دورية أكاديمية
Association Between Adequate Serum 25(OH)D Levels and Atherogenic Dyslipidemia in Young Adults.
| العنوان: | Association Between Adequate Serum 25(OH)D Levels and Atherogenic Dyslipidemia in Young Adults. |
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| المؤلفون: | Chen CW; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine.; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch., Han YY; Department of Anesthesiology, National Taiwan University Hospital.; Department of Traumatology, National Taiwan University Hospital., Hwang JS; Institute of Statistical Science, Academia Sinica., Rizzo M; Department of Internal Medicine and Medical Specialties (DIMIS), Universita degli Studi di Palermo UNIPA., Yamashita S; Department of Cardiology, Rinku General Medical Center., Huey-Jen Hsu S; Department of Laboratory Medicine, College of Medicine, National Taiwan University Hospital, National Taiwan University., Su TC; Department of Environmental and Occupational Medicine, National Taiwan University Hospital.; Institute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University.; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital. |
| المصدر: | Journal of atherosclerosis and thrombosis [J Atheroscler Thromb] 2024 May 01; Vol. 31 (5), pp. 524-539. Date of Electronic Publication: 2023 Dec 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Japan Atherosclerosis Society Country of Publication: Japan NLM ID: 9506298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1880-3873 (Electronic) Linking ISSN: 13403478 NLM ISO Abbreviation: J Atheroscler Thromb Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Tokyo : Japan Atherosclerosis Society |
| مواضيع طبية MeSH: | Vitamin D*/*analogs & derivatives, Dyslipidemias*/blood , Vitamin D*/blood , Atherosclerosis*/blood , Atherosclerosis*/etiology , Atherosclerosis*/epidemiology , Biomarkers*/blood, Humans ; Male ; Female ; Young Adult ; Adult ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology ; Risk Factors ; Triglycerides/blood ; Cross-Sectional Studies |
| مستخلص: | Aim: This study aimed to investigate the association between vitamin D deficiency and novel biomarkers of atherogenic dyslipidemia among young adults. Method: A total of 976 young adults were recruited between 2011 and 2019. Their serum 25(OH)D levels were measured, and lipid profile markers, including low-density lipoprotein cholesterol (LDL-C), low-density lipoprotein triglyceride (LDL-TG), and small-dense low-density lipoprotein cholesterol (sdLDL-C), were assessed as novel biomarkers of atherogenic dyslipidemia. Multivariable linear regression was used to analyze the association between vitamin D levels and lipid profile markers. Odds ratios were calculated to assess the risk of atherogenic dyslipidemia in individuals with serum 25(OH)D levels below 30 ng/mL compared to those with levels above 30 ng/mL. Structural equation modeling (SEM) was employed to explore potential mediation pathways. Results: The study found a significant association between vitamin D levels and lower levels of LDL-C, LDL-TG, sdLDL-C, non-high-density lipoprotein cholesterol (non-HDL-C), triglycerides, and total cholesterol. Individuals with serum 25(OH)D levels below 30 ng/mL exhibited significantly higher odds ratios for developing atherogenic dyslipidemia in a dose-response pattern compared to those with vitamin D levels above 30 ng/mL. Notably, structural equation modeling (SEM) analysis revealed that vitamin D did not affect atherogenic lipid markers through the mediation of insulin resistance markers or high-sensitivity C-reactive protein. Conclusion: This study provides evidence of an association between vitamin D deficiency and atherogenic dyslipidemia in young adults. It further highlights that individuals with serum 25(OH)D levels below 30 ng/mL are at a significantly higher risk of developing atherogenic dyslipidemia in a dose-response manner compared to those with higher vitamin D levels. These findings underscore the potential role of vitamin D in dyslipidemia management and emphasize the importance of maintaining sufficient vitamin D levels for cardiovascular health in young adults. |
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| فهرسة مساهمة: | Keywords: 25-hydroxyvitamin D; Atherogenic dyslipidemia; Cardiovascular diseases; LDL-C; LDL-TG; Vitamin D deficiency; sdLDL-C |
| المشرفين على المادة: | 1406-16-2 (Vitamin D) 0 (Biomarkers) A288AR3C9H (25-hydroxyvitamin D) 0 (Triglycerides) |
| تواريخ الأحداث: | Date Created: 20231206 Date Completed: 20240501 Latest Revision: 20240511 |
| رمز التحديث: | 20240511 |
| مُعرف محوري في PubMed: | PMC11079497 |
| DOI: | 10.5551/jat.64523 |
| PMID: | 38057082 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1880-3873 |
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| DOI: | 10.5551/jat.64523 |