دورية أكاديمية
أعرض في EDS

Regular Practice of Physical Activity Improves Cholesterol Transfers to High-Density Lipoprotein (HDL) and Other HDL Metabolic Parameters in Older Adults.

التفاصيل البيبلوغرافية
العنوان: Regular Practice of Physical Activity Improves Cholesterol Transfers to High-Density Lipoprotein (HDL) and Other HDL Metabolic Parameters in Older Adults.
المؤلفون: Braga PGS; Instituto do Coracao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, Brazil., Freitas FR; Instituto do Coracao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, Brazil., Bachi ALL; Post-Graduation Program in Health Sciences, Santo Amaro University (UNISA), Sao Paulo 04829-300, Brazil., Amirato GR; Centro Educacional e Esportivo Mane Garrincha, Secretaria Municipal de Esportes, Lazer e Recreacao, Sao Paulo 04039-034, Brazil., Baroni RV; Instituto do Coracao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, Brazil., Alves MJNN; Instituto do Coracao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, Brazil., Vieira RP; Post-Graduate Program in Sciences of Human Movement and Rehabilitation, Universidade Federal de Sao Paulo (UNIFESP), Santos 11060-001, Brazil.; Post-Graduate Program in Human Movement and Rehabilitation and in Pharmaceutical Sciences, Evangelical University of Goiás (Unievangélica), Anápolis 75083-515, Brazil.; Post-Graduate Program in Bioengineering, Universidade Brasil, São Paulo 08230-030, Brazil., Vaisberg MW; Departamento de Medicina, Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo 04023-062, Brazil., Aldin MN; Departamento de Nutricao, Faculdade de Saude Publica da Universidade de São Paulo (FSP-USP), Sao Paulo 01246-904, Brazil., Kalil Filho R; Instituto do Coracao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, Brazil., Figueiredo Neto AM; Instituto de Fisica (IF), Universidade de Sao Paulo, Sao Paulo 05508-090, Brazil., Damasceno NRT; Departamento de Nutricao, Faculdade de Saude Publica da Universidade de São Paulo (FSP-USP), Sao Paulo 01246-904, Brazil., Tavoni TM; Instituto do Coracao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, Brazil., Maranhão RC; Instituto do Coracao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, Brazil.; Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, Sao Paulo 05508-000, Brazil.
المصدر: Nutrients [Nutrients] 2023 Nov 22; Vol. 15 (23). Date of Electronic Publication: 2023 Nov 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Lipoproteins, HDL* , Antioxidants*, Humans ; Aged ; Aryldialkylphosphatase ; Cholesterol ; Cholesterol Esters ; Exercise ; Cholesterol, HDL
مستخلص: The effects of regular physical activity on two important anti-atherosclerosis functions of high-density lipoprotein (HDL), namely its capacity to receive both forms of cholesterol and its anti-oxidant function, were investigated in this study comparing older adults with young individuals. One-hundred and eight healthy adult individuals were enrolled and separated into the following groups: active older (60-80 yrs, n = 24); inactive older (60-79 yrs, n = 21); active young (20-34 yrs, n = 39); and inactive young (20-35 yrs, n = 24). All performed cardiopulmonary tests. Blood samples were collected in order to assess the following measures: lipid profile, HDL anti-oxidant capacity, paraoxonase-1 activity, HDL subfractions, and lipid transfer to HDL. Comparing active older and active young groups with inactive older and inactive young groups, respectively, the active groups presented higher HDL-C levels ( p < 0.01 for both comparisons), unesterified cholesterol transfer ( p < 0.01, p < 0.05), and intermediate and larger HDL subfractions ( p < 0.001, p < 0.01) than the respective inactive groups. In addition, the active young group showed higher esterified cholesterol transfer than the inactive young group ( p < 0.05). As expected, the two active groups had higher VO 2 peak than the inactive groups; VO 2 peak was higher in the two younger than in the two older groups ( p < 0.05). No differences in unesterified and esterified cholesterol transfers and HDL subfractions were found between active young and active older groups. HDL anti-oxidant capacity and paraoxonase-1 activity were equal in all four study groups. Our data highlight and strengthen the benefits of regular practice of physical activity on an important HDL function, the capacity of HDL to receive cholesterol, despite the age-dependent decrease in VO 2 peak.
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معلومات مُعتمدة: 2014/03742-0 São Paulo Research Foundation
فهرسة مساهمة: Keywords: HDL function; HDL metabolism; aging; cholesterol; physical activity
المشرفين على المادة: 0 (Lipoproteins, HDL)
0 (Antioxidants)
EC 3.1.8.1 (Aryldialkylphosphatase)
97C5T2UQ7J (Cholesterol)
0 (Cholesterol Esters)
0 (Cholesterol, HDL)
تواريخ الأحداث: Date Created: 20231209 Date Completed: 20231216 Latest Revision: 20231216
رمز التحديث: 20231217
مُعرف محوري في PubMed: PMC10708266
DOI: 10.3390/nu15234871
PMID: 38068730
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu15234871