دورية أكاديمية
BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility.
| العنوان: | BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility. |
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| المؤلفون: | Amaral EP; Immunobiology Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA. eduardo.amaral@nih.gov., Namasivayam S; Immunobiology Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA., Queiroz ATL; Laboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Bahia, Brazil., Fukutani E; Laboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Bahia, Brazil., Hilligan KL; Immunobiology Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA., Aberman K; Immunobiology Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA., Fisher L; Immunobiology Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine Graduate School of Medical Sciences, New York, NY, USA., Bomfim CCB; Immunobiology Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA., Kauffman K; T lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA., Buchanan J; T lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA., Santuo L; T lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA., Gazzinelli-Guimaraes PH; Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA., Costa DL; Immunobiology Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA.; Departmento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.; Programa de Pós-Graduação em Imunologia Básica e Aplicada, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil., Teixeira MA; Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, Brazil., Barreto-Duarte B; Laboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Bahia, Brazil.; Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, Brazil.; Curso de Medicina, Universidade Salvador (UNIFACS), Laureate Universities, Salvador, Bahia, Brazil., Rocha CG; Department of Pathology, School of Medicine of the Federal University of Bahia, Salvador, Bahia, Brazil.; Center for Biotechnology and Cell Therapy, D'Or Institute for Research and Education (IDOR), Sao Rafael Hospital, Salvador, Bahia, Brazil., Santana MF; Departmento de Ensino e Pesquisa, Fundação Centro de Controle de Oncologia do Estado do Amazonas-FCECON, Manaus, Amazonas, Brazil.; Fundação Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, Amazonas, Brazil.; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil., Cordeiro-Santos M; Fundação Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, Amazonas, Brazil.; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil.; Faculdade de Medicina, Universidade Nilton Lins, Manaus, Amazonas, Brazil., Barber DL; T lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA., Wilkinson RJ; Wellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; The Francis Crick Institute, London, UK.; Department of Infectious Disease, Imperial College London, London, UK., Kramnik I; Boston University School of Medicine, Boston, MA, USA., Igarashi K; Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan., Scriba T; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Observatory, South Africa., Mayer-Barber KD; Inflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD, USA., Andrade BB; Laboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Bahia, Brazil.; Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, Brazil.; Curso de Medicina, Universidade Salvador (UNIFACS), Laureate Universities, Salvador, Bahia, Brazil.; Department of Pathology, School of Medicine of the Federal University of Bahia, Salvador, Bahia, Brazil.; Curso de Medicina, Escola Bahiana de Medicina e Saúde Pública, Salvador, Bahia, Brazil.; Faculdade de Medicina, Universidade Federal da Bahia, Salvador, Bahia, Brazil.; Curso de Medicina, Universidade Faculdade de Tecnologia e Ciências (UniFTC), Salvador, Bahia, Brazil.; Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA., Sher A; Immunobiology Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA. asher@niaid.nih.gov. |
| المصدر: | Nature microbiology [Nat Microbiol] 2024 Jan; Vol. 9 (1), pp. 120-135. Date of Electronic Publication: 2023 Dec 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : Nature Publishing Group, [2016]- |
| مواضيع طبية MeSH: | Mycobacterium tuberculosis*/genetics , Tuberculosis*/microbiology , Tuberculosis, Pulmonary*/genetics, Animals ; Mice ; Basic-Leucine Zipper Transcription Factors/genetics ; Macrophages/microbiology ; Necrosis |
| مستخلص: | Oxidative stress triggers ferroptosis, a form of cellular necrosis characterized by iron-dependent lipid peroxidation, and has been implicated in Mycobacterium tuberculosis (Mtb) pathogenesis. We investigated whether Bach1, a transcription factor that represses multiple antioxidant genes, regulates host resistance to Mtb. We found that BACH1 expression is associated clinically with active pulmonary tuberculosis. Bach1 deletion in Mtb-infected mice increased glutathione levels and Gpx4 expression that inhibit lipid peroxidation. Bach1 -/- macrophages exhibited increased resistance to Mtb-induced cell death, while Mtb-infected Bach1-deficient mice displayed reduced bacterial loads, pulmonary necrosis and lipid peroxidation concurrent with increased survival. Single-cell RNA-seq analysis of lungs from Mtb-infected Bach1 -/- mice revealed an enrichment of genes associated with ferroptosis suppression. Bach1 depletion in Mtb-infected B6.Sst1 S mice that display human-like necrotic lung pathology also markedly reduced necrosis and increased host resistance. These findings identify Bach1 as a key regulator of cellular and tissue necrosis and host resistance in Mtb infection. (© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.) |
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| معلومات مُعتمدة: | United Kingdom WT_ Wellcome Trust; CC2112 United Kingdom ARC_ Arthritis Research UK; R01 HL126066 United States HL NHLBI NIH HHS; U01 AI115940 United States AI NIAID NIH HHS |
| المشرفين على المادة: | 0 (Basic-Leucine Zipper Transcription Factors) 0 (Bach1 protein, mouse) |
| تواريخ الأحداث: | Date Created: 20231208 Date Completed: 20240108 Latest Revision: 20240214 |
| رمز التحديث: | 20240215 |
| مُعرف محوري في PubMed: | PMC10769877 |
| DOI: | 10.1038/s41564-023-01523-7 |
| PMID: | 38066332 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2058-5276 |
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| DOI: | 10.1038/s41564-023-01523-7 |