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Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity.

التفاصيل البيبلوغرافية
العنوان: Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity.
المؤلفون: Duan J; NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.; Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China.; School of Public Health, Tianjin Medical University, Tianjin, China., Dong W; NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.; Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China., Wang G; NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.; Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China.; The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, Tianjin, China., Xiu W; NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.; Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China., Pu G; NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.; Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China., Xu J; NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.; Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China., Ye C; Henan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, China., Zhang X; The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, Tianjin, China. xuzhang@tmu.edu.cn., Zhu Y; Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China. zhuyi@tmu.edu.cn.; The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, Tianjin, China. zhuyi@tmu.edu.cn., Wang C; NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China. wangchunjiong@tmu.edu.cn.; Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China. wangchunjiong@tmu.edu.cn.; Tianjin Key Laboratory of Medical Epigenetics, Tianjin Medical University, Tianjin, China. wangchunjiong@tmu.edu.cn.
المصدر: Nature communications [Nat Commun] 2023 Dec 09; Vol. 14 (1), pp. 8151. Date of Electronic Publication: 2023 Dec 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Linoleic Acids*/metabolism , Fatty Liver*, Male ; Mice ; Animals ; Catalase ; Linoleic Acid ; Liver/metabolism
مستخلص: Aging is a major risk factor for metabolic disorders. Polyunsaturated fatty acid-derived bioactive lipids play critical roles as signaling molecules in metabolic processes. Nonetheless, their effects on age-related liver steatosis remain unknown. Here we show that senescent liver cells induce liver steatosis in a paracrine manner. Linoleic acid-derived 9-hydroxy-octadecadienoic acid (9-HODE) and 13-HODE increase in middle-aged (12-month-old) and aged (20-month-old) male mouse livers and conditioned medium from senescent hepatocytes and macrophages. Arachidonate 15-lipoxygenase, an enzyme for 13-HODE and 9-HODE production, is upregulated in senescent cells. A 9-HODE and 13-HODE mixture induces liver steatosis and activates SREBP1. Furthermore, catalase (CAT) is a direct target of 13-HODE, and its activity is decreased by 13-HODE. CAT overexpression reduces 13-HODE-induced liver steatosis and protects male mice against age-related liver steatosis. Therefore, 13-HODE produced by senescent hepatocytes and macrophages activates SREBP1 by directly inhibiting CAT activity and promotes liver steatosis.
(© 2023. The Author(s).)
References: Front Physiol. 2021 May 25;12:646491. (PMID: 34113260)
Nucleic Acids Res. 2022 Jul 5;50(W1):W216-W221. (PMID: 35325185)
Nat Rev Gastroenterol Hepatol. 2018 Jan;15(1):11-20. (PMID: 28930295)
Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12027-32. (PMID: 14512514)
J Clin Invest. 2022 Aug 1;132(15):. (PMID: 35912854)
Cell Commun Signal. 2022 Dec 6;20(1):192. (PMID: 36474295)
Appl Microbiol Biotechnol. 2003 Jun;61(5-6):488-94. (PMID: 12764563)
Prog Lipid Res. 2012 Jul;51(3):267-71. (PMID: 22266797)
JHEP Rep. 2021 May 01;3(4):100301. (PMID: 34113839)
Acta Pharmacol Sin. 2020 Jan;41(1):138-144. (PMID: 31263275)
Oncogene. 2016 Feb 4;35(5):642-50. (PMID: 25893295)
Physiol Rev. 2021 Jul 1;101(3):1371-1426. (PMID: 33599151)
Ther Adv Endocrinol Metab. 2010 Apr;1(2):51-60. (PMID: 23148150)
Eur J Pharmacol. 2016 Aug 15;785:70-76. (PMID: 25987423)
Lancet Gastroenterol Hepatol. 2022 Sep;7(9):851-861. (PMID: 35798021)
