دورية أكاديمية
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Expression of nonmuscle myosin IIC is regulated by non-canonical binding activity of miRNAs.

التفاصيل البيبلوغرافية
العنوان: Expression of nonmuscle myosin IIC is regulated by non-canonical binding activity of miRNAs.
المؤلفون: Banerjee K; School of Biological Sciences, Indian Association for the Cultivation of Science, Kolkata, India., Saha S; Department of Microbiology, Immunology, and Cancer Biology, Charlottesville, VA, USA., Das S; Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Ghosal S; Bioinformatics and Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA., Ghosh I; School of Biological Sciences, Indian Association for the Cultivation of Science, Kolkata, India., Basu A; Department of General Surgery, Institute of Post Graduate Medical Education and Research, Kolkata, India., Jana SS; School of Biological Sciences, Indian Association for the Cultivation of Science, Kolkata, India.
المصدر: IScience [iScience] 2023 Nov 02; Vol. 26 (12), pp. 108384. Date of Electronic Publication: 2023 Nov 02 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, [2018]-
مستخلص: The expression of mechanoresponsive nonmuscle myosin II (NMII)C is found to be inducible during tumor progression, but its mechanism is yet to be explored. Here, we report a group of microRNAs (mmu-miR-200a-5p, mmu-miR-532-3p, mmu-miR-680, and mmu-miR-1901) can significantly repress the expression of nonmuscle myosin IIC (NMIIC). Interestingly, these microRNAs have both canonical and non-canonical binding sites at 3 / UTR and coding sequence (CDS) of NMIIC's heavy chain (HC) mRNA. Each of the miRNA downregulates NMHC-IIC to a different degree as assessed by dual-luciferase and immunoblot analyses. When we abolish the complementary base pairing at canonical binding site, mmu-miR-532-3p can still bind at non-canonical binding site and form Argonaute2 (AGO2)-miRNA complex to downregulate the expression of NMIIC. Modulating the expression of NMIIC by miR-532-3p in mouse mammary tumor cells, 4T1, increases its tumorigenic potential both in vitro and in vivo . Together, these studies provide the functional role of miRNA's non-canonical binding mediated NMIIC regulation in tumor cells.
Competing Interests: The authors declare no competing or financial interests.
(© 2023.)
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فهرسة مساهمة: Keywords: Biochemistry; Cell biology; Molecular mechanism of gene regulation
تواريخ الأحداث: Date Created: 20231204 Latest Revision: 20231205
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10690570
DOI: 10.1016/j.isci.2023.108384
PMID: 38047082
قاعدة البيانات: MEDLINE
الوصف
تدمد:2589-0042
DOI:10.1016/j.isci.2023.108384