Time-Sequential and Multi-Functional 3D Printed MgO 2 /PLGA Scaffold Developed as a Novel Biodegradable and Bioactive Bone Substitute for Challenging Postsurgical Osteosarcoma Treatment.

التفاصيل البيبلوغرافية
العنوان:	Time-Sequential and Multi-Functional 3D Printed MgO 2 /PLGA Scaffold Developed as a Novel Biodegradable and Bioactive Bone Substitute for Challenging Postsurgical Osteosarcoma Treatment.
المؤلفون:	Li C; Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.; University of Chinese Academy of Sciences, Beijing, 101408, China., Zhang W; Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.; University of Chinese Academy of Sciences, Beijing, 101408, China., Nie Y; Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.; University of Chinese Academy of Sciences, Beijing, 101408, China., Du X; Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.; University of Chinese Academy of Sciences, Beijing, 101408, China., Huang C; Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.; University of Chinese Academy of Sciences, Beijing, 101408, China., Li L; University of Chinese Academy of Sciences, Beijing, 101408, China., Long J; Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.; University of Chinese Academy of Sciences, Beijing, 101408, China., Wang X; Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.; University of Chinese Academy of Sciences, Beijing, 101408, China., Tong W; Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, 999077, China., Qin L; Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.; University of Chinese Academy of Sciences, Beijing, 101408, China.; Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, 999077, China., Lai Y; Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.; University of Chinese Academy of Sciences, Beijing, 101408, China.
المصدر:	Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2024 Aug; Vol. 36 (34), pp. e2308875. Date of Electronic Publication: 2023 Dec 24.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9885358 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4095 (Electronic) Linking ISSN: 09359648 NLM ISO Abbreviation: Adv Mater Subsets: MEDLINE
أسماء مطبوعة:	Publication: Sept. 3, 1997- : Weinheim : Wiley-VCH Original Publication: Deerfield Beach, FL : VCH Publishers, 1989-
مواضيع طبية MeSH:	Osteosarcoma/drug therapy , Osteosarcoma/pathology , Osteosarcoma/metabolism , Printing, Three-Dimensional , Tissue Scaffolds/chemistry , Magnesium Oxide/chemistry , Polylactic Acid-Polyglycolic Acid Copolymer/chemistry , Osteogenesis/drug effects , Bone Substitutes/chemistry , Bone Substitutes/pharmacology, Animals ; Humans ; Cell Line, Tumor ; Bone Neoplasms/drug therapy ; Bone Neoplasms/pathology ; Bone Neoplasms/metabolism ; Mice ; Hydrogen Peroxide/chemistry ; Hydrogen Peroxide/metabolism ; Nanocomposites/chemistry ; Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/drug effects ; Mesenchymal Stem Cells/metabolism
مستخلص:	Osteosarcoma (OS) is the most commonly occurring primary bone malignant tumor. The clinical postsurgical OS treatment faces big challenges for the staged therapeutic requirements of early anti-tumor, anti-bacterial, and long-lasting osteogenesis. Herein, multi-functional bioactive scaffolds with time-sequential functions of preventing tumor recurrence, inhibiting bacterial infection, and promoting bone defect repair are designed as a novel strategy. Nanocomposite scaffold magnesium peroxide (MgO 2 )/poly (lactide-co-glycolide) is prepared by low-temperature 3D printing for controllable releasing magnesium ions (Mg ²⁺ ) and reactive oxygen species in a time-sequential manner. The scaffold with 20 wt% MgO 2 (20MP) is verified with desired mechanical properties, as well as exhibits staged release behavior of bioactive elements with hydrogen peroxide (H 2 O 2 ) release for the first 3 weeks, and long-lasting Mg ²⁺ release for 12 weeks. The released H 2 O 2 initiates chemodynamic therapy to induce apoptosis and ferroptosis in tumor cells, along with activating the anticancer immune microenvironment by M1 polarization of macrophages. The released Mg ²⁺ subsequently enhances bone repair by activating the Wnt3a/GSK-3β/β-catenin signaling pathway to promote osteogenic differentiation of bone marrow mesenchymal stem cells and create osteopromotive immune microenvironment by M2 polarization of macrophages. In conclusion, the multi-functional 20MP scaffold demonstrates time-sequential therapeutic properties as an innovative strategy for OS-associated bone defect treatment. (© 2023 Wiley‐VCH GmbH.)
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معلومات مُعتمدة:	82022045 National Natural Science Foundation of China; 22007098 National Natural Science Foundation of China; U22A20162 National Natural Science Foundation of China; JCTD-2020-19 CAS Interdisciplinary Innovation Team; B2302050 Shenzhen Medical Research Funds; AoE/M-402/20 Areas of Excellence Scheme; MHP/030/20 Mainland-Hong Kong Joint Funding Scheme; 2023A1515011315 Basic and Applied Basic Research Foundation of Guangdong Province
فهرسة مساهمة:	Keywords: MgO2/poly (lactide‐co‐glycolide) scaffold; antibacterial and osteogenic activities; anti‐tumor; bone defects; osteosarcoma
المشرفين على المادة:	3A3U0GI71G (Magnesium Oxide) 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer) 0 (Bone Substitutes) BBX060AN9V (Hydrogen Peroxide) 0 (Biocompatible Materials)
تواريخ الأحداث:	Date Created: 20231213 Date Completed: 20240821 Latest Revision: 20240821
رمز التحديث:	20240822
DOI:	10.1002/adma.202308875
PMID:	38091500
قاعدة البيانات:	MEDLINE

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تدمد:	1521-4095
DOI:	10.1002/adma.202308875