دورية أكاديمية
أعرض في EDS

Incidence, impact and predictors of residual device patency after left atrial appendage closure with the LACbes device.

التفاصيل البيبلوغرافية
العنوان: Incidence, impact and predictors of residual device patency after left atrial appendage closure with the LACbes device.
المؤلفون: Yao PC; Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Fei ZT; Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Chen M; Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Mo BF; Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Zhang R; Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Yang YL; Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Sun J; Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Wang QS; Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Li YG; Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address: liyigang@xinhuamed.com.cn.
المصدر: International journal of cardiology [Int J Cardiol] 2024 Feb 15; Vol. 397, pp. 131640. Date of Electronic Publication: 2023 Dec 06.
نوع المنشور: Clinical Trial; Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8200291 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1874-1754 (Electronic) Linking ISSN: 01675273 NLM ISO Abbreviation: Int J Cardiol Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier
Original Publication: Amsterdam : Elsevier/North-Holland Biomedical Press, c1981-
مواضيع طبية MeSH: Atrial Appendage*/diagnostic imaging , Atrial Appendage*/surgery , Atrial Fibrillation*/diagnostic imaging , Atrial Fibrillation*/surgery , Stroke*/epidemiology, Humans ; Cardiac Catheterization ; Echocardiography, Transesophageal ; Incidence ; Left Atrial Appendage Closure ; Prostheses and Implants/adverse effects ; Treatment Outcome
مستخلص: Background: The residual device patency (RDP) after left atrial appendage closure (LAAC) with the LACbes device has not been specifically explored in atrial fibrillation (AF) patients. This study aims to explore the incidence, impact and predictors of RDP detected by cardiac computed tomography angiography (CCTA) post LAAC.
Methods: AF patients implanted with the LACbes device were prospectively enrolled. CCTA device surveillance was performed at 3 months post-procedure. Major adverse events (MAEs), including stroke/transient ischemic attack, major bleeding and all-cause death, were evaluated.
Results: Among 141 patients with CCTA surveillance, 56 (39.7%) showed no visible leak and 85 (60.3%) showed RDP. During the median follow-up of 443 [232, 706] days, the presence of RDP was not associated with an increased risk of MAEs (adjusted hazard ratio [HR]: 4.07, 95% confidence interval [CI]: 0.49-34.24, p = 0.196), while peri-device leak (PDL) at the lobe was associated with heightened risks of MAEs (adjusted HR: 6.85, 95% CI: 1.62-28.89, p = 0.009). In patients with PDL at the lobe, antiplatelet after 6 months (HR: 0.20, 95% CI: 0.05-0.91, p = 0.038) was independent protective predictor of MAEs. Besides, current smoking (odds ratio [OR]: 7.52, 95% CI: 2.68-21.08, p < 0.001) and maximum diameter of LAA orifice (OR: 1.16, 95% CI: 1.00-1.34, p = 0.048) were independent predictors of PDL at the lobe.
Conclusions: Presence of PDL at the device lobe detected by CCTA at 3-month post LAAC with LACbes is associated with unfavorable prognosis in AF patients.
Clinical Trial Registration: ClinicalTrials.gov Identifier: NCT03788941.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Atrial fibrillation; Cardiac computed tomography angiography; Endothelialization; Left atrial appendage closure; Peri-device leak; Residual device patency
سلسلة جزيئية: ClinicalTrials.gov NCT03788941
تواريخ الأحداث: Date Created: 20231208 Date Completed: 20240125 Latest Revision: 20240125
رمز التحديث: 20240125
DOI: 10.1016/j.ijcard.2023.131640
PMID: 38065326
قاعدة البيانات: MEDLINE
الوصف
تدمد:1874-1754
DOI:10.1016/j.ijcard.2023.131640