دورية أكاديمية
أعرض في EDS

Iontophoresis use for increasing drug penetration into root canals and dentinal tubules: A proof-of-concept study.

التفاصيل البيبلوغرافية
العنوان: Iontophoresis use for increasing drug penetration into root canals and dentinal tubules: A proof-of-concept study.
المؤلفون: Miranda TC; Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia, 70910-900, Brasília, DF, Brazil., Oliveira LA; Department of Dentistry, Faculty of Health Sciences, University of Brasilia, 70910-900, Brasília, DF, Brazil., Hilgert LA; Department of Dentistry, Faculty of Health Sciences, University of Brasilia, 70910-900, Brasília, DF, Brazil., Cunha-Filho M; Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia, 70910-900, Brasília, DF, Brazil., Gelfuso GM; Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia, 70910-900, Brasília, DF, Brazil., Gratieri T; Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia, 70910-900, Brasília, DF, Brazil. Electronic address: tgratieri@gmail.com.
المصدر: Journal of dentistry [J Dent] 2024 Feb; Vol. 141, pp. 104797. Date of Electronic Publication: 2023 Dec 05.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 0354422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-176X (Electronic) Linking ISSN: 03005712 NLM ISO Abbreviation: J Dent Subsets: MEDLINE
أسماء مطبوعة: Publication: Kidlington : Elsevier
Original Publication: Bristol, Eng., Wright.
مواضيع طبية MeSH: Iontophoresis* , Dentin*, Animals ; Cattle ; Pharmaceutical Preparations ; Dental Pulp Cavity ; Methylene Blue/pharmacology ; Root Canal Preparation/methods ; Root Canal Irrigants/pharmacology
مستخلص: Introduction: The success of endodontic treatment depends on the significant disinfection of the root canal system, its irregularities, and dentinal tubules. However, achieving complete disinfection remains challenging, with frequent failures and occurrence of secondary infections. Here, we propose using iontophoresis to increase the penetration and distribution of disinfecting agents into root canals, using methylene blue for proof-of-concept.
Methods: The marker was applied in bovine root canals, and the radial distribution of the dye in the dentinal tubules was evaluated by optical microscopy. Iontophoresis was applied at 0.5 and 1.5 mA for 5 and 15 min.
Results: A significant statistical difference (p < 0.05) was observed in the marker penetration between passive and iontophoretic applications. Both current density and application time had an important effect on methylene blue distribution, with a greater efficacy delivery to the apical region achieved after 1.5 mA for 5 min or 0.5 mA for 15 min, showing longer application time can compensate for lower application current.
Conclusion: Iontophoresis increases the penetration and distribution of methylene blue into bovine root canals and dentinal tubules, including its innermost portions.
Clinical Significance: Iontophoresis has shown to be a promising technique for root canal and dentinal tubule disinfection.
Competing Interests: Declaration of Competing Interest The authors declare that they have no competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Dentinal tubules; Endodontics; Iontophoresis; Methylene blue; Root canals
المشرفين على المادة: 0 (Pharmaceutical Preparations)
T42P99266K (Methylene Blue)
0 (Root Canal Irrigants)
تواريخ الأحداث: Date Created: 20231207 Date Completed: 20240126 Latest Revision: 20240606
رمز التحديث: 20240606
DOI: 10.1016/j.jdent.2023.104797
PMID: 38061412
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-176X
DOI:10.1016/j.jdent.2023.104797