دورية أكاديمية
Molecular and functional insight into focal adhesion kinases: Therapeutic implications for oral malignancies.
| العنوان: | Molecular and functional insight into focal adhesion kinases: Therapeutic implications for oral malignancies. |
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| المؤلفون: | Prasad P; Basic Medical and Dental Sciences Department, College of Dentistry, Ajman University, Ajman, United Arab Emirates; Center of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates., Billah Khair AM; Basic Medical and Dental Sciences Department, College of Dentistry, Ajman University, Ajman, United Arab Emirates; Center of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates., Venkatesan K; Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia., Shahwan M; Center of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates; College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab Emirates., Shamsi A; Center of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates. Electronic address: m.shamsi@ajman.ac.ae. |
| المصدر: | Drug discovery today [Drug Discov Today] 2024 Jan; Vol. 29 (1), pp. 103852. Date of Electronic Publication: 2023 Dec 08. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd. Country of Publication: England NLM ID: 9604391 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5832 (Electronic) Linking ISSN: 13596446 NLM ISO Abbreviation: Drug Discov Today Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kidlington, Oxford : Irvington, NJ : Elsevier Science Ltd. ; Distributed by Virgin Mailing and Distribution, c1996- |
| مواضيع طبية MeSH: | Focal Adhesions*/metabolism , Focal Adhesions*/pathology , Mouth Neoplasms*/drug therapy , Mouth Neoplasms*/pathology, Humans ; Focal Adhesion Protein-Tyrosine Kinases/metabolism ; Biomarkers |
| مستخلص: | Oral carcinoma is the sixth most common cancer globally, with one death occurring every hour. Focal adhesion kinase (FAK) is an intercellular protein tyrosine kinase, a key indicator of the development of oral cancer. FAK overexpression leads to the initiation and significant progression of metastasis in head and neck cancers, indicating its vital role in cancer progression and potential as a biomarker for early oral malignant transformation. The present review elaborates on FAK's function in oral malignancies since it could serve as a biomarker of the initial stages of oral malignant transformation and a possible predictive factor for risk assessment. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: biomarker; cancer therapeutics; focal adhesion kinase; oral cancer |
| المشرفين على المادة: | EC 2.7.10.2 (Focal Adhesion Protein-Tyrosine Kinases) 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20231209 Date Completed: 20240108 Latest Revision: 20240108 |
| رمز التحديث: | 20240108 |
| DOI: | 10.1016/j.drudis.2023.103852 |
| PMID: | 38070702 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-5832 |
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| DOI: | 10.1016/j.drudis.2023.103852 |