Cell Metab. 2020 Nov 3;32(5):814-828.e6. (PMID: 32949498)
Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6806-E6812. (PMID: 27698118)
Trends Cell Biol. 2020 Aug;30(8):628-639. (PMID: 32505550)
Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Apr;1868(4):159287. (PMID: 36690321)
Pflugers Arch. 2018 Dec;470(12):1721-1737. (PMID: 30120555)
Cell. 2023 Jan 19;186(2):243-278. (PMID: 36599349)
Free Radic Biol Med. 2015 May;82:105-13. (PMID: 25659933)
Aging Cell. 2019 Apr;18(2):e12895. (PMID: 30609251)
Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3181-3185. (PMID: 28270609)
Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13353-8. (PMID: 19666541)
J Lipid Res. 2010 Oct;51(10):3046-54. (PMID: 20631297)
Prostaglandins Other Lipid Mediat. 2012 Oct;99(1-2):51-6. (PMID: 22706383)
Hepatology. 2018 Jan;67(1):328-357. (PMID: 28714183)
Trends Cell Biol. 2021 Mar;31(3):148-151. (PMID: 33422360)
Cell Mol Gastroenterol Hepatol. 2019;8(1):73-94. (PMID: 30878663)
Sci Rep. 2017 Aug 21;7(1):8976. (PMID: 28827690)
J Mol Biol. 2000 Feb 11;296(1):295-309. (PMID: 10656833)
J Hepatol. 2018 Oct;69(4):896-904. (PMID: 29886156)
Bioinformatics. 2020 Apr 15;36(8):2628-2629. (PMID: 31882993)
Science. 2003 May 16;300(5622):1140-2. (PMID: 12750520)
Prog Biophys Mol Biol. 2018 Dec;140:5-12. (PMID: 29530789)
Hepatology. 2016 Jul;64(1):92-105. (PMID: 26928949)
Cell. 1998 Apr 17;93(2):229-40. (PMID: 9568715)
Nat Struct Mol Biol. 2008 Sep;15(9):924-31. (PMID: 19172745)
Hepatology. 2013 Aug;58(2):617-28. (PMID: 23348573)
Int J Mol Sci. 2020 Dec 17;21(24):. (PMID: 33348841)
Free Radic Biol Med. 2017 Feb;103:48-56. (PMID: 27939935)
Sci Rep. 2021 Mar 31;11(1):7300. (PMID: 33790341)
CNS Neurosci Ther. 2023 Jul;29(7):1923-1939. (PMID: 36942513)
Prostaglandins Leukot Essent Fatty Acids. 2006 May;74(5):283-93. (PMID: 16647253)
Free Radic Biol Med. 2013 Dec;65:952-968. (PMID: 23994574)
Prog Lipid Res. 2019 Jan;73:28-45. (PMID: 30472260)
Nat Rev Endocrinol. 2017 Dec;13(12):710-730. (PMID: 28849786)
J Biol Chem. 2005 Dec 9;280(49):40676-83. (PMID: 16236715)
Annu Rev Physiol. 2013;75:685-705. (PMID: 23140366)
Am J Physiol Endocrinol Metab. 2017 Nov 1;313(5):E586-E597. (PMID: 28811294)
J Invest Dermatol. 2008 May;128(5):1123-33. (PMID: 18034171)
Nat Commun. 2017 Jun 13;8:15691. (PMID: 28608850)
Circulation. 2013 Apr 23;127(16):1664-76. (PMID: 23513067)
Nature. 2019 Jul;571(7764):183-192. (PMID: 31292558)
Clin Exp Pharmacol Physiol. 2018 Jan;45(1):98-108. (PMID: 28755503)
Free Radic Biol Med. 2014 Feb;67:255-64. (PMID: 24211614)
Semin Liver Dis. 2020 Nov;40(4):373-384. (PMID: 33764489)
Br J Pharmacol. 2017 Jul;174(14):2358-2372. (PMID: 28471490)
Nature. 1999 Jul 22;400(6742):378-82. (PMID: 10432118)
Autophagy. 2020 Nov;16(11):2004-2016. (PMID: 31931659)
Hepatology. 2010 Dec;52(6):1980-91. (PMID: 20967760)
Nat Rev Endocrinol. 2021 May;17(5):276-295. (PMID: 33627836)
Am J Pathol. 2017 Oct;187(10):2232-2245. (PMID: 28923202)
Science. 2015 May 8;348(6235):648-60. (PMID: 25954001)
Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):66-72. (PMID: 19063986)
J Proteome Res. 2015 Apr 3;14(4):1843-53. (PMID: 25736083)
Cell Metab. 2021 Jun 1;33(6):1124-1136.e5. (PMID: 33811820)
Free Radic Biol Med. 2020 Feb 20;148:22-32. (PMID: 31877356)
Acta Pharmacol Sin. 2018 Jul;39(7):1142-1154. (PMID: 29877318)
J Lipid Res. 2008 Nov;49(11):2283-301. (PMID: 18757836)
J Clin Endocrinol Metab. 2004 Aug;89(8):3864-71. (PMID: 15292319)
معلومات مُعتمدة: 81822006 National Natural Science Foundation of China (National Science Foundation of China); 82170635 National Natural Science Foundation of China (National Science Foundation of China); 82127808 National Natural Science Foundation of China (National Science Foundation of China)
المشرفين على المادة: 5204-88-6 (13-hydroxy-9,11-octadecadienoic acid)
EC 1.11.1.6 (Catalase)
0 (Linoleic Acids)
9KJL21T0QJ (Linoleic Acid)
تواريخ الأحداث: Date Created: 20231209 Date Completed: 20231216 Latest Revision: 20231216
رمز التحديث: 20231218
مُعرف محوري في PubMed: PMC10710422
DOI: 10.1038/s41467-023-44026-z
PMID: 38071367
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-023-44026-z