دورية أكاديمية
أعرض في EDS

Fabrication and characterizations of simvastatin-containing mesoporous bioactive glass and molybdenum disulfide scaffold for bone tissue engineering.

التفاصيل البيبلوغرافية
العنوان: Fabrication and characterizations of simvastatin-containing mesoporous bioactive glass and molybdenum disulfide scaffold for bone tissue engineering.
المؤلفون: Murugan SS; Biomaterials Research Laboratory, Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore, Karnataka 575018, India., Dalavi PA; Biomaterials Research Laboratory, Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore, Karnataka 575018, India., Surya S; Advancement Surgical Skill Enhancement Division, Yenepoya (Deemed to be University), Deralakatte, Mangalore, Karnataka 575018, India., Anil S; Department of Dentistry, Oral Health Institute, Hamad Medical Corporation, College of Dental Medicine, Qatar University, Doha, Qatar., Gupta S; Biomaterials Research Laboratory, Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore, Karnataka 575018, India., Shetty R; Department of Surgical Oncology, Yenepoya Medical College Hospital, Mangalore, Karnataka, India., Venkatesan J; Biomaterials Research Laboratory, Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore, Karnataka 575018, India.
المصدر: APL bioengineering [APL Bioeng] 2023 Dec 04; Vol. 7 (4), pp. 046115. Date of Electronic Publication: 2023 Dec 04 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: AIP Publishing Country of Publication: United States NLM ID: 101726398 Publication Model: eCollection Cited Medium: Internet ISSN: 2473-2877 (Electronic) Linking ISSN: 24732877 NLM ISO Abbreviation: APL Bioeng Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Melville, NY : AIP Publishing, [2017]-
مستخلص: Due to the limitations of the current treatment approaches of allograft and autograft techniques, treating bone disorders is a significant challenge. To address these shortcomings, a novel biomaterial composite is required. This study presents the preparation and fabrication of a novel biomaterial composite scaffold that combines poly (D, L-lactide-co-glycolide) (PLGA), mesoporous bioactive glass (MBG), molybdenum disulfide (MoS 2 ), and simvastatin (Sim) to address the limitations of current bone grafting techniques of autograft and allograft. The fabricated scaffold of PLGA-MBG-MoS 2 -Sim composites was developed using a low-cost hydraulic press and salt leaching method, and scanning electron microscopy (SEM) analysis confirmed the scaffolds have a pore size between 143 and 240  μ m. The protein adsorption for fabricated scaffolds was increased at 24 h. The water adsorption and retention studies showed significant results on the PLGA-MBG-MoS 2 -Sim composite scaffold. The biodegradation studies of the PLGA-MBG-MoS 2 -Sim composite scaffold have shown 54% after 28 days. In vitro , bioactivity evaluation utilizing simulated body fluid studies confirmed the development of bone mineral hydroxyapatite on the scaffolds, which was characterized using x-ray diffraction, Fourier transform infrared, and SEM analysis. Furthermore, the PLGA-MBG-MoS 2 -Sim composite scaffold is biocompatible with C3H10T1/2 cells and expresses more alkaline phosphatase and mineralization activity. Additionally, in vivo research showed that PLGA-MBG-MoS 2 -Sim stimulates a higher rate of bone regeneration. These findings highlight the fabricated PLGA-MBG-MoS 2 -Sim composite scaffold presents a promising solution for the limitations of current bone grafting techniques.
Competing Interests: The authors have no conflicts to disclose.
(© 2023 Author(s).)
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تواريخ الأحداث: Date Created: 20231207 Latest Revision: 20231208
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10697724
DOI: 10.1063/5.0172002
PMID: 38058994
قاعدة البيانات: MEDLINE
الوصف
تدمد:2473-2877
DOI:10.1063/5.0172002