دورية أكاديمية
Effect of dolutegravir-based drug combinations on the level of medication adherence and viral load among adolescents living with HIV in resource-limited setting: a pre-post design.
| العنوان: | Effect of dolutegravir-based drug combinations on the level of medication adherence and viral load among adolescents living with HIV in resource-limited setting: a pre-post design. |
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| المؤلفون: | Ezenwosu IL; Department of Community Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu State, Nigeria., Onu JU; Department of Mental Health, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria., Chukwuma UV; Department of Family Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu State, Nigeria., Onwuka-Kalu C; Department of Hematology and Immunology, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu State, Nigeria., Omotola OF; Department of Pharmacy, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu State, Nigeria., Ezenwosu OU; Department of Paediatrics, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu State, Nigeria., Chukwuka CJ; Department of Internal Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu State, Nigeria. |
| المصدر: | International journal of adolescent medicine and health [Int J Adolesc Med Health] 2023 Dec 08; Vol. 35 (6), pp. 457-465. Date of Electronic Publication: 2023 Dec 08 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Walter de Gruyter Country of Publication: Germany NLM ID: 8506960 Publication Model: eCollection Cited Medium: Internet ISSN: 2191-0278 (Electronic) Linking ISSN: 03340139 NLM ISO Abbreviation: Int J Adolesc Med Health Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2011- : Berlin : Walter de Gruyter Original Publication: London : Freund Pub. House, c1985- |
| مواضيع طبية MeSH: | HIV Infections*/drug therapy , HIV Integrase Inhibitors*/therapeutic use , HIV Integrase Inhibitors*/pharmacology, Male ; Child ; Humans ; Adolescent ; Female ; Viral Load ; Drug Combinations ; Medication Adherence |
| مستخلص: | Objectives: The use of antiretroviral drugs among HIV-infected adolescents has been challenged with poor medication adherence, leading to an unsuppressed viral load and ultimately to drug resistance. Recently, dolutegravir has been approved for use in adolescents with HIV, but the evidence on medication adherence and viral load suppression is limited. The study determined the effect of dolutegravir-based drug regimens on the level of medication adherence and viral load among treatment-experienced adolescents. Methods: A longitudinal pre-post design study was done among adolescents living with HIV at a paediatrics clinic in Nigeria. Assessment of medication adherence and viral load testing was done before and at six months of transitioning to dolutegravir-based regimens. McNemar-chi-square was used to determine the effectiveness of the drug on adherence and viral load suppression. Multivariate logistic regression analysis was performed to determine the predictors of drug adherence and viral suppression. Results: The mean age of the participants was 14.7 years (SD=3.2), and 53.3 % were males. The mean duration of ART use was 10.3 years (SD=3.2). Six months after transitioning to dolutegravir, there was a significant decrease in viral load (Z=-7.947, p<0.001) and an increase in medication adherence score (Z=-7.554, p<0.001), among the treatment-experienced adolescents. Viral suppression was 13 times higher among respondents with good medication adherence as compared to those with poor medication adherence (AOR=13.24, CI=3.25-53.90). Conclusions: Dolutegravir is effective in improving medication adherence and viral suppression among Adolescents living with HIV. Thus, the need to transition eligible adolescents to dolutegravir to sustain better treatment outcomes. (© 2023 Walter de Gruyter GmbH, Berlin/Boston.) |
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| فهرسة مساهمة: | Keywords: adolescents; dolutegravir; drug adherence; viral suppression |
| المشرفين على المادة: | DKO1W9H7M1 (dolutegravir) 0 (HIV Integrase Inhibitors) 0 (Drug Combinations) |
| تواريخ الأحداث: | Date Created: 20231207 Date Completed: 20231225 Latest Revision: 20231225 |
| رمز التحديث: | 20231225 |
| DOI: | 10.1515/ijamh-2023-0082 |
| PMID: | 38059505 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2191-0278 |
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| DOI: | 10.1515/ijamh-2023-0082 |