دورية أكاديمية
أعرض في EDS

Clinical and neuroimaging correlates in a pilot randomized trial of aerobic exercise for major depression.

التفاصيل البيبلوغرافية
العنوان: Clinical and neuroimaging correlates in a pilot randomized trial of aerobic exercise for major depression.
المؤلفون: Moreira-Neto A; Laboratory of Magnetic Resonance in Neuroradiology - LIM- 44, University of São Paulo Faculty of Medicine Clinics Hospital, São Paulo, Brazil; Exercise Neuroscience Research Group, University of São Paulo, São Paulo, Brazil., Neves LM; Laboratory of Neuromuscular Adaptations to Strength Training, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil; Bipolar Disorder Program (PROMAN), Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil; Post-Graduate Program in Health Sciences, Santo Amaro University, São Paulo, Brazil., Miliatto A; Exercise Neuroscience Research Group, University of São Paulo, São Paulo, Brazil., Juday V; Anhembi Morumbi University (UAM), São Paulo, Brazil., Marquesini R; Laboratory of Neuromuscular Adaptations to Strength Training, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil., Lafer B; Bipolar Disorder Program (PROMAN), Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil., Cardoso EF; Laboratory of Magnetic Resonance in Neuroradiology - LIM- 44, University of São Paulo Faculty of Medicine Clinics Hospital, São Paulo, Brazil., Ugrinowitsch C; Laboratory of Neuromuscular Adaptations to Strength Training, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil., Nucci MP; Laboratory of Magnetic Resonance in Neuroradiology - LIM- 44, University of São Paulo Faculty of Medicine Clinics Hospital, São Paulo, Brazil., Silva-Batista C; Exercise Neuroscience Research Group, University of São Paulo, São Paulo, Brazil; Department of Neurology, Oregon Health & Science University, Portland, OR, United States of America.
المصدر: Journal of affective disorders [J Affect Disord] 2024 Feb 15; Vol. 347, pp. 591-600. Date of Electronic Publication: 2023 Dec 12.
نوع المنشور: Randomized Controlled Trial; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: Depressive Disorder, Major*/diagnostic imaging , Depressive Disorder, Major*/therapy, Humans ; Depression ; Pilot Projects ; Exercise/physiology ; Neuroimaging
مستخلص: Background: Aerobic exercise (AE) combined with pharmacotherapy is known to reduce depressive symptoms; however, studies have not focused on long-term AE for volumetric changes of brain regions (amygdala, thalamus, and nucleus accumbens [NAcc]) linked to the control of affective responses and hopelessness in individuals with major depression (MD). In addition, AE with motor complexity (AEMC) would be more effective than AE in causing brain plasticity. We compared the effects of 24 weeks of AE and AEMC combined with pharmacotherapy on clinical and volumetric outcomes in individuals with MD.
Methods: Forty medicated individuals with MD were randomly assigned to nonexercising control (C), AE, and AEMC groups. The training groups exercised for 60 min, twice a week for 24 weeks. Clinical and volumetric outcomes were assessed before and after the 24 weeks. Effect size (ES) and confidence interval (CI) were calculated for within-group and between-groups changes.
Results: AE and AEMC reduced hopelessness (ES = -0.73 and ES = -0.62, respectively) and increased affective responses (ES = 1.24 and ES = 1.56, respectively). Only AE increased amygdala (ES = 0.27 left and ES = 0.34 right), thalamus (ES = 0.33 left and ES = 0.26 right) and left NAcc (ES = 0.54) volumes. AE was more effective than the C group in reducing hopelessness and causing brain plasticity. The changes in the right amygdala volume showed a strong trend in explaining 72 % of the changes in affective responses following AE (p = 0.06).
Limitation: Lack of posttraining follow-up and small sample size.
Conclusion: These preliminary data indicate that AE combined with pharmacotherapy can cause clinical improvement and brain plasticity in individuals with MD.
Competing Interests: Declaration of competing interest None.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Affective response; Hopelessness; Limbic system; Motor complexity; Subcortical volume
تواريخ الأحداث: Date Created: 20231213 Date Completed: 20240108 Latest Revision: 20240208
رمز التحديث: 20240208
DOI: 10.1016/j.jad.2023.12.025
PMID: 38092282
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-2517
DOI:10.1016/j.jad.2023.12.025