دورية أكاديمية
أعرض في EDS

Innate Allorecognition in Transplantation: Ancient Mechanisms With Modern Impact.

التفاصيل البيبلوغرافية
العنوان: Innate Allorecognition in Transplantation: Ancient Mechanisms With Modern Impact.
المؤلفون: Gui Z; Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA., Al Moussawy M, Sanders SM, Abou-Daya KI
المصدر: Transplantation [Transplantation] 2024 Jul 01; Vol. 108 (7), pp. 1524-1531. Date of Electronic Publication: 2023 Dec 05.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0132144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-6080 (Electronic) Linking ISSN: 00411337 NLM ISO Abbreviation: Transplantation Subsets: MEDLINE
أسماء مطبوعة: Publication: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: Baltimore, Williams & Wilkins.
مواضيع طبية MeSH: Immunity, Innate* , Graft Rejection*/immunology , Graft Rejection*/prevention & control , Organ Transplantation*/history , Immunologic Memory*, Humans ; Animals ; Graft Survival/immunology ; Adaptive Immunity ; Transplantation Immunology ; Transplantation Tolerance
مستخلص: Through the effective targeting of the adaptive immune system, solid organ transplantation became a life-saving therapy for organ failure. However, beyond 1 y of transplantation, there is little improvement in transplant outcomes. The adaptive immune response requires the activation of the innate immune system. There are no modalities for the specific targeting of the innate immune system involvement in transplant rejection. However, the recent discovery of innate allorecognition and innate immune memory presents novel targets in transplantation that will increase our understanding of organ rejection and might aid in improving transplant outcomes. In this review, we look at the latest developments in the study of innate allorecognition and innate immune memory in transplantation.
Competing Interests: The authors declare no conflicts of interest.
(Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.)
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معلومات مُعتمدة: 2020 Stuart K. Patrick Grant for Transplant Innovation Thomas E. Starzl Transplantation Institute
تواريخ الأحداث: Date Created: 20231205 Date Completed: 20240625 Latest Revision: 20240625
رمز التحديث: 20240626
مُعرف محوري في PubMed: PMC11188633
DOI: 10.1097/TP.0000000000004847
PMID: 38049941
قاعدة البيانات: MEDLINE
الوصف
تدمد:1534-6080
DOI:10.1097/TP.0000000000004847