دورية أكاديمية
Synaptic plasticity at the dentate gyrus granule cell to somatostatin-expressing interneuron synapses supports object location memory.
| العنوان: | Synaptic plasticity at the dentate gyrus granule cell to somatostatin-expressing interneuron synapses supports object location memory. |
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| المؤلفون: | Grigoryan G; Laboratory of Systems & Cellular Neuroscience, Institute for Physiology I, Medical Faculty, University of Freiburg, Freiburg 79104, Germany., Harada H; Molecular Physiology, Institute for Physiology II, Medical Faculty, University of Freiburg, Freiburg 79104, Germany., Knobloch-Bollmann HS; Laboratory of Systems & Cellular Neuroscience, Institute for Physiology I, Medical Faculty, University of Freiburg, Freiburg 79104, Germany., Kilias A; Laboratory of Systems & Cellular Neuroscience, Institute for Physiology I, Medical Faculty, University of Freiburg, Freiburg 79104, Germany., Kaufhold D; Laboratory of Systems & Cellular Neuroscience, Institute for Physiology I, Medical Faculty, University of Freiburg, Freiburg 79104, Germany., Kulik A; Molecular Physiology, Institute for Physiology II, Medical Faculty, University of Freiburg, Freiburg 79104, Germany., Eyre MD; Laboratory of Systems & Cellular Neuroscience, Institute for Physiology I, Medical Faculty, University of Freiburg, Freiburg 79104, Germany., Bartos M; Laboratory of Systems & Cellular Neuroscience, Institute for Physiology I, Medical Faculty, University of Freiburg, Freiburg 79104, Germany. |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Dec 19; Vol. 120 (51), pp. e2312752120. Date of Electronic Publication: 2023 Dec 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : National Academy of Sciences |
| مواضيع طبية MeSH: | Mossy Fibers, Hippocampal*/physiology , Neuronal Plasticity*/physiology, Mice ; Animals ; Interneurons/physiology ; Long-Term Potentiation/physiology ; Synapses/metabolism ; Somatostatin/metabolism ; Dentate Gyrus/metabolism ; Synaptic Transmission |
| مستخلص: | Somatostatin-expressing interneurons (SOMIs) in the mouse dentate gyrus (DG) receive feedforward excitation from granule cell (GC) mossy fiber (MF) synapses and provide feedback lateral inhibition onto GC dendrites to support environment representation in the DG network. Although this microcircuitry has been implicated in memory formation, little is known about activity-dependent plastic changes at MF-SOMI synapses and their influence on behavior. Here, we report that the metabotropic glutamate receptor 1α (mGluR1α) is required for the induction of associative long-term potentiation (LTP) at MF-SOMI synapses. Pharmacological block of mGluR1α, but not mGluR5, prevented synaptic weight changes. LTP at MF-SOMI synapses was postsynaptically induced, required increased intracellular Ca 2+ , involved G-protein-mediated and Ca 2+ -dependent (extracellular signal-regulated kinase) ERK1/2 pathways, and the activation of NMDA receptors. Specific knockdown of mGluR1α in DG-SOMIs by small hairpin RNA expression prevented MF-SOMI LTP, reduced SOMI recruitment, and impaired object location memory. Thus, postsynaptic mGluR1α-mediated MF-plasticity at SOMI input synapses critically supports DG-dependent mnemonic functions. Competing Interests: Competing interests statement:The authors declare no competing interest. |
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| معلومات مُعتمدة: | BA1582/12-1 Deutsche Forschungsgemeinschaft (DFG); FOR2143 Deutsche Forschungsgemeinschaft (DFG); DLR 01GQ1901 Bundesministerium für Bildung und Forschung (BMBF); 787450 ERC-AdG; BA 1582/19-1 Deutsche Forschungsgemeinschaft (DFG) |
| فهرسة مساهمة: | Keywords: dentate gyrus; interneuron; mGluR1α; object location memory; synaptic plasticity |
| المشرفين على المادة: | 51110-01-1 (Somatostatin) |
| تواريخ الأحداث: | Date Created: 20231213 Date Completed: 20231216 Latest Revision: 20231224 |
| رمز التحديث: | 20231224 |
| مُعرف محوري في PubMed: | PMC10742375 |
| DOI: | 10.1073/pnas.2312752120 |
| PMID: | 38091292 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1091-6490 |
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| DOI: | 10.1073/pnas.2312752120 |