Persistent immune imprinting after XBB.1.5 COVID vaccination in humans.
| العنوان: | Persistent immune imprinting after XBB.1.5 COVID vaccination in humans. |
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| المؤلفون: | Tortorici MA; Department of Biochemistry, University of Washington, Seattle, WA, USA., Addetia A; Department of Biochemistry, University of Washington, Seattle, WA, USA., Seo AJ; Department of Biochemistry, University of Washington, Seattle, WA, USA., Brown J; Department of Biochemistry, University of Washington, Seattle, WA, USA., Sprouse KR; Department of Biochemistry, University of Washington, Seattle, WA, USA., Logue J; Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA., Clark E; Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA., Franko N; Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA., Chu H; Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA., Veesler D; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. |
| المصدر: | BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 30. Date of Electronic Publication: 2023 Nov 30. |
| نوع المنشور: | Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: | Immune imprinting - also known as 'original antigenic sin' - describes how the first exposure to a virus shapes the immunological outcome of subsequent exposures to antigenically related strains. SARS-CoV-2 Omicron breakthrough infections and bivalent COVID-19 vaccination were shown to primarily recall cross-reactive memory B cells and antibodies induced by prior mRNA vaccination with the Wuhan-Hu-1 spike rather than priming naive B cells that recognize Omicron-specific epitopes. These findings underscored a strong immune imprinting resulting from repeated Wuhan-Hu-1 spike exposures. To understand if immune imprinting can be overcome, we investigated memory and plasma antibody responses after administration of the updated XBB.1.5 COVID mRNA vaccine booster. Our data show that the XBB.1.5 booster elicits neutralizing antibody responses against current variants that are dominated by recall of pre-existing memory B cells previously induced by the Wuhan-Hu-1 spike. These results indicate that immune imprinting persists even after multiple exposures to Omicron spikes through vaccination and infection, including post XBB.1.5 spike booster mRNA vaccination, which will need to be considered to guide the design of future vaccine boosters. |
| التعليقات: | Update in: Immunity. 2024 Mar 8;:. (PMID: 38490197) |
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| معلومات مُعتمدة: | 75N93022C00036 United States AI NIAID NIH HHS; DP1 AI158186 United States AI NIAID NIH HHS; P01 AI167966 United States AI NIAID NIH HHS |
| تواريخ الأحداث: | Date Created: 20231211 Latest Revision: 20240410 |
| رمز التحديث: | 20240411 |
| مُعرف محوري في PubMed: | PMC10705481 |
| DOI: | 10.1101/2023.11.28.569129 |
| PMID: | 38076876 |
| قاعدة البيانات: | MEDLINE |
| DOI: | 10.1101/2023.11.28.569129 |
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