دورية أكاديمية
Functional polymeric molecules for performing autonomous synthesis of particles with core-shell structures and customizable shapes.
| العنوان: | Functional polymeric molecules for performing autonomous synthesis of particles with core-shell structures and customizable shapes. |
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| المؤلفون: | Chen L; Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore. chessl@nus.edu.sg.; Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, P. R. China., Low HR; Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore. chessl@nus.edu.sg., Jiang Y; Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore. chessl@nus.edu.sg., Zhang WY; Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore. chessl@nus.edu.sg., Ao CK; Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore. chessl@nus.edu.sg., Tan YJN; Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore. chessl@nus.edu.sg., Lim KH; Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore. chessl@nus.edu.sg., Soh S; Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore. chessl@nus.edu.sg. |
| المصدر: | Materials horizons [Mater Horiz] 2024 Feb 19; Vol. 11 (4), pp. 1054-1064. Date of Electronic Publication: 2024 Feb 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101623537 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-6355 (Electronic) Linking ISSN: 20516347 NLM ISO Abbreviation: Mater Horiz Subsets: PubMed not MEDLINE; MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge : Royal Society of Chemistry, [2014]- |
| مستخلص: | Self-organization by the directed migration of components within a system is an important process in many applications, such as the unidirectional migration of motor proteins for transporting items to specific sites in a cell. This manuscript describes a class of functional polymeric molecules that have a set of instructions written by specific chemical moieties. These instructions allow the functional polymeric molecules to be used for autonomous synthesis of particles: particles with both functional core-shell structure and customizable shapes are fabricated for the first time. The functional polymeric molecules direct the large-scale migration of the liquid molecules to specific sites for forming the required customized structure of the particle, thus overcoming previous challenges of fabricating this class of particles. This first synthesis of this class of particles enables the development of novel applications: the concept of shape specificity for targeting sites. Both the basic structural properties (core-shell structure and customizable shape) are used in the specific applications of targeted drug delivery and imaging. The secure physical fit due to the complementary shapes enables the particles to remain locked in position for the targeting. Polymeric molecules are first shown to be highly capable of being encoded with instructions for autonomous synthesis of structured materials. |
| تواريخ الأحداث: | Date Created: 20231212 Latest Revision: 20240219 |
| رمز التحديث: | 20240219 |
| DOI: | 10.1039/d3mh01480k |
| PMID: | 38084052 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2051-6355 |
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| DOI: | 10.1039/d3mh01480k |