دورية أكاديمية
A role for MCH neuron firing in modulating hippocampal plasticity threshold.
| العنوان: | A role for MCH neuron firing in modulating hippocampal plasticity threshold. |
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| المؤلفون: | Harris JJ; Sensory Circuits and Neurotechnology Laboratory, Francis Crick Institute, London, UK; Department of Life Sciences, Imperial College London, London, UK; System Neuroscience and Energy Control Laboratory, Francis Crick Institute, London, UK. Electronic address: julia.harris@crick.ac.uk., Burdakov D; System Neuroscience and Energy Control Laboratory, Francis Crick Institute, London, UK; Department of Health Sciences and Technology, ETH Zürich, 8603 Schwerzenbach, Switzerland; Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zürich, 8603 Schwerzenbach, Switzerland; Institute of Food Nutrition and Health, Department of Health Sciences and Technology, ETH Zürich, 8603 Schwerzenbach, Switzerland; Neuroscience Center Zürich, 8057 Zürich, Switzerland. Electronic address: denis.burdakov@hest.ethz.ch. |
| المصدر: | Peptides [Peptides] 2024 Feb; Vol. 172, pp. 171128. Date of Electronic Publication: 2023 Dec 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Inc Country of Publication: United States NLM ID: 8008690 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5169 (Electronic) Linking ISSN: 01969781 NLM ISO Abbreviation: Peptides Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Elsevier Science Inc. Original Publication: Fayetteville, N. Y., Ankho International. |
| مواضيع طبية MeSH: | Hypothalamic Hormones*/metabolism, Hippocampus/metabolism ; Pituitary Hormones ; Neurons/metabolism ; Melanins |
| مستخلص: | It has been revealed that hypothalamic neurons containing the peptide, melanin-concentrating hormone (MCH) can influence learning [1] and memory formation [2], but the cellular mechanisms by which they perform this function are not well understood. Here, we examine the role of MCH neural input to the hippocampus, and show in vitro that optogenetically increasing MCH axon activity facilitates hippocampal plasticity by lowering the threshold for synaptic potentiation. These results align with increasing evidence that MCH neurons play a regulatory role in learning, and reveal that this could be achieved by modulating plasticity thresholds in the hippocampus. (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Hippocampus; MCH; Melanin-concentrating hormone; Optogenetics; Synaptic plasticity |
| المشرفين على المادة: | 67382-96-1 (melanin-concentrating hormone) 0 (Hypothalamic Hormones) 0 (Pituitary Hormones) 0 (Melanins) |
| تواريخ الأحداث: | Date Created: 20231209 Date Completed: 20240125 Latest Revision: 20240125 |
| رمز التحديث: | 20240125 |
| DOI: | 10.1016/j.peptides.2023.171128 |
| PMID: | 38070684 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-5169 |
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| DOI: | 10.1016/j.peptides.2023.171128 |