دورية أكاديمية
Repopulating Kupffer cells originate directly from hematopoietic stem cells.
| العنوان: | Repopulating Kupffer cells originate directly from hematopoietic stem cells. |
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| المؤلفون: | Fan X; State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China.; Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis and National Clinical Research Center of Digestive Diseases, Beijing, 100050, China., Lu P; Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis and National Clinical Research Center of Digestive Diseases, Beijing, 100050, China., Cui XH; Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis and National Clinical Research Center of Digestive Diseases, Beijing, 100050, China., Wu P; State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China., Lin WR; State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China., Zhang D; Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Tolerance Induction and Organ Protection in Transplantation, Beijing, 10050, China., Yuan SZ; Department of Lymphoma, Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100071, China., Liu B; State Key Laboratory of Experimental Hematology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100071, China., Chen FY; State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China., You H; Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis and National Clinical Research Center of Digestive Diseases, Beijing, 100050, China., Wei HD; State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China., He FC; State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China. hefc@bmi.ac.cn.; Research Unit of Proteomics Driven Cancer Precision Medicine, Chinese Academy of Medical Sciences, Beijing, 102206, China. hefc@bmi.ac.cn., Jia JD; Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis and National Clinical Research Center of Digestive Diseases, Beijing, 100050, China. jia_jd@ccmu.edu.cn., Jiang Y; State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China. jiangying304@hotmail.com.; Anhui Medical University, Hefei, 230032, China. jiangying304@hotmail.com. |
| المصدر: | Stem cell research & therapy [Stem Cell Res Ther] 2023 Dec 10; Vol. 14 (1), pp. 351. Date of Electronic Publication: 2023 Dec 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central |
| مواضيع طبية MeSH: | Kupffer Cells* , Hematopoietic Stem Cells*, Mice ; Animals ; Liver ; Monocytes ; Inflammation |
| مستخلص: | Background: Kupffer cells (KCs) originate from yolk-sac progenitors before birth. Throughout adulthood, they self-maintain independently from the input of circulating monocytes (MOs) at a steady state and are replenished within 2 weeks after having been depleted, but the origin of repopulating KCs in adults remains unclear. The current paradigm dictates that repopulating KCs originate from preexisting KCs or monocytes, but there remains a lack of fate-mapping evidence. Methods: We first traced the fate of preexisting KCs and that of monocytic cells with tissue-resident macrophage-specific and monocytic cell-specific fate-mapping mouse models, respectively. Secondly, we performed genetic lineage tracing to determine the type of progenitor cells involved in response to KC-depletion in mice. Finally, we traced the fate of hematopoietic stem cells (HSCs) in an HSC-specific fate-mapping mouse model, in the context of chronic liver inflammation induced by repeated carbon tetrachloride treatment. Results: By using fate-mapping mouse models, we found no evidence that repopulating KCs originate from preexisting KCs or MOs and found that in response to KC-depletion, HSCs proliferated in the bone marrow, mobilized into the blood, adoptively transferred into the liver and differentiated into KCs. Then, in the chronic liver inflammation context, we confirmed that repopulating KCs originated directly from HSCs. Conclusion: Taken together, these findings provided in vivo fate-mapping evidence that repopulating KCs originate directly from HSCs, which presents a completely novel understanding of the cellular origin of repopulating KCs and shedding light on the divergent roles of KCs in liver homeostasis and diseases. (© 2023. The Author(s).) |
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| معلومات مُعتمدة: | 2018YFA0507502 National Key R&D Program of China |
| فهرسة مساهمة: | Keywords: Chronic liver inflammation; Differentiation; Genetic inducible fate-mapping; Hematopoietic stem cells; Kupffer cells; Monocytic cells; Progenitor cells; Proliferation; Repopulation; Self-maintain |
| تواريخ الأحداث: | Date Created: 20231210 Date Completed: 20231216 Latest Revision: 20240125 |
| رمز التحديث: | 20240126 |
| مُعرف محوري في PubMed: | PMC10712046 |
| DOI: | 10.1186/s13287-023-03569-0 |
| PMID: | 38072929 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1757-6512 |
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| DOI: | 10.1186/s13287-023-03569-0 |