دورية أكاديمية
Time-Sequential and Multi-Functional 3D Printed MgO 2 /PLGA Scaffold Developed as a Novel Biodegradable and Bioactive Bone Substitute for Challenging Postsurgical Osteosarcoma Treatment.
العنوان: | Time-Sequential and Multi-Functional 3D Printed MgO |
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المؤلفون: | Li C; Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.; University of Chinese Academy of Sciences, Beijing, 101408, China., Zhang W; Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.; University of Chinese Academy of Sciences, Beijing, 101408, China., Nie Y; Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.; University of Chinese Academy of Sciences, Beijing, 101408, China., Du X; Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.; University of Chinese Academy of Sciences, Beijing, 101408, China., Huang C; Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.; University of Chinese Academy of Sciences, Beijing, 101408, China., Li L; University of Chinese Academy of Sciences, Beijing, 101408, China., Long J; Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.; University of Chinese Academy of Sciences, Beijing, 101408, China., Wang X; Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.; University of Chinese Academy of Sciences, Beijing, 101408, China., Tong W; Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, 999077, China., Qin L; Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.; University of Chinese Academy of Sciences, Beijing, 101408, China.; Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, 999077, China., Lai Y; Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.; University of Chinese Academy of Sciences, Beijing, 101408, China. |
المصدر: | Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2024 Aug; Vol. 36 (34), pp. e2308875. Date of Electronic Publication: 2023 Dec 24. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9885358 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4095 (Electronic) Linking ISSN: 09359648 NLM ISO Abbreviation: Adv Mater Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Sept. 3, 1997- : Weinheim : Wiley-VCH Original Publication: Deerfield Beach, FL : VCH Publishers, 1989- |
مواضيع طبية MeSH: | Osteosarcoma*/drug therapy , Osteosarcoma*/pathology , Osteosarcoma*/metabolism , Printing, Three-Dimensional* , Tissue Scaffolds*/chemistry , Magnesium Oxide*/chemistry , Polylactic Acid-Polyglycolic Acid Copolymer*/chemistry , Osteogenesis*/drug effects , Bone Substitutes*/chemistry , Bone Substitutes*/pharmacology, Animals ; Humans ; Cell Line, Tumor ; Bone Neoplasms/drug therapy ; Bone Neoplasms/pathology ; Bone Neoplasms/metabolism ; Mice ; Hydrogen Peroxide/chemistry ; Hydrogen Peroxide/metabolism ; Nanocomposites/chemistry ; Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/drug effects ; Mesenchymal Stem Cells/metabolism |
مستخلص: | Osteosarcoma (OS) is the most commonly occurring primary bone malignant tumor. The clinical postsurgical OS treatment faces big challenges for the staged therapeutic requirements of early anti-tumor, anti-bacterial, and long-lasting osteogenesis. Herein, multi-functional bioactive scaffolds with time-sequential functions of preventing tumor recurrence, inhibiting bacterial infection, and promoting bone defect repair are designed as a novel strategy. Nanocomposite scaffold magnesium peroxide (MgO (© 2023 Wiley‐VCH GmbH.) |
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معلومات مُعتمدة: | 82022045 National Natural Science Foundation of China; 22007098 National Natural Science Foundation of China; U22A20162 National Natural Science Foundation of China; JCTD-2020-19 CAS Interdisciplinary Innovation Team; B2302050 Shenzhen Medical Research Funds; AoE/M-402/20 Areas of Excellence Scheme; MHP/030/20 Mainland-Hong Kong Joint Funding Scheme; 2023A1515011315 Basic and Applied Basic Research Foundation of Guangdong Province |
فهرسة مساهمة: | Keywords: MgO2/poly (lactide‐co‐glycolide) scaffold; antibacterial and osteogenic activities; anti‐tumor; bone defects; osteosarcoma |
المشرفين على المادة: | 3A3U0GI71G (Magnesium Oxide) 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer) 0 (Bone Substitutes) BBX060AN9V (Hydrogen Peroxide) 0 (Biocompatible Materials) |
تواريخ الأحداث: | Date Created: 20231213 Date Completed: 20240821 Latest Revision: 20240821 |
رمز التحديث: | 20240822 |
DOI: | 10.1002/adma.202308875 |
PMID: | 38091500 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1521-4095 |
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DOI: | 10.1002/adma.202308875 |