دورية أكاديمية
Biofunctional Inorganic Layered Double Hydroxide Nanohybrid Enhances Immunotherapeutic Effect on Atopic Dermatitis Treatment.
| العنوان: | Biofunctional Inorganic Layered Double Hydroxide Nanohybrid Enhances Immunotherapeutic Effect on Atopic Dermatitis Treatment. |
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| المؤلفون: | Byun MJ; Department of Biomedical Engineering, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea.; Department of Intelligent Precision Healthcare Convergence, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea., Seo HS; Department of Biomedical Engineering, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea.; Department of Intelligent Precision Healthcare Convergence, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea., Lee J; Department of Engineering Chemistry, Chungbuk National University, Cheongju, Chungbuk, 28644, Republic of Korea., Ban K; Department of Engineering Chemistry, Chungbuk National University, Cheongju, Chungbuk, 28644, Republic of Korea., Oh S; Department of Engineering Chemistry, Chungbuk National University, Cheongju, Chungbuk, 28644, Republic of Korea., Lee YY; Department of Biomedical Engineering, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea.; Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea., Lim J; Department of Biomedical Engineering, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea.; Department of Intelligent Precision Healthcare Convergence, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea., Lee NK; Department of Biomedical Engineering, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea.; Department of Intelligent Precision Healthcare Convergence, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea., Wang CJ; Department of Biomedical Engineering, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea.; Department of Intelligent Precision Healthcare Convergence, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea., Kim M; Department of Biomedical Engineering, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea.; Department of Intelligent Precision Healthcare Convergence, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea., Han JH; Department of Intelligent Precision Healthcare Convergence, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea.; Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea., Park J; Department of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School Medicine, University of Hawai'i at Manoa, Honolulu, Hawaii, 96813, USA., Paik T; School of Integrative Engineering, Chung-Ang University, Seoul, 06974, Republic of Korea., Park HH; Department of Bioengineering, Hanyang University, Seoul, 04763, Republic of Korea., Park TE; Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea., Park W; Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea.; Biomaterials Research Center, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea., Kim SN; Research and Development Center, MediArk Inc., Cheongju, Chungbuk, 28644, Republic of Korea.; Department of Industrial Cosmetic Science, College of Bio-Health University System, Chungbuk National University, Cheongju, Chungbuk, 28644, Republic of Korea., Park DH; Department of Engineering Chemistry, Chungbuk National University, Cheongju, Chungbuk, 28644, Republic of Korea.; Department of Industrial Cosmetic Science, College of Bio-Health University System, Chungbuk National University, Cheongju, Chungbuk, 28644, Republic of Korea.; Department of Synchrotron Radiation Science and Technology, College of Bio-Health University System, Chungbuk National University, Cheongju, Chungbuk, 28644, Republic of Korea.; LANG SCIENCE Inc, Cheongju, Chungbuk, 28644, Republic of Korea., Park CG; Department of Biomedical Engineering, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea.; Department of Intelligent Precision Healthcare Convergence, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea.; Biomaterials Research Center, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.; Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea. |
| المصدر: | Small (Weinheim an der Bergstrasse, Germany) [Small] 2024 Apr; Vol. 20 (17), pp. e2304862. Date of Electronic Publication: 2023 Dec 05. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101235338 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1613-6829 (Electronic) Linking ISSN: 16136810 NLM ISO Abbreviation: Small Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Weinheim, Germany : Wiley-VCH, c2005- |
| مواضيع طبية MeSH: | Hydroxides*/chemistry , Dermatitis, Atopic*/drug therapy , Dermatitis, Atopic*/pathology , Indoleacetic Acids*/chemistry , Indoleacetic Acids*/pharmacology, Animals ; Mice ; Macrophages/drug effects ; Macrophages/metabolism ; Immunotherapy/methods ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Reactive Oxygen Species/metabolism |
| مستخلص: | Atopic dermatitis (AD) is a widespread, recurrent, and chronic inflammatory skin condition that imposes a major burden on patients. Conventional treatments, such as corticosteroids, are associated with various side effects, underscoring the need for innovative therapeutic approaches. In this study, the possibility of using indole-3-acetic acid-loaded layered double hydroxides (IAA-LDHs) is evaluated as a novel treatment for AD. IAA is an auxin-class plant hormone with antioxidant and anti-inflammatory effects. Following the synthesis of IAA-LDH nanohybrids, their ability to induce M2-like macrophage polarization in macrophages obtained from mouse bone marrow is assessed. The antioxidant activity of IAA-LDH is quantified by assessing the decrease in intracellular reactive oxygen species levels. The anti-inflammatory and anti-atopic characteristics of IAA-LDH are evaluated in a mouse model of AD by examining the cutaneous tissues, immunological organs, and cells. The findings suggest that IAA-LDH has great therapeutic potential as a candidate for AD treatment based on its in vitro and in vivo modulation of AD immunology, enhancement of macrophage polarization, and antioxidant activity. This inorganic drug delivery technology represents a promising new avenue for the development of safe and effective AD treatments. (© 2023 Wiley‐VCH GmbH.) |
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| معلومات مُعتمدة: | 2023-00208913 Ministry of Science and ICT (MSIT) of the Republic of Korea; 2022R1A4A2000776 Ministry of Science and ICT (MSIT) of the Republic of Korea; 2022R1F1A1065525 Ministry of Science and ICT (MSIT) of the Republic of Korea; KFRM 21A0501L1 Korea government (MSIT and the Ministry of Health & Welfare); 2021RIS-001 Ministry of Education; RS-2023-00266015 Ministry of Health & Welfare, Republic of Korea; 2E32351-23-130 KIST Institutional Program |
| فهرسة مساهمة: | Keywords: atopic dermatitis; immunosuppression; layered double hydroxides; macrophage polarization; nanohybrid |
| المشرفين على المادة: | 0 (Hydroxides) 0 (Indoleacetic Acids) 0 (Antioxidants) 6U1S09C61L (indoleacetic acid) 0 (Reactive Oxygen Species) |
| تواريخ الأحداث: | Date Created: 20231205 Date Completed: 20240425 Latest Revision: 20240425 |
| رمز التحديث: | 20240426 |
| DOI: | 10.1002/smll.202304862 |
| PMID: | 38050931 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1613-6829 |
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| DOI: | 10.1002/smll.202304862 |