دورية أكاديمية
Association Between Adequate Serum 25(OH)D Levels and Atherogenic Dyslipidemia in Young Adults.
العنوان: | Association Between Adequate Serum 25(OH)D Levels and Atherogenic Dyslipidemia in Young Adults. |
---|---|
المؤلفون: | Chen CW; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine.; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch., Han YY; Department of Anesthesiology, National Taiwan University Hospital.; Department of Traumatology, National Taiwan University Hospital., Hwang JS; Institute of Statistical Science, Academia Sinica., Rizzo M; Department of Internal Medicine and Medical Specialties (DIMIS), Universita degli Studi di Palermo UNIPA., Yamashita S; Department of Cardiology, Rinku General Medical Center., Huey-Jen Hsu S; Department of Laboratory Medicine, College of Medicine, National Taiwan University Hospital, National Taiwan University., Su TC; Department of Environmental and Occupational Medicine, National Taiwan University Hospital.; Institute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University.; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital. |
المصدر: | Journal of atherosclerosis and thrombosis [J Atheroscler Thromb] 2024 May 01; Vol. 31 (5), pp. 524-539. Date of Electronic Publication: 2023 Dec 05. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Japan Atherosclerosis Society Country of Publication: Japan NLM ID: 9506298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1880-3873 (Electronic) Linking ISSN: 13403478 NLM ISO Abbreviation: J Atheroscler Thromb Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Tokyo : Japan Atherosclerosis Society |
مواضيع طبية MeSH: | Vitamin D*/*analogs & derivatives, Dyslipidemias*/blood , Vitamin D*/blood , Atherosclerosis*/blood , Atherosclerosis*/etiology , Atherosclerosis*/epidemiology , Biomarkers*/blood, Humans ; Male ; Female ; Young Adult ; Adult ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology ; Risk Factors ; Triglycerides/blood ; Cross-Sectional Studies |
مستخلص: | Aim: This study aimed to investigate the association between vitamin D deficiency and novel biomarkers of atherogenic dyslipidemia among young adults. Method: A total of 976 young adults were recruited between 2011 and 2019. Their serum 25(OH)D levels were measured, and lipid profile markers, including low-density lipoprotein cholesterol (LDL-C), low-density lipoprotein triglyceride (LDL-TG), and small-dense low-density lipoprotein cholesterol (sdLDL-C), were assessed as novel biomarkers of atherogenic dyslipidemia. Multivariable linear regression was used to analyze the association between vitamin D levels and lipid profile markers. Odds ratios were calculated to assess the risk of atherogenic dyslipidemia in individuals with serum 25(OH)D levels below 30 ng/mL compared to those with levels above 30 ng/mL. Structural equation modeling (SEM) was employed to explore potential mediation pathways. Results: The study found a significant association between vitamin D levels and lower levels of LDL-C, LDL-TG, sdLDL-C, non-high-density lipoprotein cholesterol (non-HDL-C), triglycerides, and total cholesterol. Individuals with serum 25(OH)D levels below 30 ng/mL exhibited significantly higher odds ratios for developing atherogenic dyslipidemia in a dose-response pattern compared to those with vitamin D levels above 30 ng/mL. Notably, structural equation modeling (SEM) analysis revealed that vitamin D did not affect atherogenic lipid markers through the mediation of insulin resistance markers or high-sensitivity C-reactive protein. Conclusion: This study provides evidence of an association between vitamin D deficiency and atherogenic dyslipidemia in young adults. It further highlights that individuals with serum 25(OH)D levels below 30 ng/mL are at a significantly higher risk of developing atherogenic dyslipidemia in a dose-response manner compared to those with higher vitamin D levels. These findings underscore the potential role of vitamin D in dyslipidemia management and emphasize the importance of maintaining sufficient vitamin D levels for cardiovascular health in young adults. |
