دورية أكاديمية
Study the Effect of Calendula officinalis Extract Loaded on Zinc Oxide Nanoparticle Cream in Burn Wound Healing.
| العنوان: | Study the Effect of Calendula officinalis Extract Loaded on Zinc Oxide Nanoparticle Cream in Burn Wound Healing. |
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| المؤلفون: | Hashemi SS; Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran., Pakdin A; Division of Plastic and Reconstructive Surgery, Department of Surgery, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran., Mohammadi A; Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran.; Division of Plastic and Reconstructive Surgery, Department of Surgery, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran., Keshavarzi A; Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran., Mortazavi M; Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman 76318-85356, Iran., Sanati P; Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran. |
| المصدر: | ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2023 Dec 27; Vol. 15 (51), pp. 59269-59279. Date of Electronic Publication: 2023 Dec 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, D.C. : American Chemical Society |
| مواضيع طبية MeSH: | Zinc Oxide*/pharmacology , Zinc Oxide*/chemistry , Calendula*/chemistry , Nanoparticles* , Anti-Infective Agents*/pharmacology , Burns*/drug therapy, Rats ; Animals ; bcl-2-Associated X Protein ; Rats, Wistar ; Wound Healing |
| مستخلص: | The skin, the body's largest organ, acts as a protective barrier against pathogens and environmental damage. Skin burns can result from heat, chemicals, friction, or electricity. Nanoscience has recently been utilized to create ointments and creams for burns. Zinc oxide nanoparticles are crucial due to their antimicrobial and antioxidant properties. In this study, a cream containing nanoparticles was loaded with calendula extract, and its ability to promote tissue healing was investigated in Wistar rats with skin burns. The zinc oxide nanoparticles were chemically synthesized and loaded with calendula extract. The morphology and physicochemical properties of the nanoparticles were confirmed by SEM, ZETA size, XRD, and FTIR assays. The MTT technique was employed to assess the cream's impact on fibroblast growth. The antimicrobial activity of the nanoparticles was investigated against Pseudomonas using the MIC method. Real-time PCR was used to determine the expression of the Bax and Bcl-2 genes in aeruginosa . The results showed that zinc oxide nanoparticles at high concentrations increased the proliferation of the fibroblast cells. Histopathological studies showed granulation and epithelialization of the tissue without any hemorrhage or tissue infection during the first days of treatment with this cream. The animal models treated with the cream showed an increase in Bcl-2 gene expression and a decrease in Bax expression. We concluded that zinc oxide nanoparticles loaded with calendula extract have a practical effect in healing burn wounds due to their unique antibacterial properties of zinc oxide nanoparticles and their anti-inflammatory and wound-healing effects. The synergistic effect of these two substances significantly improved the healing process. This newly developed cream can be introduced as a successful and viable treatment option in burn wounds. |
| فهرسة مساهمة: | Keywords: antimicrobial; burn recovery; calendula extract; epithelialization; zinc-oxide nanoparticles |
| المشرفين على المادة: | SOI2LOH54Z (Zinc Oxide) 0 (bcl-2-Associated X Protein) 0 (Anti-Infective Agents) |
| تواريخ الأحداث: | Date Created: 20231212 Date Completed: 20231228 Latest Revision: 20231228 |
| رمز التحديث: | 20231228 |
| DOI: | 10.1021/acsami.3c17350 |
| PMID: | 38085997 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1944-8252 |
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| DOI: | 10.1021/acsami.3c17350 |