دورية أكاديمية
A Report on a Nationwide Surveillance System for Pediatric Acute Hepatitis of Unknown Etiology in Korea.
| العنوان: | A Report on a Nationwide Surveillance System for Pediatric Acute Hepatitis of Unknown Etiology in Korea. |
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| المؤلفون: | Lee KJ; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea., Ko JS; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea., Park KY; Department of Pediatrics, Gangneung Asan Hospital, College of Medicine, Ulsan University, Gangneung, Korea., Kang KS; Department of Pediatrics, Jeju National University Hospital, Jeju, Korea., Lee K; Department of Pediatrics, Dankook University Hospital, Cheonan, Korea., Hong J; Department of Pediatrics, Kangwon National University School of Medicine, Chuncheon, Korea., Kim SC; Department of Pediatrics, Jeonbuk National University Medical School and Hospital, Jeonju, Korea., Lee Y; Department of Pediatrics, Korea University Medical Center Anam Hospital, Seoul, Korea., Kang B; Department of Pediatrics, School of Medicine, Kyungpook National University, Kyungpook National University Children's Hospital, Daegu, Korea., Kim YB; Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea., Kim HJ; Department of Pediatrics, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, Korea., Eun BW; Department of Pediatrics, Eulji University Eulji General Hospital, Seoul, Korea., Cho HK; Department of Pediatrics, Ewha Womans University Mokdong Hospital, Seoul, Korea., Kim YJ; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., Kim MJ; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., Lee J; Department of Pediatrics, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea., Lee TJ; Department of Pediatrics, CHA University School of Medicine, Pocheon, Korea., Oh SH; Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea., Park S; Department of Pediatrics, Severance Children's Hospital, Severance Pediatric Liver Research Group, Yonsei University College of Medicine, Seoul, Korea., Hwang EH; Department of Pediatrics, Pusan National University Children's Hospital, Pusan National University School of Medicine, Yangsan, Korea., Sohn S; Department of Pediatrics, Pusan National University Children's Hospital, Pusan National University School of Medicine, Yangsan, Korea., Lim JG; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea., Kim Y; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea., Lee YJ; Department of Pediatrics, Pusan National University Children's Hospital, Pusan National University School of Medicine, Yangsan, Korea. moonmissing@gmail.com. |
| المصدر: | Journal of Korean medical science [J Korean Med Sci] 2023 Dec 04; Vol. 38 (47), pp. e401. Date of Electronic Publication: 2023 Dec 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Korean Academy of Medical Science Country of Publication: Korea (South) NLM ID: 8703518 Publication Model: Electronic Cited Medium: Internet ISSN: 1598-6357 (Electronic) Linking ISSN: 10118934 NLM ISO Abbreviation: J Korean Med Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Seoul, Korea : Korean Academy of Medical Science, [1986- |
| مواضيع طبية MeSH: | Hepatitis* , Liver Transplantation*/adverse effects , Liver Failure, Acute*/diagnosis , Liver Failure, Acute*/epidemiology , Liver Failure, Acute*/etiology, Humans ; Child ; Child, Preschool ; Retrospective Studies ; Prognosis ; Acute Disease ; Adenoviridae ; Republic of Korea/epidemiology |
| مستخلص: | Background: Several cases of pediatric acute hepatitis of unknown etiology related to adenoviral infections have been reported in Europe since January 2022. The aim of this study was to compare the incidence, severity, possible etiology, and prognosis of the disease with those in the past in Korea. Methods: The surveillance group collected data between May and November 2022 using a surveillance system. Acute hepatitis of unknown etiology was defined in patients aged < 16 years with a serum transaminase level > 500 IU/L, not due to hepatitis A-E or other underlying causes. For comparison, data from 18 university hospitals were retrospectively collected as a control group between January 2021 and April 2022. Results: We enrolled 270 patients (mean age, 5 years). The most common symptom was fever. However, the incidence was similar between 2021 and 2022. Liver function test results, number of patients with acute liver failure (ALF), liver transplantation (LT), death, and adenovirus detection rates did not differ between the two groups. None of the adenovirus-positive patients in either group experienced ALF, LT, or death. In the surveillance group, adenovirus-associated virus-2 was detected in four patients, one of whom underwent LT. Patients with an unknown etiology showed significantly higher bilirubin levels, a lower platelet count, and a higher LT rate than patients with a possible etiology. Conclusion: The incidence of pediatric acute hepatitis of unknown etiology and adenovirus detection rate have not increased in Korea. Competing Interests: The authors have no potential conflicts of interest to disclose. (© 2023 The Korean Academy of Medical Sciences.) |
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| معلومات مُعتمدة: | 2022-07-011 Korea KDCA Korea Disease Control and Prevention Agency |
| فهرسة مساهمة: | Keywords: Adenovirus; Children; Hepatitis; Unknown Etiology |
| تواريخ الأحداث: | Date Created: 20231205 Date Completed: 20231207 Latest Revision: 20231207 |
| رمز التحديث: | 20240514 |
| مُعرف محوري في PubMed: | PMC10695753 |
| DOI: | 10.3346/jkms.2023.38.e401 |
| PMID: | 38050913 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1598-6357 |
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| DOI: | 10.3346/jkms.2023.38.e401 |