References: | Diabetes. 2016 Jul;65(7):1767-78. (PMID: 27329952) J Am Coll Cardiol. 2008 Dec 9;52(24):1949-56. (PMID: 19055985) Endocr Rev. 2022 Jul 13;43(4):611-653. (PMID: 34676866) J Atheroscler Thromb. 2004;11(4):200-8. (PMID: 15356379) J Am Coll Cardiol. 2018 Jul 10;72(2):156-169. (PMID: 29976289) JAMA. 2005 May 11;293(18):2257-64. (PMID: 15886381) Biomedicines. 2021 Feb 09;9(2):. (PMID: 33572397) Nutr Metab Cardiovasc Dis. 2022 Apr;32(4):957-964. (PMID: 35078678) Int J Epidemiol. 2023 Feb 8;52(1):260-271. (PMID: 35579027) Pediatr Int. 2021 Jun;63(6):664-670. (PMID: 33020997) J Am Coll Cardiol. 2017 Jul 4;70(1):1-25. (PMID: 28527533) Nutrients. 2022 Jan 12;14(2):. (PMID: 35057483) Asia Pac J Clin Nutr. 2020;29(4):839-845. (PMID: 33377379) J Atheroscler Thromb. 2012;19(10):924-31. (PMID: 22785083) Calcif Tissue Int. 2020 Jan;106(1):14-29. (PMID: 31069443) Biomedicines. 2021 Apr 24;9(5):. (PMID: 33923190) Eur J Clin Nutr. 2020 Nov;74(11):1498-1513. (PMID: 31959942) Nutr Res. 2011 Jan;31(1):48-54. (PMID: 21310306) Shanghai Arch Psychiatry. 2013 Dec;25(6):390-4. (PMID: 24991183) Endocr J. 2000 Aug;47(4):383-91. (PMID: 11075718) Diabetes Metab Syndr. 2021 Jul-Aug;15(4):102200. (PMID: 34265491) J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. (PMID: 21646368) J Am Diet Assoc. 2005 Jun;105(6):971-4. (PMID: 15942551) Eur Rev Med Pharmacol Sci. 2017 Mar;21(5):1060-1064. (PMID: 28338187) Am J Physiol Heart Circ Physiol. 2020 Oct 1;319(4):H906-H914. (PMID: 32857616) PLoS One. 2014 Feb 11;9(2):e88547. (PMID: 24523914) Mol Cell Endocrinol. 2011 Dec 5;347(1-2):25-9. (PMID: 21664413) Nutrients. 2020 Feb 22;12(2):. (PMID: 32098418) J Atheroscler Thromb. 2022 Feb 1;29(2):242-251. (PMID: 33518614) Biochem J. 2017 Mar 24;474(8):1321-1332. (PMID: 28341729) Environ Health Prev Med. 2020 Jan 15;25(1):4. (PMID: 31941477) Anal Chem. 2005 May 1;77(9):3001-7. (PMID: 15859623) J Nutr. 2005 Nov;135(11):2739S-48S. (PMID: 16251641) Curr Med Res Opin. 2019 Jun;35(6):1059-1063. (PMID: 30479168) Circulation. 2022 Feb 22;145(8):e153-e639. (PMID: 35078371) Curr Diab Rep. 2018 Oct 17;18(12):127. (PMID: 30328521) Public Health Nutr. 2011 Feb;14(2):340-6. (PMID: 20854716) Int J Endocrinol. 2022 Jul 6;2022:6453882. (PMID: 35859985) Osteoporos Int. 2012 Feb;23(2):675-86. (PMID: 21625888) J Inflamm Res. 2014 May 29;7:69-87. (PMID: 24971027) Public Health Nutr. 2015 Mar;18(4):721-6. (PMID: 24963684) Nutrients. 2022 Aug 26;14(17):. (PMID: 36079784) J Atheroscler Thromb. 2015;22(4):355-62. (PMID: 25346256) Biomed Res Int. 2021 Dec 14;2021:2259711. (PMID: 34950730) |
فهرسة مساهمة: | Keywords: 25-hydroxyvitamin D; Atherogenic dyslipidemia; Cardiovascular diseases; LDL-C; LDL-TG; Vitamin D deficiency; sdLDL-C |
المشرفين على المادة: | 1406-16-2 (Vitamin D) 0 (Biomarkers) A288AR3C9H (25-hydroxyvitamin D) 0 (Triglycerides) |
تواريخ الأحداث: | Date Created: 20231206 Date Completed: 20240501 Latest Revision: 20240511 |
رمز التحديث: | 20240511 |
مُعرف محوري في PubMed: | PMC11079497 |
DOI: | 10.5551/jat.64523 |
PMID: | 38057082 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1880-3873 |
---|---|
DOI: | 10.5551/jat.64523 |