التفاصيل البيبلوغرافية
| العنوان: |
[Metabolic Heterogeneity of Tumors]. |
| المؤلفون: |
Shirmanova MV; Privolzhsky Research Medical University, Nizhny Novgorod, 603005 Russia.; Shirmanovam@mail.ru., Sinyushkina SD; Privolzhsky Research Medical University, Nizhny Novgorod, 603005 Russia., Komarova AD; Privolzhsky Research Medical University, Nizhny Novgorod, 603005 Russia.; Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, 603950 Russia. |
| المصدر: |
Molekuliarnaia biologiia [Mol Biol (Mosk)] 2023 Nov-Dec; Vol. 57 (6), pp. 1130-1149. |
| نوع المنشور: |
Review; English Abstract; Journal Article |
| اللغة: |
Russian |
| بيانات الدورية: |
Publisher: Izdatelstvo Nauka Country of Publication: Russia (Federation) NLM ID: 0105454 Publication Model: Print Cited Medium: Print ISSN: 0026-8984 (Print) Linking ISSN: 00268984 NLM ISO Abbreviation: Mol Biol (Mosk) Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Moskva : Izdatelstvo Nauka |
| مواضيع طبية MeSH: |
Neoplasms*/diagnostic imaging , Neoplasms*/metabolism, Humans |
| مستخلص: |
Currently, much attention in oncology is devoted to the issues of tumor heterogeneity, which creates serious problems in the diagnosis and therapy of malignant neoplasms. Intertumoral and intratumoral differences relate to various characteristics and aspects of the vital activity of tumor cells, including cellular metabolism. This review provides general information about the tumor metabolic heterogeneity with a focus on energy metabolism, its causes, mechanisms and research methods. Among the methods, fluorescence lifetime imaging is described in more detail as a new promising method for observing metabolic heterogeneity at the cellular level. The review demonstrates the importance of studying the features of tumor metabolism and identifying intra- and intertumoral metabolic differences. |
| فهرسة مساهمة: |
Keywords: energy metabolism; fluorescence lifetime imaging; glycolysis; metabolic cofactors; oxidative phosphorylation; tumor heterogeneity; tumors |
| تواريخ الأحداث: |
Date Created: 20231208 Date Completed: 20231227 Latest Revision: 20231227 |
| رمز التحديث: |
20231228 |
| DOI: |
10.31857/S0026898423060186, EDN: QIJIYQ |
| PMID: |
38062965 |
| قاعدة البيانات: |
MEDLINE |
