دورية أكاديمية
أعرض في EDS

Rapid Gastric emptying in spontaneously hypertensive rats.

التفاصيل البيبلوغرافية
العنوان: Rapid Gastric emptying in spontaneously hypertensive rats.
المؤلفون: Salman UA; Department of Radiology, UT Health San Antonio., Schwartz JG; Department of Pathology, Methodist Hospital., McMahan AC; Department of Pathology, UT Health San Antonio., Michalek JE; Department of Population Health Sciences, UT Health San Antonio, San Antonio, Texas, USA., Phillips WT; Department of Radiology, UT Health San Antonio.
المصدر: Journal of hypertension [J Hypertens] 2024 Mar 01; Vol. 42 (3), pp. 572-578. Date of Electronic Publication: 2023 Dec 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: Netherlands NLM ID: 8306882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5598 (Electronic) Linking ISSN: 02636352 NLM ISO Abbreviation: J Hypertens Subsets: MEDLINE
أسماء مطبوعة: Publication: [Alphen aan den Rijn, the Netherlands] : Wolters Kluwer Health, Inc.
Original Publication: London ; New York : Gower Academic Pub., [1983-
مواضيع طبية MeSH: Gastric Emptying* , Hypertension*, Rats ; Animals ; Humans ; Infant ; Rats, Inbred SHR ; Rats, Inbred WKY ; Glucose ; Blood Pressure/physiology
مستخلص: Objective: To assess the rate of gastric emptying in spontaneously hypertensive rats (SHR) and to evaluate rapid gastric emptying as a possible predisposing factor for hypertension. Rapid gastric emptying of carbohydrates, known to elevate postprandial serum glucose, has been reported to occur in many insulin-resistant states, including hypertension. SHR exhibit insulin resistance similar to human hypertensive patients. No prior studies have assessed gastric emptying of an oral glucose solution in SHR as compared with control Wistar Kyoto rats (WKY).
Methods: Using scintigraphic imaging, gastric emptying of a physiologic, orally consumed glucose solution was assessed in 12 SHR and 12 control WKY at 5 weeks of age, prior to the development of hypertension, and at 12 weeks of age after hypertension was fully established.
Results: At 5 weeks, the gastric half-emptying time (GHET) was 67.8 ± 9.8 min for the SHR vs. 109.3 ± 18 ( P  = 0.042) minutes for the WKY controls. At 12 weeks, the GHET was 37.29 ± 10.3 min for the SHR vs. 138.53 ± 37.6 ( P  = 0.016) min for the WKY controls.
Conclusion: Gastric emptying was significantly more rapid in the SHR before and after the development of hypertension. Even though SHR are known to have increased sympathetic activity associated with their development of hypertension, this increased sympathetic activity does not inhibit gastric emptying. SHR are a promising animal model for investigating therapeutic agents for treating hypertension aimed at slowing the rate of gastric emptying.
(Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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المشرفين على المادة: IY9XDZ35W2 (Glucose)
تواريخ الأحداث: Date Created: 20231213 Date Completed: 20240201 Latest Revision: 20240201
رمز التحديث: 20240201
DOI: 10.1097/HJH.0000000000003640
PMID: 38088427
قاعدة البيانات: MEDLINE
الوصف
تدمد:1473-5598
DOI:10.1097/HJH.0000000000003640