29940477)
BMJ Open Diabetes Res Care. 2017 Aug 8;5(1):e000427. (PMID: 28878941)
Clin Chem. 2012 Jan;58(1):139-47. (PMID: 22110018)
Int J Environ Res Public Health. 2013 Dec 20;11(1):202-17. (PMID: 24452255)
Chemosphere. 2022 Jul;298:134027. (PMID: 35301998)
Diabet Med. 2013 Apr;30(4):e143-8. (PMID: 23278294)
Nat Med. 2016 Apr;22(4):421-6. (PMID: 26950361)
J Endocrinol. 2012 Oct;215(1):29-42. (PMID: 22718433)
Exp Suppl. 2012;101:133-64. (PMID: 22945569)
Trends Endocrinol Metab. 2017 Aug;28(8):612-625. (PMID: 28571659)
Int J Environ Res Public Health. 2022 Feb 15;19(4):. (PMID: 35206386)
Environ Epidemiol. 2021 Oct 13;5(6):e173. (PMID: 34909553)
Chem Res Toxicol. 2016 Dec 19;29(12):1956-1975. (PMID: 27629808)
Anal Chem. 2020 Jul 7;92(13):8836-8844. (PMID: 32490663)
Am J Epidemiol. 1989 Feb;129(2):295-311. (PMID: 2912042)
Front Pharmacol. 2022 Feb 02;12:837509. (PMID: 35185553)
J Clin Invest. 1953 Apr;32(4):273-82. (PMID: 13052684)
Environ Int. 2018 Nov;120:145-154. (PMID: 30092452)
Int J Epidemiol. 2016 Oct;45(5):1517-1527. (PMID: 27707868)
J Diabetes Metab Disord. 2014 Jan 08;13(1):16. (PMID: 24401367)
Biomed Pharmacother. 2019 Jun;114:108802. (PMID: 30921704)
Bioinformatics. 2009 Aug 1;25(15):1930-6. (PMID: 19414529)
Metabolites. 2019 Dec 21;10(1):. (PMID: 31877765)
J Environ Health Sci. 2019;5(2):90-92. (PMID: 32104722)
Environ Health Perspect. 2016 Dec;124(12):1876-1881. (PMID: 27258818)
Int J Mol Sci. 2018 Oct 23;19(11):. (PMID: 30360467)
Environ Int. 2021 Dec;157:106810. (PMID: 34365318)
Toxicol Sci. 2011 Oct;123(2):305-32. (PMID: 21750349)
Environ Res. 2021 Apr;195:110710. (PMID: 33460634)
J Proteome Res. 2014 Jul 3;13(7):3455-66. (PMID: 24933025)
Environ Int. 2019 May;126:454-467. (PMID: 30844581)
J Clin Invest. 2018 Feb 1;128(2):545-555. (PMID: 29388924)
Diabetes Res Clin Pract. 2008 May;80(2):280-8. (PMID: 18276029)
Cells. 2021 Oct 21;10(11):. (PMID: 34831057)
Chemosphere. 2022 Jan;287(Pt 2):132159. (PMID: 34509013)
J Cell Biochem. 2018 Jan;119(1):157-184. (PMID: 28643849)
Environ Int. 2012 Feb;39(1):150-71. (PMID: 22208756)
Pharmacol Res. 2020 Oct;160:105174. (PMID: 32860943)
Int J Mol Sci. 2020 Aug 30;21(17):. (PMID: 32872570)
JHEP Rep. 2022 Aug 08;4(10):100550. (PMID: 36111068)
Toxicol Appl Pharmacol. 2004 Jun 1;197(2):67-83. (PMID: 15163543)
NDT Plus. 2011 Apr;4(2):83-6. (PMID: 25984118)
معلومات مُعتمدة: K12 HD092535 United States HD NICHD NIH HHS; P50 MD017344 United States MD NIMHD NIH HHS; R00 ES027853 United States ES NIEHS NIH HHS
فهرسة مساهمة: Keywords: Metabolomics; Metals; Pathway enrichment; Rural health; Type 2 diabetes
المشرفين على المادة: 42Z2K6ZL8P (Manganese)
00BH33GNGH (Cadmium)
N712M78A8G (Arsenic)
V9306CXO6G (Tungsten)
0 (Metals, Heavy)
3G0H8C9362 (Cobalt)
تواريخ الأحداث: Date Created: 20231203 Date Completed: 20240206 Latest Revision: 20240218
رمز التحديث: 20240218
مُعرف محوري في PubMed: PMC10872433
DOI: 10.1016/j.envres.2023.117776
PMID: 38043890
قاعدة البيانات: MEDLINE
الوصف
تدمد:1096-0953
DOI:10.1016/j.envres.2023.117776