The correlation between soluble human leukocyte antigen (sHLA-G) levels and +3010 polymorphism.

التفاصيل البيبلوغرافية
العنوان:	The correlation between soluble human leukocyte antigen (sHLA-G) levels and +3010 polymorphism.
المؤلفون:	Alyami A; Pathology and Clinical Laboratory Medicine Administration, King Fahad Medical City, Riyadh Second Health Cluster, Riyadh, Saudi Arabia., AlJurayyan A; Pathology and Clinical Laboratory Medicine Administration, King Fahad Medical City, Riyadh Second Health Cluster, Riyadh, Saudi Arabia., Alosaimi B; Research Center, King Fahad Medical City Riyadh Second Health Cluster, Riyadh, Saudi Arabia., Alkadi H; Research Center, King Fahad Medical City Riyadh Second Health Cluster, Riyadh, Saudi Arabia., Alkhulaifi F; College of Science, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia., Al-Jurayb H; Pathology and Clinical Laboratory Medicine Administration, King Fahad Medical City, Riyadh Second Health Cluster, Riyadh, Saudi Arabia., Osman A; Pathology and Clinical Laboratory Medicine Administration, King Fahad Medical City, Riyadh Second Health Cluster, Riyadh, Saudi Arabia., Christmas S; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Alomar S; College of Science, King Saud University, Riyadh, Saudi Arabia., Al-Bayati Z; Department of Genetic Study, Azadi Teaching Hospital, Kirkuk, Iraq.
المصدر:	International journal of immunogenetics [Int J Immunogenet] 2024 Feb; Vol. 51 (1), pp. 39-46. Date of Electronic Publication: 2023 Dec 12.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Blackwell Pub Country of Publication: England NLM ID: 101232337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-313X (Electronic) Linking ISSN: 17443121 NLM ISO Abbreviation: Int J Immunogenet Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Oxford, UK : Blackwell Pub., c2005-
مواضيع طبية MeSH:	HLA-G Antigens/genetics , Polymorphism, Single Nucleotide, Humans ; Genotype ; 3' Untranslated Regions/genetics ; Histocompatibility Antigens Class II/genetics ; Gene Frequency
مستخلص:	Human leukocyte antigen-G (HLA-G) is classified as non-classical HLA, located in the short arm of chromosome 6 and composed of seven introns and eight exons. The HLA-G gene has a lower frequency polymorphism in the coding area and higher variability at the regulatory 5'- and 3'-untranslated regions linked to HLA-G microRNA regulation. HLA-G molecule is known to have an immunomodulatory and tolerogenic features role. In 199 Saudi individuals, we examined the association between plasma soluble HLA-G (sHLA-G) levels and eight polymorphic different sites, including 14 bp ins/del/+3003T-C/+3010C-G/+3027C-A/+3035C-T/+3142C-G/+3187A-G/+3196C-G single nucleotide polymorphisms (SNPs) in exon 8 in the HLA-G gene. Our results revealed higher frequency for rs17179101C (97%), rs1707T (92%) and rs9380142A (73%) alleles. Greater frequencies for the tested genotypes were observed in 3027C/C (rs17179101) (93%), 14 bp (rs1704) ins/del (92%), +3003T/T (rs1707) (85%) and +3035C/T (rs17179108) (79%) SNP genotypes. Moreover, we observed a significant association of sHLA-G with +3010G/C (rs1710) SNP. In conclusion, we showed a significant association between 3010G/C (rs1710) SNP and the sHLA-G level among our sample for Saudi populations. Our findings demonstrated that specific SNP within the HLA-G gene is linked to sHLA-G molecule secretion, suggesting sHLA-G levels may be regulated genetically. (© 2023 The Authors. International Journal of Immunogenetics published by John Wiley & Sons Ltd.)
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معلومات مُعتمدة:	IRF#019-055 King Fahad Medical City
فهرسة مساهمة:	Keywords: 3010G/C (rs1710) SNP; 3′UTR of HLA-G; HLA-G; HLA-G Haplotypes; HLA-G gene; sHLA-G
المشرفين على المادة:	0 (HLA-G Antigens) 0 (3' Untranslated Regions) 0 (Histocompatibility Antigens Class II)
تواريخ الأحداث:	Date Created: 20231213 Date Completed: 20240110 Latest Revision: 20240110
رمز التحديث:	20240110
DOI:	10.1111/iji.12648
PMID:	38087909
قاعدة البيانات:	MEDLINE

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تدمد:	1744-313X
DOI:	10.1111/iji.12648