دورية أكاديمية
ROS production by mitochondria: function or dysfunction?
العنوان: | ROS production by mitochondria: function or dysfunction? |
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المؤلفون: | Palma FR; Department of Medicine, Division of Hematology Oncology, Feinberg School of Medicine and the Robert H. Lurie Comprehensive Cancer Center of Chicago, Northwestern University, Chicago, IL, USA., Gantner BN; Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA., Sakiyama MJ; Department of Medicine, Division of Hematology Oncology, Feinberg School of Medicine and the Robert H. Lurie Comprehensive Cancer Center of Chicago, Northwestern University, Chicago, IL, USA., Kayzuka C; Department of Pharmacology, Ribeirao Preto College of Nursing, University of Sao Paulo, Sao Paulo, Brazil., Shukla S; Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, India., Lacchini R; Department of Psychiatric Nursing and Human Sciences, Ribeirao Preto College of Nursing, University of Sao Paulo, Sao Paulo, Brazil., Cunniff B; Department of Pathology and Laboratory Medicine, Larner School of Medicine, University of Vermont, Burlington, VT, USA., Bonini MG; Department of Medicine, Division of Hematology Oncology, Feinberg School of Medicine and the Robert H. Lurie Comprehensive Cancer Center of Chicago, Northwestern University, Chicago, IL, USA. Marcelo.bonini@northwestern.edu. |
المصدر: | Oncogene [Oncogene] 2024 Jan; Vol. 43 (5), pp. 295-303. Date of Electronic Publication: 2023 Dec 11. |
نوع المنشور: | Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2002->: Basingstoke : Nature Publishing Group Original Publication: Basingstoke, Hampshire, UK : Scientific & Medical Division, MacMillan Press, c1987- |
مواضيع طبية MeSH: | Mitochondria*/metabolism , Oxidative Stress*, Humans ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Adenosine Triphosphate/metabolism |
مستخلص: | In eukaryotic cells, ATP generation is generally viewed as the primary function of mitochondria under normoxic conditions. Reactive oxygen species (ROS), in contrast, are regarded as the by-products of respiration, and are widely associated with dysfunction and disease. Important signaling functions have been demonstrated for mitochondrial ROS in recent years. Still, their chemical reactivity and capacity to elicit oxidative damage have reinforced the idea that ROS are the products of dysfunctional mitochondria that accumulate during disease. Several studies support a different model, however, by showing that: (1) limited oxygen availability results in mitochondria prioritizing ROS production over ATP, (2) ROS is an essential adaptive mitochondrial signal triggered by various important stressors, and (3) while mitochondria-independent ATP production can be easily engaged by most cells, there is no known replacement for ROS-driven redox signaling. Based on these observations and other evidence reviewed here, we highlight the role of ROS production as a major mitochondrial function involved in cellular adaptation and stress resistance. As such, we propose a rekindled view of ROS production as a primary mitochondrial function as essential to life as ATP production itself. (© 2023. The Author(s), under exclusive licence to Springer Nature Limited.) |
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معلومات مُعتمدة: | R01ES028149 U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS); R56033398 U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS); R01HL163820 U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI); R01CA216882 U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) |
المشرفين على المادة: | 0 (Reactive Oxygen Species) 8L70Q75FXE (Adenosine Triphosphate) |
تواريخ الأحداث: | Date Created: 20231211 Date Completed: 20240131 Latest Revision: 20240815 |
رمز التحديث: | 20240816 |
DOI: | 10.1038/s41388-023-02907-z |
PMID: | 38081963 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1476-5594 |
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DOI: | 10.1038/s41388-023-02907-z |