دورية أكاديمية
Macrophage-mediated downregulation of lncRNA Carmn in mouse abdominal aortic aneurysm.
العنوان: | Macrophage-mediated downregulation of lncRNA Carmn in mouse abdominal aortic aneurysm. |
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المؤلفون: | Yang H; Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States., Zhou T; Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States., Liu B; Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States. Electronic address: bliu24@wisc.edu. |
المصدر: | Vascular pharmacology [Vascul Pharmacol] 2024 Mar; Vol. 154, pp. 107264. Date of Electronic Publication: 2023 Dec 12. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 101130615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3649 (Electronic) Linking ISSN: 15371891 NLM ISO Abbreviation: Vascul Pharmacol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: New York, NY : Elsevier Science, c2002- |
مواضيع طبية MeSH: | RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , Aortic Aneurysm, Abdominal*/metabolism, Mice ; Animals ; Down-Regulation ; Muscle, Smooth, Vascular/metabolism ; Macrophages/metabolism ; Contractile Proteins/genetics ; Contractile Proteins/metabolism ; Myocytes, Smooth Muscle/metabolism ; Aorta, Abdominal/metabolism |
مستخلص: | The long noncoding RNA (lncRNA) CARMN (cardiac mesoderm enhancer associated noncoding RNA) is a highly conserved lncRNA that expresses primarily by smooth muscle cells (SMCs). Recent literature demonstrates that CARMN plays a critical role in the differentiation and maintaining of the contractile state of vascular SMCs. Because aortic SMCs show diminished contractile proteins in abdominal aortic aneurysms (AAAs), we hypothesize that the expression of CARMN is downregulated in the aortic wall affected by aneurysm. In this study, we analyzed publicly available single-cell or bulk RNA sequencing data comparing healthy and aneurysmal mouse aortic tissues. In both healthy and diseased aortas, Carmn expression was enriched in SMCs characterized by the high expression of SMC-specific contractile proteins including Myh11 and Acta2. Carmn expression levels varied among the sub-clusters of SMCs and consequently along the aortic tree. Comparing to the corresponding sham aorta, aortas from 3 distinct AAA models contained less Carmn. To validate the Carmn downregulation, we induced AAA using the Angiotensin II and CaCl Competing Interests: Declaration of Competing Interest The authors state that the research was carried out without any commercial or financial affiliations that could be perceived as a potential conflict of interest. (Copyright © 2023. Published by Elsevier Inc.) |
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معلومات مُعتمدة: | R01 HL149404 United States HL NHLBI NIH HHS; R01 HL158073 United States HL NHLBI NIH HHS |
فهرسة مساهمة: | Keywords: Abdominal aortic aneurysm; Long noncoding RNA; Vascular diseases |
المشرفين على المادة: | 0 (RNA, Long Noncoding) 0 (Contractile Proteins) |
تواريخ الأحداث: | Date Created: 20231214 Date Completed: 20240311 Latest Revision: 20240430 |
رمز التحديث: | 20240501 |
مُعرف محوري في PubMed: | PMC10939852 |
DOI: | 10.1016/j.vph.2023.107264 |
PMID: | 38097098 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1879-3649 |
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DOI: | 10.1016/j.vph.2023.107264 |