دورية أكاديمية
Magnolol supplementation alleviates diquat-induced oxidative stress via PI3K-Akt in broiler chickens.
| العنوان: | Magnolol supplementation alleviates diquat-induced oxidative stress via PI3K-Akt in broiler chickens. |
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| المؤلفون: | Peng WS; College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.; Hunan Engineering Research Center of Poultry Production Safety, Changsha, China., Gao M; Bright Farming Co., Ltd., Shanghai, China., Yao XF; College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.; Hunan Engineering Research Center of Poultry Production Safety, Changsha, China., Tong YY; College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.; Hunan Engineering Research Center of Poultry Production Safety, Changsha, China., Zhang HH; College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.; Hunan Engineering Research Center of Poultry Production Safety, Changsha, China., He X; College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.; Hunan Engineering Research Center of Poultry Production Safety, Changsha, China. |
| المصدر: | Animal science journal = Nihon chikusan Gakkaiho [Anim Sci J] 2023 Jan-Dec; Vol. 94 (1), pp. e13891. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: Australia NLM ID: 100956805 Publication Model: Print Cited Medium: Internet ISSN: 1740-0929 (Electronic) Linking ISSN: 13443941 NLM ISO Abbreviation: Anim Sci J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Richmond, Vic. : Wiley Original Publication: Tokyo, Japan : Japanese Society of Zootechnical Science [1999- |
| مواضيع طبية MeSH: | Antioxidants*/metabolism , Chickens*/metabolism, Animals ; Male ; Diet/veterinary ; Dietary Supplements ; Diquat/adverse effects ; Oxidative Stress ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism |
| مستخلص: | This experiment was conducted to investigate the effects of magnolol on the oxidative parameters and jejunum injury induced by diquat in broiler chickens. This test adopts a 2 × 2 factors design, a total of 288 one-day-old male AA broiler chicks randomly allocated to four groups, consisting of six replicates of 12 birds each, which was then denoted as CON group, diquat (DIQ) group (16 mg/kg BW diquat was injected into birds at the age of 21 days), magnolol (MAG) group (basic bird diet supplemented with 300 mg/kg magnolol), and MAG + DIQ group. At 21 days of age, broilers in the DIQ group and the MAG + DIQ group were intraperitoneally injected with 16 mg/kg BW diquat. Results showed that diet supplementing with MAG could alleviate the decrease of ADG to a certain extent after exposure to DIQ. Addition of magnolol to the diet alleviated the decrease of ADG during injection, antioxidant enzymes, and gene expression and increased the markers of oxidative damage induced by diquat induction. Magnolol supplement reversed the increase of apoptotic cells in the diquat-induced chicken jejunum. RNA sequencing showed that PI3K-Akt, calcium, and NF-kappa B signaling pathways were the main enrichment pathways between the DIQ group and the MAG + DIQ group. Our findings revealed that magnolol may improve antioxidant enzyme activity and expression of related genes through the PI3K-Akt pathway to alleviate oxidative stress. (© 2023 Japanese Society of Animal Science.) |
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| معلومات مُعتمدة: | 31872378 National Natural Science Foundation of China; 2020TJ-Q02 Scientific and Technical Talents in Hunan Province |
| فهرسة مساهمة: | Keywords: PI3K-Akt pathway; broilers; diquat; jejunum damage; magnolol; oxidative stress |
| المشرفين على المادة: | 0 (Antioxidants) A9A615U4MP (Diquat) 001E35HGVF (magnolol) EC 2.7.1.- (Phosphatidylinositol 3-Kinases) EC 2.7.11.1 (Proto-Oncogene Proteins c-akt) |
| تواريخ الأحداث: | Date Created: 20231213 Date Completed: 20240108 Latest Revision: 20240108 |
| رمز التحديث: | 20240109 |
| DOI: | 10.1111/asj.13891 |
| PMID: | 38088251 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1740-0929 |
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| DOI: | 10.1111/asj.13891 |