دورية أكاديمية
أعرض في EDS

Histopathologic Characterization of Incidental Lesions Encountered During Mohs Micrographic Surgery With MART-1 Immunohistochemistry.

التفاصيل البيبلوغرافية
العنوان: Histopathologic Characterization of Incidental Lesions Encountered During Mohs Micrographic Surgery With MART-1 Immunohistochemistry.
المؤلفون: Hirotsu KE; Department of Dermatology, Stanford University School of Medicine, Stanford, California., Kibbi N; Department of Dermatology, Stanford University School of Medicine, Stanford, California., Rieger KE; Department of Dermatology, Stanford University School of Medicine, Stanford, California.; Department of Pathology, Stanford University School of Medicine, Stanford, California., Aasi SZ; Department of Dermatology, Stanford University School of Medicine, Stanford, California.
المصدر: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] [Dermatol Surg] 2024 Mar 01; Vol. 50 (3), pp. 234-240. Date of Electronic Publication: 2023 Dec 05.
نوع المنشور: Review; Journal Article
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Health Country of Publication: United States NLM ID: 9504371 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4725 (Electronic) Linking ISSN: 10760512 NLM ISO Abbreviation: Dermatol Surg Subsets: MEDLINE
أسماء مطبوعة: Publication: 2021- : [Philadelphia] : Wolters Kluwer Health
Original Publication: New York, NY : Elsevier Science, c1995-
مواضيع طبية MeSH: Melanoma*/diagnosis , Melanoma*/surgery , Skin Neoplasms*/diagnosis , Skin Neoplasms*/surgery, Humans ; Mohs Surgery ; Immunohistochemistry ; Eosine Yellowish-(YS)
مستخلص: Background: As the use of melanoma antigen recognized by T cells (MART-1) immunohistochemistry (IHC) with Mohs surgery increases for the treatment of melanoma in situ and invasive melanoma, surgeons should be aware of MART-1 staining patterns of incidental lesions often encountered on frozen sections. Lack of this knowledge can lead to unnecessary additional surgery, increased health care costs, and loss of valuable laboratory staff time and resources.
Objective: To characterize the histopathologic features of incidental lesions encountered during Mohs surgery for melanoma. To review key diagnostic and differentiating features on hematoxylin and eosin staining (H&E) and MART-1 IHC of these lesions.
Methods: A comprehensive review of frozen-section histopathology slides from Mohs cases with MART-1 IHC at our institution was conducted from 2021 to 2023.
Results: Incidental benign and malignant lesions were identified and characterized on H&E frozen sections and MART-1 IHC. Although such entities can share MART-1 staining characteristics with melanoma in situ or melanoma, distinguishing characteristics on H&E and lack of histopathologic criteria for melanoma on MART-1 IHC can be used to distinguish these incidental lesions from melanoma.
Conclusion: Staining of frozen sections for Mohs micrographic surgery with H&E and MART-1 IHC together can differentiate common incidental benign and malignant cutaneous lesions from melanoma.
(Copyright © 2023 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.)
References: Valentín-Nogueras SM, Brodland DG, Zitelli JA, González-Sepúlveda L, et al. Mohs micrographic surgery using MART-1 immunostain in the treatment of invasive melanoma and melanoma in situ. Dermatol Surg 2016;42:733–44.
Christensen KN, Hochwalt PC, Hocker TL, Roenigk RK, et al. Comparison of MITF and melan-A immunohistochemistry during Mohs surgery for lentigo maligna-type melanoma in situ and lentigo maligna melanoma. Dermatol Surg 2016;42:167–75.
Muzumdar S, Argraves M, Kristjansson A, Ferenczi K, et al. A quantitative comparison between SOX10 and MART-1 immunostaining to detect melanocytic hyperplasia in chronically sun-damaged skin. J Cutan Pathol 2018;45:263–8.
Hendi A, Brodland DG, Zitelli JA. Melanocytes in long-standing sun-exposed skin: quantitative analysis using the MART-1 immunostain. Arch Dermatol 2006;142:871–6.
Shin TM, Nugent S, Aizman L, Weiner DM, et al. Mohs micrographic surgery with MART-1 immunostaining has durable low local recurrence rates for in situ and invasive melanomas. J Am Acad Dermatol 2021;84:196–8.
Fazio J, Heras A, Stein E, Zitelli J. Melanoma antigen recognized by T cells with blue chromogen improves identification of melanocytes from background melanized keratinocytes on frozen sections. Dermatol Surg 2023;49:709–11.
Elston D, Ferringer T, Ko C, Peckham S, et al. Dermatopathology. 3rd ed. Amsterdam, Netherlands: Elsevier; 2018.
Helm K, Findeis-Hosey J. Immunohistochemistry of pigmented actinic keratoses, actinic keratoses, melanomas in situ and solar lentigines with Melan-A. J Cutan Pathol 2008;35:931–4.
Aasi SZ, Leffell DJ, Lazova RZ. Atlas of Practical Mohs Histopathology. New York, NY: Springer; 2013.
Damsky WE, Bosenberg M. Melanocytic nevi and melanoma: unraveling a complex relationship. Oncogene 2017;36:5771–92.
Donaldson MR, Morrell TJ, Weber LA. Dermal MART-1-positive proliferations encountered on Mohs sections during melanoma treatment. Dermatol Surg 2023;49:201–4.
Morgan MB, Stevens GL, Switlyk S. Benign lichenoid keratosis: a clinical and pathologic reappraisal of 1040 cases. Am J Dermatopathol 2005;27:387–92.
Patterson J. Weedon’s Skin Pathology. Amsterdam, Netherlands: Elsevier; 2021.
Beltraminelli H, Shabrawi-Caelen LE, Kerl H, Cerroni L. Melan-a-positive "pseudomelanocytic nests": a pitfall in the histopathologic and immunohistochemical diagnosis of pigmented lesions on sun-damaged skin. Am J Dermatopathol 2009;31:305–8.
Chan AH, Shulman KJ, Lee BA. Differentiating regressed melanoma from regressed lichenoid keratosis. J Cutan Pathol 2017;44:338–41.
Panse G, McNiff JM. Lichenoid dermatoses with pseudomelanocytic nests vs inflamed melanoma in situ: a comparative study. J Cutan Pathol 2021;48:745–9.
Fix WC, Yun SJ, Groft MacFarlane CM, Jambusaria A, et al. MART-1-labeled melanocyte density and distribution in actinic keratosis and squamous cell cancer in situ: pagetoid melanocytes are a potential source of misdiagnosis as melanoma in situ. J Cutan Pathol 2018;45:734–42.
Brankov N, Prodanovic EM, Hurley MY. Pigmented basal cell carcinoma: increased melanin or increased melanocytes? J Cutan Pathol 2016;43:1139–42.
Danga ME, Yaar R, Bhawan J. Melan-A positive dermal cells in malignant melanoma in situ. J Cutan Pathol 2015;42:388–93.
المشرفين على المادة: TDQ283MPCW (Eosine Yellowish-(YS))
تواريخ الأحداث: Date Created: 20231208 Date Completed: 20240304 Latest Revision: 20240304
رمز التحديث: 20240304
DOI: 10.1097/DSS.0000000000004048
PMID: 38064448
قاعدة البيانات: MEDLINE
الوصف
تدمد:1524-4725
DOI:10.1097/DSS.0000000000004048