دورية أكاديمية
Early human lung immune cell development and its role in epithelial cell fate.
| العنوان: | Early human lung immune cell development and its role in epithelial cell fate. |
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| المؤلفون: | Barnes JL; UCL Respiratory, Division of Medicine, University College London, London, UK., Yoshida M; UCL Respiratory, Division of Medicine, University College London, London, UK.; Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan., He P; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK., Worlock KB; UCL Respiratory, Division of Medicine, University College London, London, UK., Lindeboom RGH; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Netherlands Cancer Institute, Amsterdam, Netherlands., Suo C; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Pett JP; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Wilbrey-Clark A; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Dann E; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Mamanova L; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Enhanc3D Genomics Ltd, Cambridge, UK., Richardson L; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Polanski K; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Pennycuick A; UCL Respiratory, Division of Medicine, University College London, London, UK., Allen-Hyttinen J; UCL Respiratory, Division of Medicine, University College London, London, UK., Herczeg IT; UCL Respiratory, Division of Medicine, University College London, London, UK., Arzili R; UCL Respiratory, Division of Medicine, University College London, London, UK., Hynds RE; Epithelial Cell Biology in ENT Research (EpiCENTR) Group, Developmental Biology and Cancer Department, Great Ormond Street UCL Institute of Child Health, University College London, London, UK.; CRUK Lung Cancer Centre Of Excellence, UCL Cancer Institute, University College London, London, UK., Teixeira VH; UCL Respiratory, Division of Medicine, University College London, London, UK., Haniffa M; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.; Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Lim K; Wellcome Trust/CRUK Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.; Department of Life Sciences, Korea University, Seoul, Republic of Korea., Sun D; Wellcome Trust/CRUK Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Rawlins EL; Wellcome Trust/CRUK Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Oliver AJ; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Lyons PA; Department of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK., Marioni JC; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK.; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK., Ruhrberg C; UCL Institute of Ophthalmology, University College London, London, UK., Tuong ZK; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; Ian Frazer Centre for Children's Immunotherapy Research, Child Health Research Centre, Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia., Clatworthy MR; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Reading JL; CRUK Lung Cancer Centre Of Excellence, UCL Cancer Institute, University College London, London, UK.; Tumour Immunodynamics and Interception Laboratory, Cancer Institute, University College London, London, UK., Janes SM; UCL Respiratory, Division of Medicine, University College London, London, UK.; CRUK Lung Cancer Centre Of Excellence, UCL Cancer Institute, University College London, London, UK.; University College London Hospitals NHS Foundation Trust, London, UK., Teichmann SA; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.; Department of Physics/Cavendish Laboratory, University of Cambridge, Cambridge, UK., Meyer KB; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Nikolić MZ; UCL Respiratory, Division of Medicine, University College London, London, UK.; University College London Hospitals NHS Foundation Trust, London, UK. |
| المصدر: | Science immunology [Sci Immunol] 2023 Dec 15; Vol. 8 (90), pp. eadf9988. Date of Electronic Publication: 2023 Dec 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : American Association for the Advancement of Science, [2016]- |
| مواضيع طبية MeSH: | Immunity, Innate* , Lung*, Humans ; Cell Differentiation ; Killer Cells, Natural ; Epithelial Cells |
| مستخلص: | Studies of human lung development have focused on epithelial and mesenchymal cell types and function, but much less is known about the developing lung immune cells, even though the airways are a major site of mucosal immunity after birth. An unanswered question is whether tissue-resident immune cells play a role in shaping the tissue as it develops in utero. Here, we profiled human embryonic and fetal lung immune cells using scRNA-seq, smFISH, and immunohistochemistry. At the embryonic stage, we observed an early wave of innate immune cells, including innate lymphoid cells, natural killer cells, myeloid cells, and lineage progenitors. By the canalicular stage, we detected naive T lymphocytes expressing high levels of cytotoxicity genes and the presence of mature B lymphocytes, including B-1 cells. Our analysis suggests that fetal lungs provide a niche for full B cell maturation. Given the presence and diversity of immune cells during development, we also investigated their possible effect on epithelial maturation. We found that IL-1β drives epithelial progenitor exit from self-renewal and differentiation to basal cells in vitro. In vivo, IL-1β-producing myeloid cells were found throughout the lung and adjacent to epithelial tips, suggesting that immune cells may direct human lung epithelial development. |
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| معلومات مُعتمدة: | 220268 United Kingdom WT_ Wellcome Trust; MR/W025051/1 United Kingdom MRC_ Medical Research Council; MR/S035907/1 United Kingdom MRC_ Medical Research Council; 206194 United Kingdom WT_ Wellcome Trust; MR/R006237/1 United Kingdom MRC_ Medical Research Council; EDDPJT-NOV22/100042 United Kingdom CRUK_ Cancer Research UK; MR/P009581/1 United Kingdom MRC_ Medical Research Council; United Kingdom WT_ Wellcome Trust; MR/W00111X/1 United Kingdom MRC_ Medical Research Council; MR/R015635/1 United Kingdom MRC_ Medical Research Council; MR/S035842/1 United Kingdom MRC_ Medical Research Council; RP-2017-08-ST2-002 United Kingdom DH_ Department of Health; MR/S005579/1 United Kingdom MRC_ Medical Research Council; NC/X001644/1 United Kingdom NC3RS_ National Centre for the Replacement, Refinement and Reduction of Animals in Research |
| تواريخ الأحداث: | Date Created: 20231215 Date Completed: 20231218 Latest Revision: 20240724 |
| رمز التحديث: | 20240725 |
| مُعرف محوري في PubMed: | PMC7615868 |
| DOI: | 10.1126/sciimmunol.adf9988 |
| PMID: | 38100545 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2470-9468 |
|---|---|
| DOI: | 10.1126/sciimmunol.adf9988 |